3.5.5.1: nitrilase
This is an abbreviated version!
For detailed information about nitrilase, go to the full flat file.
Word Map on EC 3.5.5.1
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3.5.5.1
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enantioselectivity
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amidase
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hydratase
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rhodococcus
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biocatalyst
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synthesis
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rhodochrous
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benzonitrile
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mandelonitrile
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indole-3-acetic
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alcaligenes
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indole-3-acetonitrile
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3-cyanopyridine
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dinitriles
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phenylacetonitrile
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acrylonitrile
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bromoxynil
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r-mandelic
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nhase
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acidovorax
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ozaenae
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facilis
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industry
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iminodiacetic
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gibberella
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analysis
- 3.5.5.1
-
enantioselectivity
- amidase
-
hydratase
- rhodococcus
-
biocatalyst
- synthesis
- rhodochrous
- benzonitrile
- mandelonitrile
-
indole-3-acetic
- alcaligenes
- indole-3-acetonitrile
- 3-cyanopyridine
-
dinitriles
- phenylacetonitrile
- acrylonitrile
- bromoxynil
-
r-mandelic
- nhase
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acidovorax
- ozaenae
- facilis
- industry
-
iminodiacetic
- gibberella
- analysis
Reaction
Synonyms
3-cyanopyridinase, acetonitrilase, Arylacetonitrilase, auxin-producing nitrilase, benzonitrilase, benzonitrilase A, benzonitrilase B, bll6402, BrNIT-T, CrNIT1, CrNIT2, cyc705, CynD, humanNIT1, More, nirilase II, NIT, NIT-T2, Nit06, NIT1, Nit1 nitrilase, Nit102, NIT2, NIT3, NIT4A/B1, NIT4A/B2, NitA, NitAk1, nitmc-fb, NitraS-ATII, nitrilase, nitrilase 1, nitrilase AtNIT1, nitrilase bll6402, nitrilase I, nitrile hydratase/amidase, Nlase, PaCNit, SsAH, SSO2122
ECTree
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
industry
synthesis
industry
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the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
industry
-
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
industry
-
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
industry
-
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
industry
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
industry
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
industry
-
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
industry
spore surface display of nitrilases is an effective approach for enzyme immobilization in biochemical engineering on an industrial scale
industry
-
the high-level production of Arthrobacter aurescens CYC705 nitrilase will meet the need of industrial biosynthesis of iminodiacetic acid
industry
the purified enzyme reveales its selectivity towards dinitriles, which suggests a possible industrial application in the synthesis of cyanocarboxylic acids
industry
-
the high-level production of Arthrobacter aurescens CYC705 nitrilase will meet the need of industrial biosynthesis of iminodiacetic acid
-
industry
Rhodococcus sp. NCIMB 11216
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the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
-
industry
-
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
-
industry
-
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
-
industry
-
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
-
industry
-
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
-
industry
-
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
-
industry
Rhodococcus sp. NCIMB 11215
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the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
-
industry
-
the high chemical specificity and frequent enantioselectivity of nitrilases makes them attractive biocatalysts for the production of fine chemicals and pharmaceutical intermediates. Nitrilases are also used in the treatment of toxic industrial effluent and cyanide remediation
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synthesis
nitrilase products are intermediates in the synthesis of nylon
synthesis
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preparing carboxylic acids from readily available nitrile analogues
synthesis
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enzyme can be used as a biocatalyst for the synthesis of a range of alpha-hydroxy carboxylic acids or amides from aldehydes in presence of cyanide, halting of the reaction at the amide intermediate by use of specific inhibitors is possible
synthesis
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biotransformation of benzonitrile to benzoic acid. The effect of whole cell immobilisation on the biotransformation of benzonitrile and the use of direct electric current for enhanced product removal
synthesis
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biotransformation of trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylonitrile to trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylic acid with isolated enzyme, immobilized enzyme and with recombinant cells containing AtNIT1
synthesis
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biotransformation of trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylonitrile to trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylic acid with isolated enzyme, immobilized enzyme and with recombinant cells containing AtNIT1
synthesis
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production of (R)-mandelic acid from racemic mandelonitrile using free and immobilized cells of Pseudomonas putida
synthesis
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attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
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attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
synthesis
-
synthesis of (R)-mandelic acid from (R,S)-mandelonitrile by use of Escherichia coli overexpressing the enzyme in a bioreactor. After a single batch reaction, (R)-mandelic acid can be obtained with 87% yield and 99.99% enantiomeric excess
synthesis
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synthesis of beta-hydroxy carboxylic acids with high yield and optical purity by reudction of aromatic beta-ketonitriles with recombinant carbonyl reductase and nitrilase-catalyzed hydrolysis
synthesis
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nitrilases are useful biocatalysts for the hydrolysis of nitriles in a mild and environmentally friendly manner assuring a clean process and specificity with high yield
synthesis
-
recombinant cells expressing the enzyme are promising catalysts for the synthesis of stable chiral quaternary carbon centers from ketones
synthesis
-
recombinant cells expressing the enzyme are promising catalysts for the synthesis of stable chiral quaternary carbon centers from ketones
synthesis
-
recombinant cells expressing the enzyme are promising catalysts for the synthesis of stable chiral quaternary carbon centers from ketones
synthesis
recombinant cells expressing the enzyme are promising catalysts for the synthesis of stable chiral quaternary carbon centers from ketones
synthesis
the enzyme is useful fpr synthesis of iminodiacetic acid, which is widely used as an intermediate in the manufacture of chelating agents, glyphosate herbicides and surfactants
synthesis
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a cascade reaction for the synthesis of optically pure (S)-beta-phenylalanine from benzoylacetonitrile was developed by coupling HpN with an omega-transaminase from Polaromonas sp. JS666 in toluene-water biphasic reaction system using beta-alanine as an amino donor. Various (S)-beta-amino acids can be produced from benzoylacetonitrile derivatives with moderate to high conversions (73-99%) and excellent enantioselectivity (above 99% enantiomeric exess). Great potential of this cascade reaction for the practical synthesis of (S)-beta-phenylalanine
synthesis
mutant nitrilase F168V/T201N/S192F/M191T/F192S is promising in applications for the upscale production of iminodiacetic acid
synthesis
Nitrilase-catalyzed regioselective hydrolysis of 1-cyanocyclohexaneacetonitrile is a green and efficient approach for the preparation of 1-cyanocyclohexaneacetic acid, a key precursor for the synthesis of gabapentin. The enzyme ecapsulated in ethyleneamine-mediated biosilica an be used as a biocatalyst for the development of an efficient biotransformation process for the synthesis of 1-cyanocyclohexaneacetic acid
synthesis
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Pseudomonas aeruginosa RZ44 has the potential to be applied in the biotransformation of nitrile compounds
synthesis
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the broad range of substrate specificity, the high activity towards aliphatic, aromatic, and arylacetonitriles, and the highly stability, in terms of temperature, pH, and metal ions make the enzyme a promising biocatalyst for mild nitrile hydrolysis
synthesis
-
the high-level production of Arthrobacter aurescens CYC705 nitrilase will meet the need of industrial biosynthesis of iminodiacetic acid
synthesis
the purified enzyme reveales its selectivity towards dinitriles, which suggests a possible industrial application in the synthesis of cyanocarboxylic acids
synthesis
-
the strain mut-D3, with higher toxic substrate tolerance and enhanced robustness to extraneous factors is obtained via several rounds of screening. The free or immobilized catalysts of mut-D3 could serve as a good choice for nicotinic acid production from 3-cyanopyridine
synthesis
the use of mutant enzyme P194A/I201A/F202V is feasible for application in the production of (S)-3-(4-chlorophenyl)-4-cyanobutanoic acid en route to (R)-baclofen
synthesis
Cereibacter sphaeroides LHS-305
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nitrilases are useful biocatalysts for the hydrolysis of nitriles in a mild and environmentally friendly manner assuring a clean process and specificity with high yield
-
synthesis
-
recombinant cells expressing the enzyme are promising catalysts for the synthesis of stable chiral quaternary carbon centers from ketones
-
synthesis
Rhodococcus sp. Novo SP361
-
enzyme can be used as a biocatalyst for the synthesis of a range of alpha-hydroxy carboxylic acids or amides from aldehydes in presence of cyanide, halting of the reaction at the amide intermediate by use of specific inhibitors is possible
-
synthesis
-
synthesis of beta-hydroxy carboxylic acids with high yield and optical purity by reudction of aromatic beta-ketonitriles with recombinant carbonyl reductase and nitrilase-catalyzed hydrolysis
-
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
-
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
-
synthesis
-
recombinant cells expressing the enzyme are promising catalysts for the synthesis of stable chiral quaternary carbon centers from ketones
-
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
-
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
-
synthesis
-
the high-level production of Arthrobacter aurescens CYC705 nitrilase will meet the need of industrial biosynthesis of iminodiacetic acid
-
synthesis
-
Pseudomonas aeruginosa RZ44 has the potential to be applied in the biotransformation of nitrile compounds
-
synthesis
-
a cascade reaction for the synthesis of optically pure (S)-beta-phenylalanine from benzoylacetonitrile was developed by coupling HpN with an omega-transaminase from Polaromonas sp. JS666 in toluene-water biphasic reaction system using beta-alanine as an amino donor. Various (S)-beta-amino acids can be produced from benzoylacetonitrile derivatives with moderate to high conversions (73-99%) and excellent enantioselectivity (above 99% enantiomeric exess). Great potential of this cascade reaction for the practical synthesis of (S)-beta-phenylalanine
-
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
-
synthesis
-
the broad range of substrate specificity, the high activity towards aliphatic, aromatic, and arylacetonitriles, and the highly stability, in terms of temperature, pH, and metal ions make the enzyme a promising biocatalyst for mild nitrile hydrolysis
-
synthesis
-
attractive as green, mild, and selective catalysts for setting stereogenic centers in fine-chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives
-
