3.6.1.23: dUTP diphosphatase

This is an abbreviated version!
For detailed information about dUTP diphosphatase, go to the full flat file.

Reaction

Synonyms

DCD-DUT, dCTP deaminase-dUTPase, dCTP deaminase:dUTPase, deoxyuridine 5'-triphosphate, deoxyuridine 5'-triphosphate nucleotide hydrolase, deoxyuridine 5'-triphosphate nucleotidohydrolase, deoxyuridine 5'-triphosphate pyrophosphatase, deoxyuridine 50-triphosphate nucleotidohydrolase, deoxyuridine 5�-triphosphate nucleotidohydrolase, deoxyuridine nucleotidohydrolase, deoxyuridine triphosphatase, deoxyuridine triphosphate nucleotidohydrolase, deoxyuridine triphosphate pyrophosphatase, deoxyuridine-5'-triphosphate nucleotidohydrolase, deoxyuridine-triphosphate pyrophosphatase, desoxyuridine 5'-triphosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, desoxyuridine-triphosphatase, DURP, DUT, DUT-N, DUT1, dUTP nucleotidohydrolase, dUTP pyrophosphatase, dUTPae, dUTPase, dUTPase-dUDPase, dUTPase-related protein, E165R, More, ORF 54, ORF8, P18, PIP4, Pr95, STSV2_30, Tb927.7.5160, U45, YncF, YosS

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.23 dUTP diphosphatase

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Results	in table
2	Activating Compound
33833	AA Sequence
32	Application
1	CAS Registry Number
73	Cloned(Commentary)
44	Crystallization (Commentary)
670	Disease/ Diagnostics
2	Expression
22	General Information
2	General Stability
88	IC50 Value
352	Inhibitors
62	kcat/KM [mM/s]
173	Ki Value [mM]
139	KM Value [mM]
26	Localization
89	Metals/Ions
65	Molecular Weight [Da]
135	Natural Substrates/ Products (Substrates)
487	Organism
10	Pathway
409	PDB ID
23	pH Optimum
12	pH Range
1	pH Stability
5	pI Value
1	Posttranslational Modification
99	Protein Variants
71	Purification (Commentary)
19	Reaction
1	Reaction Type
210	Reference
50	Source Tissue
20	Specific Activity [micromol/min/mg]
8	Storage Stability
329	Substrates and Products (Substrate)
92	Subunits
261	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
5	Temperature Range [°C]
19	Temperature Stability [°C]
95	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.6.1.23 - dUTP diphosphatase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000026

(E)-3-(2,2-difluoroethoxy)-N-(7-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methylhept-5-en-2-yl)benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.000033

(E)-3-(cyclopentyloxy)-N-(7-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methylhept-5-en-2-yl)benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.000028

(E)-3-(cyclopropylmethoxy)-N-(7-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methylhept-5-en-2-yl)benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.00034

(E)-N-(7-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methylhept-5-en-2-yl)-3-methoxybenzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.0016

(E)-N-(7-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methylhept-5-en-2-yl)benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.01

(R)-1-(4-(2-(hydroxydiphenylmethyl)-pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.00041

(R)-N-(1-(3-(2,2-difluoroethoxy)phenyl)ethyl)-4-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.00043

(R)-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-4-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.00082

(R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-4-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.000082

(R,E)-N-(1-(3-(2,2-difluoroethoxy)phenyl)ethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pent-3-ene-1-sulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.000041

(R,E)-N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pent-3-ene-1-sulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.000039

(R,E)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pent-3-ene-1-sulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.001

1-(3-[[(2S)-2-[hydroxy[bis(2-methoxyphenyl)]methyl]pyrrolidin-1-yl]sulfonyl]propyl)pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

IC50 above 0.001 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.001

1-(3-[[(2S)-2-[hydroxy[bis(3-methoxyphenyl)]methyl]pyrrolidin-1-yl]sulfonyl]propyl)pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

IC50 above 0.001 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.00058

1-(4-[(2S)-2-[bis(3-chlorophenyl)(hydroxy)methyl]pyrrolidin-1-yl]-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.00035

1-(4-[(2S)-2-[bis(3-fluorophenyl)(hydroxy)methyl]pyrrolidin-1-yl]-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.001

1-(4-[(2S)-2-[bis(4-chlorophenyl)(hydroxy)methyl]pyrrolidin-1-yl]-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

IC50 above 0.001 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.0006

1-(4-[(2S)-2-[bis(4-fluorophenyl)(hydroxy)methyl]pyrrolidin-1-yl]-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.0073 - 0.03

1-[3-(4-benzylpiperidin-1-yl)-3-oxopropyl]pyrimidine-2,4(1H,3H)-dione

2 entries

0.0094

1-[3-([(2R)-2-[hydroxy(diphenyl)methyl]pyrrolidin-1-yl]sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.00028

1-[3-([(2S)-2-[bis(3-fluorophenyl)(hydroxy)methyl]pyrrolidin-1-yl]sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.00031

1-[3-([(2S)-2-[bis(4-fluorophenyl)(hydroxy)methyl]pyrrolidin-1-yl]sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.001

1-[3-[(2S)-2-(diphenylmethyl)pyrrolidin-1-yl]-3-oxopropyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

IC50 above 0.001 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.00015

1-[4-[(2S)-2-(diphenylmethyl)pyrrolidin-1-yl]-4-oxobutyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.001

1-[4-[(2S)-2-[bis[2-(benzyloxy)phenyl](hydroxy)methyl]pyrrolidin-1-yl]-4-oxobutyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

IC50 above 0.001 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.001

1-[4-[(2S)-2-[bis[3-(benzyloxy)phenyl](hydroxy)methyl]pyrrolidin-1-yl]-4-oxobutyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

IC50 above 0.001 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.001

1-[4-[(2S)-2-[bis[4-(benzyloxy)phenyl](hydroxy)methyl]pyrrolidin-1-yl]-4-oxobutyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

IC50 above 0.001 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.00023

1-[4-[(2S)-2-[hydroxy[di(thiophen-3-yl)]methyl]pyrrolidin-1-yl]-4-oxobutyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.0042

1-[N-(2-triphenylmethylaminoethyl)-acetamide]uracil

Plasmodium falciparum

-

-

697745

0.0025

1-[N-(3-triphenylmethylaminopropyl)-acetamide]uracil

Plasmodium falciparum

-

-

697745

0.0029

1-[N-(4-triphenylmethylaminobutyl)-acetamide]uracil

Plasmodium falciparum

-

above

697745

0.0039

1-[N-(triphenylmethyl) diaminodi(n-propyl) acetamide]uracil

Plasmodium falciparum

-

above

697745

0.0045

1-[N-(triphenylmethylaminoethyl)-N-(aminoethyl) acetamide]uracil

Plasmodium falciparum

-

above

697745

0.083

1-[N-hydroxyethyl-N-(triphenylmethylamino) ethyl-acetamide]uracil

Plasmodium falciparum

-

above

697745

0.3

1-[[2-(trityloxy)ethoxy]methyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

IC50 above 0.3 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.0053

2',3',5'-trideoxy-3'-fluoro-5'-(tritylamino)uridine

Plasmodium falciparum

-

activity against the parasites with IC50: 0.0053 mM

670909

0.002

2',3'-dideoxy-3'-fluoro-5'-O-trityluridine

Plasmodium falciparum

-

activity against the parasites with IC50: 0.0020 mM, binding structure involving Tyr112, Ile117, Ile108, and Asn103, overview

670909

0.0045

2',5'-dideoxy-5'-(tritylamino)uridine

Plasmodium falciparum

-

activity against the parasites with IC50: 0.0045 mM

670909

0.0011

2'-deoxy-5'-O-(triphenylsilyl)uridine

Plasmodium falciparum

-

activity against the parasites with IC50: 0.0011 mM

670909

0.006

2'-deoxy-5'-O-trityluridine

Plasmodium falciparum

-

activity against the parasites with IC50: 0.006 mM

670909

0.013

2'-deoxy-5'-O-[tris(1-methylethoxy)silyl]uridine

Plasmodium falciparum

-

activity against the parasites with IC50: 0.013 mM

670909

0.015

2'-deoxyuridine 5'-(alpha,beta-imido)triphosphate

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.000073

3-(2,2-difluoroethoxy)-N-(2-(4-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)propan-2-yl)-benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.03

3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2,4,4-trimethylpentan-2-yl)propanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-methylbutan-2-yl)propanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-phenylethyl)propanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.022

3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(3-ethylhexan-3-yl)propanamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(3-phenylpropyl)propanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(diphenylmethyl)propanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.000031

3-(cyclopentyloxy)-N-(2-(4-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)propan-2-yl)-benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.000073

3-(cyclopropylmethoxy)-N-(2-(4-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)propan-2-yl)-benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.000035

3-(cyclopropylmethoxy)-N-[5-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]-2-methylpentan-2-yl]benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.0025

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(1-hydroxy-2-methyl-1,1-diphenylpropan-2-yl)butanamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(1-hydroxy-2-methylpropan-2-yl)butanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.0013

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2,2-diphenylethyl)-N-methylbutanamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.016

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2,2-diphenylethyl)butanamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2,4,4-trimethylpentan-2-yl)butanamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.0011

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-hydroxy-2,2-diphenylethyl)-N-methylbutanamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-methyl-1-phenylpropan-2-yl)butanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.021

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-methyl-4-phenylbutan-2-yl)butanamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-phenylpropan-2-yl)butanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(3-ethylpentan-3-yl)butanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(diphenylmethyl)butanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-phenylbutanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-methyl-1-(naphthalen-2-yl)propan-2-yl]butanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

N,N-dibenzyl-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.00127

N-(2-(4-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-phenyl)propan-2-yl)-3-methoxybenzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.0018

N-(2-(4-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-phenyl)propan-2-yl)benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.03

N-benzyl-4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.00004

N-[(1R)-1-[3-(cyclopropylmethoxy)phenyl]ethyl]-3-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]propane-1-sulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.074

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-D-alanyl-L-tyrosine

Trypanosoma cruzi

-

-

685562

0.084

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-aspartic acid

Trypanosoma cruzi

-

-

685562

0.081

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-glutamic acid

Trypanosoma cruzi

-

-

685562

0.081

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-glutamine

Trypanosoma cruzi

-

-

685562

0.081

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-lysine

Trypanosoma cruzi

-

-

685562

0.087

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanyl-L-threonine

Trypanosoma cruzi

-

-

685562

0.1

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]-L-alanylglycine

Trypanosoma cruzi

-

-

685562

0.084

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycyl-L-lysine

Trypanosoma cruzi

-

-

685562

0.091

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycyl-L-threonine

Trypanosoma cruzi

-

-

685562

0.076

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycyl-L-tyrosine

Trypanosoma cruzi

-

-

685562

0.132

N-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]glycylglycine

Trypanosoma cruzi

-

-

685562

0.00034

N-[2-[3-(cyclopropylmethoxy)phenyl]propan-2-yl]-3-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]propane-1-sulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.0046

N-[3-(tert-butyl diphenyl silanyloxy)-propyl]-2-uracil acetamide

Plasmodium falciparum

-

above

697745

0.0037

N-[4-(tert-butyl diphenyl silanyloxy)-butyl]-2-uracil acetamide

Plasmodium falciparum

-

above

697745

0.0039

N-[5-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]-2-methylpentan-2-yl]benzenesulfonamide

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720201

0.00003

Stl repressor protein from Staphylococcus aureus

Drosophila melanogaster

-

at pH 7.5 and 20°C

756733

-

additional information

additional information

Trypanosoma cruzi

-

IC50 values of the inhibitor cytotoxicity assay on rat LC6 cells, overview

685562

-

0.0073

1-[3-(4-benzylpiperidin-1-yl)-3-oxopropyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198

0.03

1-[3-(4-benzylpiperidin-1-yl)-3-oxopropyl]pyrimidine-2,4(1H,3H)-dione

Homo sapiens

P33316

IC50 above 0.03 mM, in 0.2 M Tris buffer (pH 7.4), 16 mM MgCl2, at 37°C

720198