3.6.1.25: triphosphatase

This is an abbreviated version!
For detailed information about triphosphatase, go to the full flat file.

Word Map on EC 3.6.1.25

3.6.1.25

atpase

na+

ouabain

k+-adenosine

ca2+-adenosine

cardiac

sarcoplasmic

na+,k+-adenosine

k+-atpase

ca2+-atpase

myosin

parietal

guanylyltransferase

na+,k+-atpase

contractile

5'-nucleotidase

tripolyphosphate

ouabain-sensitive

omeprazole

ecto-adenosine

inotropic

antisecretory

3.6.1.3

digoxin

diphosphatase

phospholamban

ecto-atpase

nak-atpase

lansoprazole

Reaction

Synonyms

inorganic triphosphatase, triphosphate tunnel metalloenzyme, tripolyphosphatase, TTM

ECTree

3 Hydrolases

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.25 triphosphatase

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Results	in table
283	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
1	Crystallization (Commentary)
3	IC50 Value
4	Inhibitors
11	kcat/KM [mM/s]
17	KM Value [mM]
3	Localization
3	Metals/Ions
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
6	Organism
8	PDB ID
1	pH Optimum
5	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
6	Reference
1	Source Tissue
12	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
3	Subunits
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
11	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.6.1.25 - triphosphatase

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ATP + H2O

Nitrosomonas europaea

low affinity

719965

triphosphate + H2O

diphosphate + phosphate

7 entries

tripolyphosphate + H2O

diphosphate + phosphate

Nitrosomonas europaea

very good substrate with Mg2+ as activator. The enzyme has a strong preference for linear tripolyphosphate compared with cyclic trimetaphosphate and to the linear tetraphosphate

719965

additional information

Nitrosomonas europaea

the enzyme has low affinity for CTP, ATP or thiamine triphosphate. Nucleoside triphosphatase activity is negligible in the presence of 5 mM Mg2+, but a small activity is observed in the presence of 1 mM Mn2+, in particular with GTP. Guanosine 5-tetraphosphate and long chain polyphosphate (containing about 65 phosphate residues) are not hydrolyzed. The enzyme has no adenylyl cyclase activity

719965