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3.6.1.27: undecaprenyl-diphosphate phosphatase

This is an abbreviated version!
For detailed information about undecaprenyl-diphosphate phosphatase, go to the full flat file.

Word Map on EC 3.6.1.27

Reaction

ditrans,octacis-undecaprenyl diphosphate
+
H2O
=
ditrans,octacis-undecaprenyl phosphate
 +
phosphate

Synonyms

bacA, BcrC, C55-isoprenyl diphosphatase, C55-isoprenyl pyrophosphatase, C55-PP phosphatase, C55-PP pyrophosphatase, Dolicholpyrophosphatase, HP0851, HupA, isoprenyl pyrophosphatase, More, PbrB, PgpB, SMU.244, Und-pp phosphatase, undecaprenyl diphosphate phosphatase, undecaprenyl pyrophosphatase, undecaprenyl pyrophosphate phosphatase, undecaprenyl-pyrophosphate phosphatase, UPP phosphatase, Upp-P, UPP-Pase, UppP, YbjG, YeiU

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.27 undecaprenyl-diphosphate phosphatase

Engineering

Engineering on EC 3.6.1.27 - undecaprenyl-diphosphate phosphatase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D111A
mutation in membrane-water interface, 100% residual activity
D150A
mutation in membrane-water interface, 64% residual activity
D43A
mutation in aequous interface, 73% residual activity
E17A
mutation within the consensus regions, 26% residiual activity
E17A/E21A
mutation within the consensus regions, mutant is completely inactive
E194A
mutation in aequous interface, 31% residual activity
E41A
mutation in aequous interface, 85% residual activity
E49A
mutation in membrane-water interface, 36% residual activity
Q164A
-
the mutant shows 24.3% of wild type activity
Q53A
mutation in membrane-water interface, 14% residual activity
R174A
R189A
R261A
completely inactive
S173A
S175A
S196A
-
the mutant shows 36.8% of wild type activity
S26A
-
the mutant shows 15% of wild type activity
T178A
mutation within the consensus regions, mutant is completely inactive
G163R
the mutation leads to no protein expression at all
G168A
the mutation leads to no protein expression at all
S167A
the mutant shows 34% of wild type activity
S22A
the mutant shows less than 1.3% of wild type activity
S23A
the mutant shows 65% of wild type activity
additional information
-
construction of chromosomal gene deletions mutants, double and triple deletion mutants in the genes uppP and ybjG, and uppP, ybjG and yeiU, respectively, are supersensitive to the Und-P de novo biosynthesis inhibitor fosmidomycin, while single or combined deletions including pgpB have no effect on fosmidomycin supersensitivity, overview