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3.6.1.23: dUTP diphosphatase

This is an abbreviated version!
For detailed information about dUTP diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.23

Reaction

dUTP
+
H2O
=
dUMP
 +
diphosphate

Synonyms

DCD-DUT, dCTP deaminase-dUTPase, dCTP deaminase:dUTPase, deoxyuridine 5'-triphosphate, deoxyuridine 5'-triphosphate nucleotide hydrolase, deoxyuridine 5'-triphosphate nucleotidohydrolase, deoxyuridine 5'-triphosphate pyrophosphatase, deoxyuridine 50-triphosphate nucleotidohydrolase, deoxyuridine 5’-triphosphate nucleotidohydrolase, deoxyuridine nucleotidohydrolase, deoxyuridine triphosphatase, deoxyuridine triphosphate nucleotidohydrolase, deoxyuridine triphosphate pyrophosphatase, deoxyuridine-5'-triphosphate nucleotidohydrolase, deoxyuridine-triphosphate pyrophosphatase, desoxyuridine 5'-triphosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, desoxyuridine-triphosphatase, DURP, DUT, DUT-N, DUT1, dUTP nucleotidohydrolase, dUTP pyrophosphatase, dUTPae, dUTPase, dUTPase-dUDPase, dUTPase-related protein, E165R, More, ORF 54, ORF8, P18, PIP4, Pr95, STSV2_30, Tb927.7.5160, U45, YncF, YosS

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.23 dUTP diphosphatase

KI Value

KI Value on EC 3.6.1.23 - dUTP diphosphatase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0013
1-(2-amido-4-trityloxybutyl)uracil
pH and temperature not specified in the publication
0.0027
1-(2-dimethylamido-4-trityloxybutyl)uracil
pH and temperature not specified in the publication
0.0021
1-(2-morpholinamido-4-trityloxybutyl)uracil
pH and temperature not specified in the publication
0.073
1-(3-tert-butyldimethylsilyloxypropyl)uracil
0.0016 - 0.025
1-(3-triphenylsilyloxypropyl)uracil
0.0002 - 0.0014
1-(3-tritylaminopropyl)uracil
0.087 - 0.313
1-(3-trityloxypropyl)uracil
0.0038 - 1
1-(5-triphenylsilyloxypentyl)uracil
0.0043 - 1
1-(5-tritylaminopentyl)uracil
0.002 - 1
1-(5-trityloxypentyl)uracil
0.0033
1-[(1Z,8E)-5-([[(E)-(3,4-dihydroxy-5-methoxybenzylidene)amino]oxy]methyl)-1-(3,4-dihydroxy-5-methoxyphenyl)-3,7-dioxa-2,8-diazadeca-1,8-dien-10-yl]pyrimidine-2,4(1H,3H)-dione
in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C
0.00009 - 0.006
1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.00021 - 0.017
1-[(2R,5S)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
0.00039 - 0.0203
1-[(2R,5S)-5-[(trityloxy)methyl]-2,5-dihydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
0.0006 - 1
1-[(E)-4-trityloxy-2-butenyl]uracil
0.0012 - 0.0052
1-[(Z)-4-trityloxy-2-butenyl]uracil
0.005
1-[2-(acetamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
pH and temperature not specified in the publication
0.0055
1-[2-(acetamido)-4-(triphenylmethyl)aminobutyl]uracil
pH and temperature not specified in the publication
0.023 - 1
1-[2-(azidomethyl)-4-(trityloxy)butyl]uracil
0.0065
1-[2-(carbobenzoxymethyl)-4-(triphenylmethyl)aminobutyl]uracil
pH and temperature not specified in the publication
0.0005
1-[2-(carboethoxyethylamido)-4-trityloxybutyl]uracil
pH and temperature not specified in the publication
0.0016
1-[2-(carboxy)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
pH and temperature not specified in the publication
0.0072
1-[2-(carboxy)-4-(triphenylmethyl)aminobutyl]uracil
pH and temperature not specified in the publication
0.0002
1-[2-(carboxyethylamido)-4-trityloxybutyl]uracil
pH and temperature not specified in the publication
0.02
1-[2-(diethylamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
pH and temperature not specified in the publication
0.0057
1-[2-(ethylamido)-4-(tert-butyldiphenylsilyloxy) butyl]uracil
pH and temperature not specified in the publication
0.0004
1-[2-(hydroxyethylamido)-4-trityloxybutyl]uracil
pH and temperature not specified in the publication
0.0022 - 0.26
1-[2-(hydroxymethyl)-4-(trityloxy)butyl]uracil
0.0014
1-[2-(methoxyethylamido)-4-trityloxybutyl]uracil
pH and temperature not specified in the publication
0.0036
1-[2-(methylamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
pH and temperature not specified in the publication
0.0078
1-[2-(N,N-dimethylaminoethylamido)-4-trityloxybutyl]uracil
pH and temperature not specified in the publication
0.098
1-[2-(N-benzyloxycarbonylpiperazinamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
pH and temperature not specified in the publication
0.0056
1-[2-(N-methylpiperazine)amido-4-trityloxybutyl]uracil
pH and temperature not specified in the publication
0.01
1-[2-(tert-butyldiphenylsilyloxyethylamido)-4-trityloxybutyl]uracil
Ki above 0.01 mM, pH and temperature not specified in the publication
0.0007 - 0.017
1-[2-(trityloxy)ethoxymethyl]uracil
0.0007
1-[3-(benzhydrylaminocarbonyl)propyl]uracil
-
pH 8.0, temperature not specified in the publication
0.00004 - 0.028
1-[3-(tritylamino)propyl]pyrimidine-2,4(1H,3H)-dione
0.0002
1-[3-(tritylaminocarbonyl)propyl]uracil
-
pH 8.0, temperature not specified in the publication
0.0025 - 1
1-[4-(tert-butoxycarbonylamino)-3-(trityloxymethyl)butyl]uracil
0.0013 - 0.074
1-[4-acetoxy-3-(tritylaminomethyl)butyl]uracil
0.0009 - 0.021
1-[4-hydroxy-2-(trityloxymethyl)butyl]uracil
0.00024 - 0.0057
1-[4-hydroxy-3-(tritylaminomethyl)butyl]uracil
0.00004 - 0.029
1-[4-hydroxy-3-[(tritylamino)methyl]butyl]pyrimidine-2,4(1H,3H)-dione
0.00015 - 0.035
1-[6-(tritylamino)hexyl]pyrimidine-2,4(1H,3H)-dione
0.0373
1-[N-(2-triphenylmethylaminoethyl)-acetamide]uracil
-
-
0.0231
1-[N-(3-triphenylmethylaminopropyl)-acetamide]uracil
-
-
1
1-[N-(4-triphenylmethylaminobutyl)-acetamide]uracil
-
above
1
1-[N-(triphenylmethyl) diaminodi(n-propyl) acetamide]uracil
-
above
1
1-[N-(triphenylmethylaminoethyl)-N-(aminoethyl) acetamide]uracil
-
above
1
1-[N-hydroxyethyl-N-(triphenylmethylamino) ethyl-acetamide]uracil
-
above
0.0007 - 0.017
1-[[2-(trityloxy)ethoxy]methyl]pyrimidine-2,4(1H,3H)-dione
0.0125
2',3',5'-trideoxy-3'-fluoro-5'-(tritylamino)uridine
-
pH 5.7-6.2, recombinant enzyme
0.099 - 1
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
0.0048 - 0.406
2',3'-dideoxy-3'-fluoro-5'-O-trityluridine
0.00011 - 0.02
2',5'-dideoxy-5'-(tritylamino)uridine
0.026 - 1
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
0.0028
2'-deoxy-5'-O-(triphenylsilyl)uridine
-
pH 5.7-6.2, recombinant enzyme
0.0018
2'-deoxy-5'-O-trityluridine
-
pH 5.7-6.2, recombinant enzyme
0.2271
2'-deoxy-5'-O-[tris(1-methylethoxy)silyl]uridine
-
pH 5.7-6.2, recombinant enzyme
0.908
2'-deoxy-5'-triphenylmethanyluracil
-
pH 8.0, 25°C
0.135
2'-deoxyuracil 5'-diphenyl phosphate
-
pH 8.0, 25°C
0.018
2'-deoxyuridine 5'-(alpha,beta-imido)triphosphate
in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C
0.0093
3'-azido-2',3'-dideoxy-UTP
-
0.02 mM 3'-azido-2',3'-dideoxy-UTP in 0.05 mM bicine, with 5 mM MgCl2, pH and temperature not specified in the publication
0.067 - 1
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
0.088 - 1
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
0.156
3-[5-(trityloxy)tetrahydrofuran-2-yl]pyridine-2,6(1H,3H)-dione
-
pH 8.0, 25°C
0.805
5'-(2,2-dimethyl-1,1-diphenylpropan-1-yl)-2'-deoxyuracil
-
pH 8.0, 25°C
0.807
5'-(2,2-dimethyl-1,1-diphenylpropan-1-yl)-3'-methyl-2',3'-dideoxyuracil
-
pH 8.0, 25°C
0.298 - 0.547
5'-adamantoyl-3'-methyl-2',3'-dideoxyuracil
0.35
5'-hexadecanoyl-3'-methyl-2',3'-dideoxyuracil
-
pH 8.0, 25°C
0.058 - 0.433
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
2.5
5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine
-
25°C
0.082 - 1
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
0.0013 - 1
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
0.975 - 1
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
0.0028 - 1
5'-O-triphenylsilyl-2'-deoxyuridine
0.189 - 1
5'-pentanoylamino-2',5'-dideoxyuridine
0.089 - 1
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
0.0002 - 0.304
5'-tritylamino-2',5'-dideoxyuridine
0.012 - 1
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
0.00024
alpha,beta-imido-dUDP
-
25°C
0.0039
alpha,beta-imido-dUTP
pH 7.5, 25°C, wild-type enzyme
0.0009
alpha-beta-imido-dUTP
-
pH 8, 25°C
0.5
Cu2+
-
-
0.0114 - 0.099
dUMP
0.115 - 0.121
dUTP
0.092
dUTP-Co2+
-
pH 7.0, 25°C, recombinant enzyme
0.0955
dUTP-Mg2+
-
pH 7.0, 25°C, recombinant enzyme
0.0718
dUTP-Mn2+
-
pH 7.0, 25°C, recombinant enzyme
0.000021
N-[(1R)-1-[3-(cyclopropylmethoxy)-4-fluorophenyl]ethyl]-3-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]propane-1-sulfonamide
in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C
1
N-[3-(tert-butyl diphenyl silanyloxy)-propyl]-2-uracil acetamide
-
above
1
N-[4-(tert-butyl diphenyl silanyloxy)-butyl]-2-uracil acetamide
-
above
0.0000067
staphylococcal repressor protein StlSaPIBov1
-
at pH 7.5 and 20°C
-
additional information
2'-deoxy-5'-phenylmethylaminouracil