3.6.1.11: exopolyphosphatase
This is an abbreviated version!
For detailed information about exopolyphosphatase, go to the full flat file.
Word Map on EC 3.6.1.11
Reaction
Synonyms
40 kD exopolyphosphatase, 40-kDa-exopolyphosphatase, acid phosphoanhydride phosphohydrolase, CJJ81176_0377, CJJ81176_1251, CT0099, CT1713, ecPpx, exopoly(P)ase, ExopolyPase, exopolyphosphatase, exopolyphosphatase 1, exopolyphosphatase 2, Gra-Pase, h-prune, high molecular mass exopolyphosphatase, high molecular weight exopolyphosphatase, high-molecular exopolyphosphatase, LmPPX, major cytosolic exopolyphosphatase PPX1, membrane-bound exopolyphosphatase, metaphosphatase, More, Msed_0981, MT0516, NMB1467, nuclear exopolyphosphatase, Nudix hydrolase, paPpx, phosphatase, exopoly-, polyphosphate phosphatase, polyphosphate phosphohydrolase, polyphosphate-phosphohydrolase, Ppn1, PPX, Ppx protein, Ppx/GppA phosphatase, PPX1, PPX2, PPXI, PPXMsed, Rv0496, Tb927.5.4350, Tb927.6.2670, TbDcp2, TbNH2, TbNH4, vacuolar exopolyphosphatase, YHR201C, Za10_0559, ZmPPX
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Reference on EC 3.6.1.11 - exopolyphosphatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Curdova, E.; Jechova, V.; Hostalek, Z.
Properties of apyrase and inorganic pyrophosphatase in Streptomyces aureofaciens
Folia Microbiol. (Praha)
27
159-166
1982
Kitasatospora aureofaciens
Capaccio, L.C.M.; Callow, J.A.
The enzymes of polyphosphate metabolism in vesicular-arbuscular mycorrhizas
New Phytol.
91
81-91
1982
Funneliformis mosseae
-
Afansieva, T.P.; Kulaev, I.S.
Polyphosphate phosphohydrolase from Endomyces magnusii
Biochim. Biophys. Acta
321
336-347
1973
Magnusiomyces magnusii
Jungnickel, F.
Significance of repressible polyphosphate phosphohydrolase in yeast and higher plants
React. Mech. Control Prop. Phosphotransferases, Int. Symp. Meeting, Akad. Verl. Berlin
87-91
1971
Cyberlindnera jadinii, Lemna gibba, Lemna minor, Lemna trisulca, Riccia fluitans, Solanum tuberosum, Wolffia arrhiza
-
Piccinnni, E.; Coppellotti, O.
Inorganic phosphatases and phosphagen kinase in Euglena gracilis
Comp. Biochem. Physiol. B
57
281-284
1977
Euglena gracilis
-
Jungnickel, F.
Regulative properties of surface located hydrolases in Candida utilis and in some Lemnaceae
Abh. Akad. Wiss. DDR Abt. Math. Naturwiss. Techn. , 3N, Microb. Enzymprod.
421-426
1981
Cyberlindnera jadinii
-
Akiyama, M.; Crooke, E.; Kornberg, A.
An exopolyphosphatase of Escherichia coli. The enzyme and its ppx gene in a polyphosphate operon
J. Biol. Chem.
268
633-639
1993
Escherichia coli
Andreeva, N.A.; Kulakovskaya, T.V.; Kualev, I.S.
Purification and properties of exopolyphosphatase isolated from Saccharomyces cerevisiae vacuoles
FEBS Lett.
429
194-196
1998
Saccharomyces cerevisiae
Lorenz, B.; Mueller, W.E.G.; Kualev, I.S.; Schroeder, H.C.
Purification and characterization of an exopolyphosphatase from Saccharomyces cerevisiae
J. Biol. Chem.
269
22198-22204
1994
Saccharomyces cerevisiae
Wurst, H.; Kornberg, A.
A soluble exopolyphosphatase of Saccharomyces cerevisiae. Purification and characterization
J. Biol. Chem.
269
10996-11001
1994
Saccharomyces cerevisiae
Keasling, J.D.; Bertsch, L.; Kornberg, A.
Guanosine pentaphosphate phosphohydrolase of Escherichia coli is a long-chain exopolyphosphatase
Proc. Natl. Acad. Sci. USA
90
7029-7033
1993
Escherichia coli
Kulakovskaya, T.V.; Andreeva, N.A.; Kualev, I.S.
Adenosine-5'-tetraphosphate and guanosine-5'-tetraphosphate: new substrates of the cytosolic exopolyphosphatase of the yeast Saccharomyces cerevisiae
Biochemistry
62
1051-1052
1997
Saccharomyces cerevisiae
Bolesch, D.G.; Keasling, J.D.
The effect of monovalent ions on polyphosphate binding to Escherichia coli exopolyphosphatase
Biochem. Biophys. Res. Commun.
274
236-241
2000
Escherichia coli
Lorenz, B.; Batel, R.; Bachinski, N.; Mueller, W.E.G.; Schroeder, H.C.
Purification and characterization of two exopolyphosphatases from the marine sponge Tethya lyncurium
Biochim. Biophys. Acta
1245
17-28
1995
Tethya aurantium
Guranowski, A.; Starzynska, E.; Barnes, L.D.; Robinson, A.K.; Liu, S.
Adenosine 5'-tetraphosphate phosphohydrolase activity is an inherent property of soluble exopolyphosphatase from yeast Saccharomyces cerevisiae
Biochim. Biophys. Acta
1380
232-238
1998
Saccharomyces cerevisiae
Lichko, L.P.; Kulakovskaya, T.V.; Kulaev, I.S.
Partial purification and characterization of nuclear exopolyphosphatase from Saccharomyces cerevisiae strain with inactivated PPX1 gene encoding a major yeast exopolyphosphatase
Biochemistry
69
270-274
2004
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P38698), Saccharomyces cerevisiae CRX
Andreeva, N.A.; Kulakovskaya, T.V.; Kulaev, I.S.
Purification and properties of exopolyphosphatase from the cytosol of Saccharomyces cerevisiae not encoded by the PPX1 gene
Biochemistry
69
387-393
2004
Saccharomyces cerevisiae, Saccharomyces cerevisiae VKM Y-1173
Lichko, L.; Kulakovskaya, T.; Kulaev, I.
Effect of PPX1 inactivation on exopolyphosphatases of different cell compartments of the yeast Saccharomyces cerevisiae
Biochim. Biophys. Acta
1599
102-105
2002
Saccharomyces cerevisiae
Lichko, L.; Kulakovskaya, T.; Kulaev, I.
Inactivation of endopolyphosphatase gene PPN1 results in inhibition of expression of exopolyphosphatase PPX1 and high-molecular-mass exopolyphosphatase not encoded by PPX1 in Saccharomyces cerevisiae
Biochim. Biophys. Acta
1674
98-102
2004
Saccharomyces cerevisiae
Rodrigues, C.O.; Ruiz, F.A.; Vieira, M.; Hill, J.E.; Docampo, R.
An acidocalcisomal exopolyphosphatase from Leishmania major with high affinity for short chain polyphosphate
J. Biol. Chem.
277
50899-50906
2002
Leishmania major
Proudfoot, M.; Kuznetsova, E.; Brown, G.; Rao, N.N.; Kitagawa, M.; Mori, H.; Savchenko, A.; Yakunin, A.F.
General Enzymatic Screens Identify Three New Nucleotidases in Escherichia coli. Biochemical Characterization of SurE, YfbR, and Yjjg
J. Biol. Chem.
279
54687-54694
2004
Escherichia coli (P0A840)
Lichko, L.P.; Kulakovskaya, T.V.; Kulaev, I.S.
Two exopolyphosphatases of Microlunatus phosphovorus, a polyphosphate-accumulating eubacterium from activated sludge
Process Biochem.
37
799-803
2002
Microlunatus phosphovorus
-
Zago, A.; Chugani, S.; Chakrabarty, A.M.
Cloning and characterization of polyphosphate kinase and exopolyphosphatase genes from Pseudomonas aeruginosa 8830
Appl. Environ. Microbiol.
65
2065-2071
1999
Pseudomonas aeruginosa (Q9S605), Pseudomonas aeruginosa, Pseudomonas aeruginosa 8830 (Q9S605), Pseudomonas aeruginosa 8830
Kulakovskaya, T.V.; Andreeva, N.A.; Trilisenko, L.V.; Suetin, S.V.; Vagabov, V.M.; Kulaev, I.S.
Accumulation of polyphosphates and expression of high molecular weight exopolyphosphatase in the yeast Saccharomyces cerevisiae
Biochemistry
70
980-985
2005
Saccharomyces cerevisiae, Saccharomyces cerevisiae VKM Y-1173
Andreeva, N.A.; Kulakovskaya, T.V.; Kulaev, I.S.
High Molecular Mass Exopolyphosphatase from the Cytosol of the Yeast Saccharomyces cerevisiae Is Encoded by the PPN1 Gene
Biochemistry (Moscow)
71
975-977
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae VKM Y-1173
Lichko, L.; Kulakovskaya, T.; Pestov, N.; Kulaev, I.
Inorganic polyphosphates and exopolyphosphatases in cell compartments of the yeast Saccharomyces cerevisiae under inactivation of PPX1 and PPN1 genes
Biosci. Rep.
26
45-54
2006
Saccharomyces cerevisiae
Pestov, N.A.; Kulakovskaya, T.V.; Kulaev, I.S.
Effects of inactivation of the PPN1 gene on exopolyphosphatases, inorganic polyphosphates and function of mitochondria in the yeast Saccharomyces cerevisiae
FEMS Yeast Res.
5
823-828
2005
Saccharomyces cerevisiae
Rangarajan, E.S.; Nadeau, G.; Li, Y.; Wagner, J.; Hung, M.N.; Schrag, J.D.; Cygler, M.; Matte, A.
The structure of the exopolyphosphatase (PPX) from Escherichia coli O157:H7 suggests a binding mode for long polyphosphate chains
J. Mol. Biol.
359
1249-1260
2006
Escherichia coli
Kulakovskaya, T.V.; Trilisenko, L.V.; Lichko, L.P.; Vagabov, V.M.; Kulaev, I.S.
The effect of inactivation of the exo- and endopolyphosphatase genes PPX1 and PPN1 on the level of different polyphosphates in the yeast Saccharomyces cerevisiae
Microbiology
75
25-28
2006
Saccharomyces cerevisiae
-
Lichko, L.P.; Kulakovskaya, T.V.; Pestov, N.A.; Kulaev, I.S.
Inactivation of the PPN1 gene exerts different effects on the metabolism of inorganic polyphosphates in the cytosol and the vacuoles of the yeast Saccharomyces cerevisiae
Microbiology
75
253-258
2006
Saccharomyces cerevisiae
-
Kulakovskaya, T.V.; Andreeva, N.A.; Trilisenko, L.V.; Vagabov, V.M.; Kulaev, I.S.
Two exopolyphosphatases in Saccharomyces cerevisiae cytosol at different culture conditions
Process Biochem.
39
1625-1630
2004
Saccharomyces cerevisiae
-
Alvarado, J.; Ghosh, A.; Janovitz, T.; Jauregui, A.; Hasson, M.S.; Sanders, D.A.
Origin of exopolyphosphatase processivity: Fusion of an ASKHA phosphotransferase and a cyclic nucleotide phosphodiesterase homolog
Structure
14
1263-1272
2006
Escherichia coli
Cardona, S.T.; Chavez, F.P.; Jerez, C.A.
The exopolyphosphatase gene from Sulfolobus solfataricus: characterization of the first gene found to be involved in polyphosphate metabolism in archaea
Appl. Environ. Microbiol.
68
4812-4819
2002
Saccharolobus solfataricus (Q97YV9), Saccharolobus solfataricus
Lichko, L.P.; Kulakovskaya, T.V.; Kulaev, I.S.
Inorganic polyphosphates and exopolyphosphatases in different cell compartments of Saccharomyces cerevisiae
Biochemistry (Moscow)
71
1171-1175
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae CRY
Andreeva, N.A.; Kulakovskaya, T.V.; Kulakovskaya, E.V.; Kulaev, I.S.
Polyphosphates and exopolyphosphatases in cytosol and mitochondria of Saccharomyces cerevisiae during growth on glucose or ethanol under phosphate surplus
Biochemistry (Moscow)
73
65-69
2008
Saccharomyces cerevisiae
Campos, E.; Facanha, A.; Moraes, J.; da Silva Vaz, I.; Masuda, A.; Logullo, C.
A mitochondrial exopolyphosphatase activity modulated by phosphate demand in Rhipicephalus (Boophilus) microplus embryo
Insect Biochem. Mol. Biol.
37
1103-1107
2007
Rhipicephalus microplus
Fang, J.; Ruiz, F.A.; Docampo, M.; Luo, S.; Rodrigues, J.C.; Motta, L.S.; Rohloff, P.; Docampo, R.
Overexpression of a Zn2+-sensitive soluble exopolyphosphatase from Trypanosoma cruzi depletes polyphosphate and affects osmoregulation
J. Biol. Chem.
282
32501-32510
2007
Trypanosoma cruzi (Q6Y656), Trypanosoma cruzi
Tammenkoski, M.; Moiseev, V.M.; Lahti, M.; Ugochukwu, E.; Brondijk, T.H.; White, S.A.; Lahti, R.; Baykov, A.A.
Kinetic and mutational analyses of the major cytosolic exopolyphosphatase from Saccharomyces cerevisiae
J. Biol. Chem.
282
9302-9311
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae AH22
Ugochukwu, E.; Lovering, A.L.; Mather, O.C.; Young, T.W.; White, S.A.
The crystal structure of the cytosolic exopolyphosphatase from Saccharomyces cerevisiae reveals the basis for substrate specificity
J. Mol. Biol.
371
1007-1021
2007
Saccharomyces cerevisiae
Lichko, L.P.; Kulakovskaya, T.V.; Kulaev, I.S.
Inorganic polyphosphate and exopolyphosphatase in the nuclei of Saccharomyces cerevisiae: dependence on the growth phase and inactivation of the PPX1 and PPN1 genes
Yeast
23
735-740
2006
Saccharomyces cerevisiae
Lichko, L.P.; Kulakovskaya, T.V.; Kulakovskaya, E.V.; Kulaev, I.S.
Inactivation of PPX1 and PPN1 genes encoding exopolyphosphatases of Saccharomyces cerevisiae does not prevent utilization of polyphosphates as phosphate reserve
Biochemistry (Moscow)
73
985-989
2008
Saccharomyces cerevisiae
Tammenkoski, M.; Koivula, K.; Cusanelli, E.; Zollo, M.; Steegborn, C.; Baykov, A.A.; Lahti, R.
Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase
Biochemistry
47
9707-9713
2008
Homo sapiens
Campos, E.; Facanha, A.R.; Costa, E.P.; da Silva Vaz, I.; Masuda, A.; Logullo, C.
Exopolyphosphatases in nuclear and mitochondrial fractions during embryogenesis of the hard tick Rhipicephalus (Boophilus) microplus
Comp. Biochem. Physiol. B
151
311-316
2008
Rhipicephalus microplus
Lindner, S.N.; Knebel, S:; Wesseling,H.; Schoberth, S.M.; Wendisch, V.F.
Exopolyphosphatases PPX1 and PPX2 from Corynebacterium glutamicum[down-pointing small open triangle]
Appl. Environ. Microbiol.
75
3161-3170
2009
Corynebacterium glutamicum (Q8NRR8), Corynebacterium glutamicum (Q8NT99), Corynebacterium glutamicum
Varela, C.; Mauriaca, C.; Paradela, A.; Albar, J.P.; Jerez, C.A.; Chavez, F.P.
New structural and functional defects in polyphosphate deficient bacteria: A cellular and proteomic study
BMC Microbiol.
10
7-7
2010
Pseudomonas sp.
Luginbuehl, E.; Kunz, S.; Wentzinger, L.; Freimoser, F.; Seebeck, T.
The exopolyphosphatase TbrPPX1 of Trypanosoma brucei
BMC Microbiol.
11
4-4
2011
Trypanosoma brucei (Q7Z032), Trypanosoma brucei, Trypanosoma brucei 427 (Q7Z032)
Zhang, Q.; Li, Y.; Tang, C.M.
The role of the exopolyphosphatase PPX in avoidance by Neisseria meningitidis of complement-mediated killing
J. Biol. Chem.
285
34259-34268
2010
Neisseria meningitidis
Campos, E.; Facanha, A.R.; Costa, E.P.; Fraga, A.; Moraes, J.; da Silva Vaz, I.; Masuda, A.; Logullo, C.
A mitochondrial membrane exopolyphosphatase is modulated by, and plays a role in, the energy metabolism of hard tick Rhipicephalus (Boophilus) microplus embryos
Int. J. Mol. Sci.
12
3525-3535
2011
Rhipicephalus microplus
Thayil, S.M.; Morrison, N.; Schechter, N.; Rubin, H.; Karakousis, P.C.
The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence
PLoS ONE
6
e28076
2011
Mycobacterium tuberculosis (P9WHV4), Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC 1551 (P9WHV4)
Remonsellez, F.; Orell, A.; Jerez, C.A.
Copper tolerance of the thermoacidophilic archaeon Sulfolobus metallicus: possible role of polyphosphate metabolism
Microbiology
152
59-66
2006
Sulfuracidifex metallicus, Sulfuracidifex metallicus DSM 6482
Andreeva, N.; Trilisenko, L.; Kulakovskaya, T.; Dumina, M.; Eldarov, M.
Purification and properties of recombinant exopolyphosphatase PPN1 and effects of its overexpression on polyphosphate in Saccharomyces cerevisiae
J. Biosci. Bioeng.
119
52-56
2015
Saccharomyces cerevisiae (Q04119), Saccharomyces cerevisiae
Albi, T.; Serrano, A.
Two exopolyphosphatases with distinct molecular architectures and substrate specificities from the thermophilic green-sulfur bacterium Chlorobium tepidum TLS
Microbiology
160
2067-2078
2014
Chlorobaculum tepidum (Q8KBS0), Chlorobaculum tepidum (Q8KG69), Chlorobaculum tepidum DSM 12025 (Q8KBS0), Chlorobaculum tepidum DSM 12025 (Q8KG69)
Gallarato, L.A.; Sanchez, D.G.; Olvera, L.; Primo, E.D.; Garrido, M.N.; Beassoni, P.R.; Morett, E.; Lisa, A.T.
Exopolyphosphatase of Pseudomonas aeruginosa is essential for the production of virulence factors, and its expression is controlled by NtrC and PhoB acting at two interspaced promoters
Microbiology
160
406-417
2014
Pseudomonas aeruginosa (Q9ZN70), Pseudomonas aeruginosa
Andreeva, N.; Trilisenko, L.; Eldarov, M.; Kulakovskaya, T.
Polyphosphatase PPN1 of Saccharomyces cerevisiae: switching of exopolyphosphatase and endopolyphosphatase activities
PLoS ONE
10
e0119594
2015
Saccharomyces cerevisiae (Q04119), Saccharomyces cerevisiae
Choi, M.Y.; Wang, Y.; Wong, L.L.; Lu, B.T.; Chen, W.Y.; Huang, J.D.; Tanner, J.A.; Watt, R.M.
The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities
PLoS ONE
7
e42561
2012
Mycobacterium tuberculosis (P9WHV5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WHV5)
Malde, A.; Gangaiah, D.; Chandrashekhar, K.; Pina-Mimbela, R.; Torrelles, J.B.; Rajashekara, G.
Functional characterization of exopolyphosphatase/guanosine pentaphosphate phosphohydrolase (PPX/GPPA) of Campylobacter jejuni
Virulence
5
521-533
2014
Campylobacter jejuni (A0A0H3PAT6), Campylobacter jejuni (A0A0H3PES2), Campylobacter jejuni 81-176 (A0A0H3PAT6), Campylobacter jejuni 81-176 (A0A0H3PES2)
Zhang, A.; Guo, E.; Qian, L.; Tang, N.Y.; Watt, R.M.; Bartlam, M.
Purification, crystallization and X-ray crystallographic analysis of a putative exopolyphosphatase from Zymomonas mobilis
Acta Crystallogr. Sect. F
72
172-178
2016
Zymomonas mobilis (A0A542W0V0), Zymomonas mobilis, Zymomonas mobilis NCIMB 11163 (A0A542W0V0)
Boetsch, C.; Aguayo-Villegas, D.R.; Gonzalez-Nilo, F.D.; Lisa, A.T.; Beassoni, P.R.
Putative binding mode of Escherichia coli exopolyphosphatase and polyphosphates based on a hybrid in silico/biochemical approach
Arch. Biochem. Biophys.
606
64-72
2016
Escherichia coli (P0AFL6), Escherichia coli
Rivero, M.; Torres-Paris, C.; Munoz, R.; Cabrera, R.; Navarro, C.A.; Jerez, C.A.
Inorganic polyphosphate, exopolyphosphatase, and Pho84-like transporters may be involved in copper resistance in Metallosphaera sedula DSM 5348T
Archaea
2018
5251061
2018
Metallosphaera sedula (A4YFE8), Metallosphaera sedula, Metallosphaera sedula NBRC 15509 (A4YFE8), Metallosphaera sedula TH2 (A4YFE8), Metallosphaera sedula JCM 9185 (A4YFE8), Metallosphaera sedula DSM 5348 (A4YFE8), Metallosphaera sedula ATCC 51363 (A4YFE8)
Andreeva, N.; Ledova, L.; Ryazanova, L.; Tomashevsky, A.; Kulakovskaya, T.; Eldarov, M.
Ppn2 endopolyphosphatase overexpressed in Saccharomyces cerevisiae Comparison with Ppn1, Ppx1, and Ddp1 polyphosphatases
Biochimie
163
101-107
2019
Saccharomyces cerevisiae (P38698), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P38698)
Cordeiro, C.D.; Ahmed, M.A.; Windle, B.; Docampo, R.
NUDIX hydrolases with inorganic polyphosphate exo- and endopolyphosphatase activities in the glycosome, cytosol and nucleus of Trypanosoma brucei
Biosci. Rep.
39
BSR20190894
2019
Trypanosoma brucei brucei (Q57Z14), Trypanosoma brucei brucei (Q583R7), Trypanosoma brucei brucei 927/4 GUTat10.1 (Q57Z14), Trypanosoma brucei brucei 927/4 GUTat10.1 (Q583R7)
Beassoni, P.R.; Gallarato, L.A.; Boetsch, C.; Garrido, M.N.; Lisa, A.T.
Pseudomonas aeruginosa exopolyphosphatase is also a polyphosphate ADP phosphotransferase
Enzyme Res.
2015
404607
2015
Pseudomonas aeruginosa
Cruz, C.S.; Costa, E.P.; Machado, J.A.; Silva, J.N.; Romeiro, N.C.; Moraes, J.; Silva, J.R.; Fonseca, R.N.; Vaz, I.S.; Logullo, C.; Campos, E.
A soluble inorganic pyrophosphatase from the cattle tick Rhipicephalus microplus capable of hydrolysing polyphosphates
Insect Mol. Biol.
27
260-267
2018
Rhipicephalus microplus
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