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3.6.1.39: thymidine-triphosphatase

This is an abbreviated version!
For detailed information about thymidine-triphosphatase, go to the full flat file.

Word Map on EC 3.6.1.39

Reaction

dTTP
+
H2O
=
dTDP
+
phosphate

Synonyms

desoxythymidine-5'-triphosphatase, dTTPase, dTTPase-dUTPase, gene 4 protein, Gp4, T7 DNA helicase, T7 helicase, thymidine triphosphate nucleotidohydrolase

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.39 thymidine-triphosphatase

Inhibitors

Inhibitors on EC 3.6.1.39 - thymidine-triphosphatase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AgCl
-
Ki: 4 mM
dCTP
-
competitive inhibitor with dTTP as substrate, Ki: 0.25 mM
diphosphate
-
with dTTP or dUDP as substrate
dTDP
-
with dTTP or dUTP as substrate
dUDP
-
with dTTP or dUTP as substrate
dUTP
-
with dTTP as substrate
HgCl2
-
Ki: 0.6 mM
NaVO4
-
Ki: 0.8 mM
para-hydroxy-mercuribenzoate
-
no inhibition in presence of 25 mM beta-mercaptoethanol
Tartrate
-
Ki: 1.5 mM
additional information
-
different purin- and pyrimidinnucleotide tested
-