3.6.1.28: thiamine-triphosphatase

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For detailed information about thiamine-triphosphatase, go to the full flat file.

Reaction

Synonyms

25 kDa thiamine triphosphatase, 25-kDa thiamine triphosphatase, phosphatase, thiamine tri-, thiamine triphosphatase, Thtpa, ThTPase, TTPase

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.28 thiamine-triphosphatase

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Results	in table
7	Activating Compound
487	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
2	Crystallization (Commentary)
3	Disease/ Diagnostics
2	General Stability
2	IC50 Value
62	Inhibitors
10	kcat/KM [mM/s]
5	Ki Value [mM]
47	KM Value [mM]
30	Localization
44	Metals/Ions
30	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
42	Organism
3	Pathway
9	PDB ID
22	pH Optimum
4	pH Range
15	Protein Variants
8	Purification (Commentary)
2	Reaction
1	Reaction Type
42	Reference
87	Source Tissue
44	Specific Activity [micromol/min/mg]
3	Storage Stability
75	Substrates and Products (Substrate)
6	Subunits
25	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
6	Temperature Stability [°C]
14	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.6.1.28 - thiamine-triphosphatase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

complex with tripolyphosphate, to 2.3 A resolution and docking solution of substrate thiamine triphosphate. The thiazole ring of the thiamine forms a stacking interaction with Trp53, and the aminopyrimidine ring lies in a pocket defined by His76, Pro191 and Ile195. The triphosphate moiety occupies a similar position as in the enzyme-tripolyphosphate complex, with interactions involving the side chains of Lys11, Arg55, Arg57, Lys65, Arg125 and Lys193

Homo sapiens

Q9BU02

733393

hanging drop vapor diffusion method, using 27% (w/v) PEG 3350, 0.1 M Tris (pH 9.0), 0.2 M MgCl2

Mus musculus

Q8JZL3

751047