3.6.1.1: inorganic diphosphatase

This is an abbreviated version!
For detailed information about inorganic diphosphatase, go to the full flat file.

Reaction

Synonyms

acid PPase, AT727_13205, AtPPA1, AtPPsPase1, BT2127, CBS-PPase, CBS-PPase1, chloroplast inorganic pyrophosphatase 1, class A type PPA, cobalt-dependent inorganic pyrophosphatase, CPE2055, cytosolic PPase, D1C enzyme, dhPPase, E-PPase, EcPpA, EcPPiase, ehPPase, family I inorganic pyrophosphatase, family I PPase, family I pyrophosphatase, family II inorganic pyrophosphatase, family II PPase, H+-PPase, H+-pyrophosphatase, H+-translocating/vacuolar inorganic pyrophosphatase, Hpp1 protein, HVO_0729, HvPPA, hyperthermophilic inorganic pyrophosphatase, inorganic diphosphatase, inorganic PPase, inorganic pyrophosphatase, inorganic pyrophosphatase 1, inorganic pyrophosphatase-like protein, inorganic pyrophosphorylase, IPP, IPP1, Ipp1p, IPPase, LHPPase, M-PPase, manganese-dependent inorganic pyrophosphatase, MazG, MdPPa, membrane-integral inorganic pyrophosphatase, membrane-integral pyrophosphatase, miPPase, mitochondrial pyrophosphatase, Mn2+-bound canonical Family II PPase, More, Mtb PPiase, Mthe_0236, MtPPA1, MtPPiase, nucleotide-regulated pyrophosphatase, OVP1, p26.1a, p26.1b, PfPPase, PH1907, Pho-PPase, phospholysine phosphohistidine inorganic pyrophosphate phosphatase, phosphoprotein p26.1, PPA, PPA1, PpaC, PPase, PPase 1, PPase 2, ppase-1, PPase-2, PPase1, PPase2, PPase4, PPias, PPIase, proton-translocating inorganic pyrophosphatase, PYP-1, pyrophosphatase, pyrophosphatase, inorganic, Pyrophosphate phospho-hydrolase, pyrophosphate phospho-hydrolase 1, Pyrophosphate phosphohydrolase, Pyrophosphate-energized inorganic pyrophosphatase, RmPPase, Rv3628, siPPiase, soluble inorganic pyrophosphatase, soluble inorganic pyrophosphatase 2, soluble pyrophosphatase, soluble-type yeast PPase, sPPAse, ST2226, Tc-sPPase, TC004566, TcasGA2_TC004566, TgPPase, ThPP1, Tm-PPase, TM0913, V-PPase, vacuolar H(+)-PPase, vacuolar H(+)-pyrophosphatase, vacuolar H+-pyrophosphatase, vacuolar H+-translocating inorganic pyrophosphatase, vacuolar H+-translocating pyrophosphatase, vacuolar pyrophosphatase, VHP, VP1, VSP, VVPP1

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.1 inorganic diphosphatase

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Results	in table
23	Activating Compound
50600	AA Sequence
5	Application
1	CAS Registry Number
80	Cloned(Commentary)
31	Crystallization (Commentary)
425	Disease/ Diagnostics
10	Expression
110	General Information
6	General Stability
13	IC50 Value
380	Inhibitors
38	kcat/KM [mM/s]
10	Ki Value [mM]
189	KM Value [mM]
158	Localization
310	Metals/Ions
136	Molecular Weight [Da]
193	Natural Substrates/ Products (Substrates)
9	Organic Solvent Stability
358	Organism
5	Pathway
333	PDB ID
104	pH Optimum
21	pH Range
3	pH Stability
11	pI Value
10	Posttranslational Modification
213	Protein Variants
99	Purification (Commentary)
6	Reaction
1	Reaction Type
241	Reference
3	Renatured (Commentary)
117	Source Tissue
62	Specific Activity [micromol/min/mg]
12	Storage Stability
419	Substrates and Products (Substrate)
141	Subunits
402	Synonyms
1	Systematic Name
58	Temperature Optimum [°C]
16	Temperature Range [°C]
45	Temperature Stability [°C]
105	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.6.1.1 - inorganic diphosphatase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0574

3-(3-(3-(3-chlorophenyl)pyrrolidin-1-yl)-1,2,4-triazin-5-yl)aniline

Mycobacterium tuberculosis

P9WI55

at pH 7.5 and 37°C

733503

0.0632

3-(3-(3-(benzyloxy)phenyl)pyrrolidin-1-yl)-5-(5-methylfuran-2-yl)-1,2,4-triazine

Mycobacterium tuberculosis

P9WI55

at pH 7.5 and 37°C

733503

0.0532

3-(3-(3-chlorophenyl)pyrrolidin-1-yl)-5-(3,4-dimethoxyphenyl)-1,2,4-triazine

Mycobacterium tuberculosis

P9WI55

at pH 7.5 and 37°C

733503

0.1182

3-(3-(3-chlorophenyl)pyrrolidin-1-yl)-5-(3-nitrophenyl)-1,2,4-triazine

Mycobacterium tuberculosis

P9WI55

at pH 7.5 and 37°C

733503

0.0383

3-(3-(3-chlorophenyl)pyrrolidin-1-yl)-5-(5-(2-(trifluoromethyl)phenyl)furan-2-yl)-1,2,4-triazine

Mycobacterium tuberculosis

P9WI55

at pH 7.5 and 37°C

733503

0.1015

3-(3-(3-chlorophenyl)pyrrolidin-1-yl)-5-phenyl-1,2,4-triazine

Mycobacterium tuberculosis

P9WI55

at pH 7.5 and 37°C

733503

0.1475

3-[3-(3-chlorophenyl)pyrrolidin-1-yl]-5-(5-methylfuran-2-yl)-1,2,4-triazine

Mycobacterium tuberculosis

P9WI55

at pH 7.5 and 37°C

733503

0.0881

4-(3-(3-(3-chlorophenyl)pyrrolidin-1-yl)-1,2,4-triazin-5-yl)aniline

Mycobacterium tuberculosis

P9WI55

at pH 7.5 and 37°C

733503

0.0333

5-(4-bromophenyl)-3-(3-(3-chlorophenyl)pyrrolidin-1-yl)-1,2,4-triazine

Mycobacterium tuberculosis

P9WI55

at pH 7.5 and 37°C

733503

0.3545

5-(5-methylfuran-2-yl)-3-(3-(3-(trifluoromethyl)phenyl)pyrrolidin-1-yl)-1,2,4-triazine

Mycobacterium tuberculosis

P9WI55

at pH 7.5 and 37°C

733503

0.1

fluoride

Pyrococcus horikoshii

O59570

potent inhibition, IC50: 0.1 mM

667352

17.2

GSH

Helicobacter pylori

P56153

pH 8.0, 37°C, recombinant wild-type enzyme

684755

1.11

SDS

Thermus thermophilus

P38576

at 25°C, pH not specified in the publication

712191