3.6.1.28: thiamine-triphosphatase
This is an abbreviated version!
For detailed information about thiamine-triphosphatase, go to the full flat file.
Word Map on EC 3.6.1.28
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3.6.1.28
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adenylyl
-
electricus
-
electrophorus
-
phosphohydrolases
-
hydrophila
-
tdp
-
nitrosomonas
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diphosphatase
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triphosphorylated
- 3.6.1.28
-
adenylyl
- electricus
- electrophorus
-
phosphohydrolases
- hydrophila
- tdp
- nitrosomonas
- diphosphatase
-
triphosphorylated
Reaction
Synonyms
25 kDa thiamine triphosphatase, 25-kDa thiamine triphosphatase, phosphatase, thiamine tri-, thiamine triphosphatase, Thtpa, ThTPase, TTPase
ECTree
3.6.1.28 thiamine-triphosphataseAdvanced search results
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Substrates Products on EC 3.6.1.28 - thiamine-triphosphatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ADP + phosphate
-
the catalytic efficiency is about 4 orders of magnitude lower than for thiamine triphosphate
-
-
?
ATP + H2O
ADP + phosphate
-
no activity with enzyme from brain and liver
-
-
?
ATP + H2O
ADP + phosphate
-
4% of the activity with thiamine triphosphate
-
-
?
CTP + H2O
CDP + phosphate
-
at 13% of the activity with thiamine triphosphate
-
-
?
CTP + H2O
CDP + phosphate
-
18% of the activity with thiamine triphosphate with liver enzyme, no activity with brain enzyme
-
-
?
GTP + H2O
GDP + phosphate
-
at 13% of the activity with thiamine triphosphate
-
-
?
GTP + H2O
GDP + phosphate
-
14% of the activity with thiamine triphosphate with liver enzyme, no activity with brain enzyme
-
-
?
GTP + H2O
GDP + phosphate
-
at 4% of the activity with thiamine triphosphate
-
-
?
ITP + H2O
IDP + phosphate
-
18% of the activity with thiamine triphosphate with liver enzyme, no activity with brain enzyme
-
-
?
thiamine diphosphate + H2O
thiamine monophosphate + phosphate
-
28% of the activity with thiamine triphosphate with liver enzyme, 6% of the activity with thiamine triphosphate with brain enzyme
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
absolute specificity
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
thiamine triphosphate may play an important role in the regulation of Cl- permeability
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
absolute specificity
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
the enzyme is very specific for thiamine triphosphate, mechanism, overview, binding of Mg2+ induces only a minor local conformational change, whereas ThTP binding causes a more global conformational change, free mThTPase has an open cleft fold, the enzyme in the ternary complex adopts a tunnel fold, overview
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
210008, 210009, 210010, 210011, 210012, 210013, 210014, 210015, 210016, 210017, 210018, 656873, 668963
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
enzyme is involved in thiamine metabolism
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
the enzyme may play a general role in neuronal metabolism rather than a specific role in excitability. There is no apparent correlation between enzyme expression and selective vulnerability of certain brain regions to thiamine deficiency
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
thiamine triphosphate as Mg2+-thiamine triphosphate complex
-
-
?
UTP + H2O
UDP + phosphate
-
29% of the activitry with thiamine triphosphate with liver enzyme, no activity with brain enzyme
-
-
?
UTP + H2O
UDP + phosphate
-
at 2% of the activity with thiamine triphosphate
-
-
?
additional information
?
-
-
Thtpa is known to decrease the levels of the energy currency molecule, thiamine triphosphate
-
-
?
additional information
?
-
Thtpa is known to decrease the levels of the energy currency molecule, thiamine triphosphate
-
-
?
