3.6.1.13: ADP-ribose diphosphatase

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For detailed information about ADP-ribose diphosphatase, go to the full flat file.

Reaction

Synonyms

adenosine 5'-diphosphosugar pyrophosphatase, adenosine diphosphoribose pyrophosphatase, ADP-ribose diphosphatase, ADP-ribose hydrolase, ADP-ribose phosphohydrolase, ADP-ribose pyrophosphatase, ADP-ribose pyrophosphatase Sll1054, ADP-ribose pyrophosphatase Slr0920, ADP-ribose pyrophosphatase Slr1134, ADP-ribose pyrophosphatase-I, ADP-ribose/CDP-alcohol diphosphatase, ADP-ribose/NADH pyrophosphohydrolase, ADPR pyrophosphatase, ADPR-PPase, ADPRase, ADPRase-I, ADPRibase, ADPRibase-Mn, ADPribose pyrophosphatase, Adprm, AT4G12720, AtNUDT10, AtNUDT2, AtNUDT6, AtNUDT7, AtNUDX7, cADPR phosphohydrolase, CinA, cyclic ADPR phosphohydrolase, DR2204, EcADPRase, mNUDT5 protein, More, MT1739, MtADPRase, MutT/nudix family protein, NadM-Nudix, Ndx2, Ndx4, NMN adenylyltransferase/ADP-ribose pyrophosphatase, Nudix hydrolase, Nudix hydrolase 7, NUDT5, NUDT5 protein, NUDT9, NUDT9 protein, NUDT9alpha protein, NUDX2, NUDX7, NuhA, pyrophosphatase, adenosine diphosphoribose, submicromolar-K(m) ADP-ribose pyrophosphatase, TtADPRase, YSA1H, zgc:64213

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.13 ADP-ribose diphosphatase

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Results	in table
1	Activating Compound
11166	AA Sequence
1	CAS Registry Number
32	Cloned(Commentary)
17	Crystallization (Commentary)
101	Disease/ Diagnostics
3	Expression
15	General Information
1	IC50 Value
38	Inhibitors
91	kcat/KM [mM/s]
2	Ki Value [mM]
160	KM Value [mM]
11	Localization
58	Metals/Ions
22	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
160	Organism
4	Pathway
283	PDB ID
19	pH Optimum
6	pH Range
4	pI Value
84	Protein Variants
35	Purification (Commentary)
4	Reaction
1	Reaction Type
65	Reference
129	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
163	Substrates and Products (Substrate)
16	Subunits
121	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
142	Turnover Number [1/s]

pH Range

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pH Range on EC 3.6.1.13 - ADP-ribose diphosphatase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4.5 - 10

Homo sapiens

Q9UKK9

pH 4.5: about 55% of maximal activity, pH 10.0: about 50% of maximal activity, activity with ADP-mannose

655991

6 - 10

Homo sapiens

Q9UKK9

pH 6.0: about 25% of maximal activity, pH 10.0: about 60% of maximal activity, activity with ADP-ribose

655991

7 - 9

Homo sapiens

-

linearly decreasing activity profile from pH 7 to pH 9, with activity at pH 9 being 50% of that at pH 7

654805

7.5 - 10

Mus musculus

-

pH 7.5: about 60% of maximal activity with ADP-ribose, about 50% of maximal activity with ADP-mannose, pH 10.0: about 70% of maximal activity with activity with ADP-ribose or ADP-mannose

655991

7.5 - 9

Thermus thermophilus

Q84CU3

-

687404

8 - 10

Synechococcus sp.

Q83ZD0

pH 8.0: about 40% of maximal activity, pH 10.0: about 60% of maximal activity

654895