3.6.1.11: exopolyphosphatase

This is an abbreviated version!
For detailed information about exopolyphosphatase, go to the full flat file.

Reaction

Synonyms

40 kD exopolyphosphatase, 40-kDa-exopolyphosphatase, acid phosphoanhydride phosphohydrolase, CJJ81176_0377, CJJ81176_1251, CT0099, CT1713, ecPpx, exopoly(P)ase, ExopolyPase, exopolyphosphatase, exopolyphosphatase 1, exopolyphosphatase 2, Gra-Pase, h-prune, high molecular mass exopolyphosphatase, high molecular weight exopolyphosphatase, high-molecular exopolyphosphatase, LmPPX, major cytosolic exopolyphosphatase PPX1, membrane-bound exopolyphosphatase, metaphosphatase, More, Msed_0981, MT0516, NMB1467, nuclear exopolyphosphatase, Nudix hydrolase, paPpx, phosphatase, exopoly-, polyphosphate phosphatase, polyphosphate phosphohydrolase, polyphosphate-phosphohydrolase, Ppn1, PPX, Ppx protein, Ppx/GppA phosphatase, PPX1, PPX2, PPXI, PPXMsed, Rv0496, Tb927.5.4350, Tb927.6.2670, TbDcp2, TbNH2, TbNH4, vacuolar exopolyphosphatase, YHR201C, Za10_0559, ZmPPX

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.11 exopolyphosphatase

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Results	in table
20	Activating Compound
12781	AA Sequence
1	CAS Registry Number
25	Cloned(Commentary)
4	Crystallization (Commentary)
35	Disease/ Diagnostics
7	Expression
48	General Information
7	General Stability
15	IC50 Value
118	Inhibitors
23	kcat/KM [mM/s]
7	Ki Value [mM]
111	KM Value [mM]
58	Localization
111	Metals/Ions
44	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
110	Organism
5	Pathway
46	PDB ID
31	pH Optimum
8	pH Range
7	pH Stability
1	pI Value
1	Posttranslational Modification
52	Protein Variants
30	Purification (Commentary)
4	Reaction
12	Reaction Type
90	Reference
11	Source Tissue
64	Specific Activity [micromol/min/mg]
11	Storage Stability
219	Substrates and Products (Substrate)
30	Subunits
167	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
3	Temperature Range [°C]
8	Temperature Stability [°C]
69	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.6.1.11 - exopolyphosphatase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(phosphate)n + H2O

(phosphate)n-1 + phosphate

5 entries

(polyphosphate)n + H2O

(polyphosphate)n-1 + phosphate

5 entries

polyphosphate60 + H2O

polyphosphate59 + phosphate

2 entries

polyphosphate700 + H2O

polyphosphate699 + phosphate

2 entries

additional information

?

-

8 entries

(phosphate)n + H2O

(phosphate)n-1 + phosphate

Corynebacterium glutamicum

Q8NRR8, Q8NT99

degradation of polyphosphate

701387

-

-

?

(phosphate)n + H2O

(phosphate)n-1 + phosphate

Homo sapiens

-

h-prune efficiently hydrolyzes short-chain polyphosphates

696296

-

-

?

(phosphate)n + H2O

(phosphate)n-1 + phosphate

Rhipicephalus microplus

-

regulatory enzyme in polyphosphate metabolism

697460

-

-

?

(phosphate)n + H2O

(phosphate)n-1 + phosphate

Saccharomyces cerevisiae

-

-

685297, 685307, 688364, 690206

-

-

?

(phosphate)n + H2O

(phosphate)n-1 + phosphate

Saccharomyces cerevisiae CRY

-

-

685297

-

-

?

(polyphosphate)n + H2O

(polyphosphate)n-1 + phosphate

Cyberlindnera jadinii

-

phosphate starvation induces the formation of the enzyme

209843

-

-

?

(polyphosphate)n + H2O

(polyphosphate)n-1 + phosphate

Cyberlindnera jadinii

-

enzyme is derepressed under phosphate starvation conditions

209841

-

-

?

(polyphosphate)n + H2O

(polyphosphate)n-1 + phosphate

Neisseria meningitidis

-

-

712478

-

-

?

(polyphosphate)n + H2O

(polyphosphate)n-1 + phosphate

Pseudomonas sp.

-

-

702901

-

-

ir

(polyphosphate)n + H2O

(polyphosphate)n-1 + phosphate

Tethya aurantium

-

the inhibitory effect of long-chain polyphosphates on adenylate kinase is higher than that of short-chain polyphosphates, suggesting a potential role of polyphosphate metabolism in regulating intracellular concentration of adenylate nucleotides

209851

-

-

?

polyphosphate60 + H2O

polyphosphate59 + phosphate

Trypanosoma brucei brucei

Q57Z14, Q583R7

-

756231

-

-

?

polyphosphate60 + H2O

polyphosphate59 + phosphate

Trypanosoma brucei brucei 927/4 GUTat10.1

Q57Z14, Q583R7

-

756231

-

-

?

polyphosphate700 + H2O

polyphosphate699 + phosphate

Trypanosoma brucei brucei

Q57Z14, Q583R7

-

756231

-

-

?

polyphosphate700 + H2O

polyphosphate699 + phosphate

Trypanosoma brucei brucei 927/4 GUTat10.1

Q57Z14, Q583R7

-

756231

-

-

?

additional information

?

-

Escherichia coli

P0AFL6

exopolyphosphatase Ppx releases inorganic phosphate (Pi) from polyphosphate. Inorganic polyphosphate (polyP) is a linear anionic polymer of phosphate molecules which was found in all living organisms and may form aggregates. The phosphate molecules within polyphosphate are held together by high-energy phosphoanhydride bonds. The length of this polymer may vary between ten to hundreds of units, depending on the organism and its physiological stage

755891

-

-

-

additional information

?

-

Escherichia coli

-

exopolyphosphatase Ppx releases inorganic phosphate (Pi) from polyphosphate. Inorganic polyphosphate (polyP) is a linear anionic polymer of phosphate molecules which was found in all living organisms and may form aggregates. The phosphate molecules within polyphosphate are held together by high-energy phosphoanhydride bonds. The length of this polymer may vary between ten to hundreds of units, depending on the organism and its physiological stage

755891

-

-

-

additional information

?

-

Homo sapiens

-

h-prune is the missing exopolyphosphatase in animals and support the hypothesis that the metastatic effects of h-prune are modulated by inorganic polyphosphates, which are increasingly recognized as critical regulators in cells

696296

-

-

?

additional information

?

-

Rhipicephalus microplus

-

the soluble enzyme from cattle tick Rhipicephalus microplus is capable of hydrolysing polyphosphates, molecular docking assays of RmPPase with polyphosphates, and molecular modelling, overview

756916

-

-

-

additional information

?

-

Saccharomyces cerevisiae

-

PPN1 splitting long polyphosphate chains to shorter ones

696170

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

PPX1 splitting off phosphate from the end of the polyphosphate chain

696170

-

-

?

additional information

?

-

Trypanosoma cruzi

Q6Y656

polyphosphates play a role in the parasite's osmoregulation, overview

687628

-

-

?

additional information

?

-

Trypanosoma cruzi

-

polyphosphates play a role in the parasite's osmoregulation, overview

687628

-

-

?