3.6.1.28: thiamine-triphosphatase
This is an abbreviated version!
For detailed information about thiamine-triphosphatase, go to the full flat file.
Word Map on EC 3.6.1.28
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3.6.1.28
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adenylyl
-
electricus
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electrophorus
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phosphohydrolases
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hydrophila
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tdp
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nitrosomonas
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diphosphatase
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triphosphorylated
- 3.6.1.28
-
adenylyl
- electricus
- electrophorus
-
phosphohydrolases
- hydrophila
- tdp
- nitrosomonas
- diphosphatase
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triphosphorylated
Reaction
Synonyms
25 kDa thiamine triphosphatase, 25-kDa thiamine triphosphatase, phosphatase, thiamine tri-, thiamine triphosphatase, Thtpa, ThTPase, TTPase
ECTree
3.6.1.28 thiamine-triphosphataseAdvanced search results
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results (Inhibitors
Inhibitors on EC 3.6.1.28 - thiamine-triphosphatase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
([2-[3-(4-Amino-2-methyl-pyrimidin-5-ylmethyl)-4-methyl-thiazol-5-yl]-ethoxy]-phosphonomethyl-phosphinoylmethyl)-phosphonic acid
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1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-hydroxyethyl)-2-methylpyridinium
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soluble enzyme: 50% inhibition at 2 mM. Membrane-bound enzyme: no inhibition up to 5 mM
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid
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1.0 mM, 62% inhibition of membrane-associated enzyme
4-acetamide-4'-isothiocyanostilbene-2,2'-disulfonic acid
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1.0 mM, 36% inhibition of membrane-associated enzyme
SDS
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IC50: about 0.3% W/v. The inhibition is partially reversible, probably due to correct refolding of the denatured enzyme
ADP
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1 mM, strongly inhibits membrane-associated enzyme, soluble enzyme is unaffected
ATP
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soluble enzyme: no inhibition up to 2 mM, membrane-bound enzyme: 50% inhibition at 5 mM
ATP
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1 mM, strongly inhibits membrane-associated enzyme, soluble enzyme is unaffected
Ca2+
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soluble enzyme: 50% inhibition at 5 mM, membrane-bound enzyme: 20% inhibition at 5 mM
chlorpromazine
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microsomal and soluble enzyme; no inhibition in presence of Ca2+
NO3-
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inhibition at pH 6.0. At pH 7.6 slight but consistent activation at 50 mM NO3-, higher concentrations are inhibitory
thiamine diphosphate
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soluble enzyme, at levels of substrate 2 to 3 times Km, no inhibition of membrane-associated enzyme
Zn2+
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inhibits at micromolar concentrations at pH 8.0, IC50: about 0.015-0.02 mM. Activates at pH 6.0
