3.5.5.1: nitrilase

This is an abbreviated version!
For detailed information about nitrilase, go to the full flat file.

Reaction

Synonyms

3-cyanopyridinase, acetonitrilase, Arylacetonitrilase, auxin-producing nitrilase, benzonitrilase, benzonitrilase A, benzonitrilase B, bll6402, BrNIT-T, CrNIT1, CrNIT2, cyc705, CynD, humanNIT1, More, nirilase II, NIT, NIT-T2, Nit06, NIT1, Nit1 nitrilase, Nit102, NIT2, NIT3, NIT4A/B1, NIT4A/B2, NitA, NitAk1, nitmc-fb, NitraS-ATII, nitrilase, nitrilase 1, nitrilase AtNIT1, nitrilase bll6402, nitrilase I, nitrile hydratase/amidase, Nlase, PaCNit, SsAH, SSO2122

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.5 In nitriles

                3.5.5.1 nitrilase

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Results	in table
22	Activating Compound
841	AA Sequence
74	Application
7	CAS Registry Number
54	Cloned(Commentary)
1	Crystallization (Commentary)
23	Disease/ Diagnostics
10	Expression
77	General Information
12	General Stability
241	Inhibitors
31	kcat/KM [mM/s]
3	Ki Value [mM]
148	KM Value [mM]
16	Localization
21	Metals/Ions
104	Molecular Weight [Da]
85	Natural Substrates/ Products (Substrates)
49	Organic Solvent Stability
572	Organism
10	Pathway
24	PDB ID
83	pH Optimum
28	pH Range
20	pH Stability
3	pI Value
5	Posttranslational Modification
147	Protein Variants
60	Purification (Commentary)
7	Reaction
5	Reaction Type
336	Reference
2	Renatured (Commentary)
44	Source Tissue
73	Specific Activity [micromol/min/mg]
3	Storage Stability
1017	Substrates and Products (Substrate)
108	Subunits
79	Synonyms
1	Systematic Name
73	Temperature Optimum [°C]
20	Temperature Range [°C]
59	Temperature Stability [°C]
66	Turnover Number [1/s]

Disease

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Disease on EC 3.5.5.1 - nitrilase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Colonic Neoplasms

Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways.

25738796

Infections

Alternative transcription initiation of the nitrilase gene (BrNIT2) caused by infection with Plasmodiophora brassicae Woron. in Chinese cabbage (Brassica rapa L.).

18726557

Infections

Expression and localization of nitrilase during symptom development of the clubroot disease in Arabidopsis.

10677430

Infections

Proteomics and functional analyses of Arabidopsis nitrilases involved in the defense response to microbial pathogens.

27095107

Neoplasms

Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways.

25738796

Neoplasms

Nitrilase 1 modulates lung tumor progression in vitro and in vivo.

26967383

Rubella

Substrate specificity of plant nitrilase complexes is affected by their helical twist.

30417123

Starvation

A role for nitrilase 3 in the regulation of root morphology in sulphur-starving Arabidopsis thaliana.

11967096

Tuberculosis

Glutamine amidotransferase activity of NAD+ synthetase from Mycobacterium tuberculosis depends on an amino-terminal nitrilase domain.

15748981

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