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(6R,S)-5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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(6R,S)-methenyltetrahydrofolate + H2O
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10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
5,10-methenyl-tetrahydrofolate + H2O
10-formyltetrahydrofolate + H+
trifunctional enzyme exhibits synthetase, dehydrogenase and cyclohydrolase activities
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate + ?
cyclodehydrolase activity of MTHFD1
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5,10-methenyltetrahydrofolate + H2O
5-formyltetrahydrofolate
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5,10-methylenetetrahydrofolate + NADP+
5,10-methenyltetrahydrofolate + NADPH + H+
N5,N10-methenyltetrahydrofolate + H2O
N10-formyltetrahydrofolate
additional information
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(6R,S)-methenyltetrahydrofolate + H2O
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(6R,S)-methenyltetrahydrofolate + H2O
?
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r
10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
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r
10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
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10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
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10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
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10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
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10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
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10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
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10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
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low activity in the liver
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10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
Allium sp.
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing), EC 3.5.4.9, activity of the enzyme
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing), EC 3.5.4.9, activity of the enzyme
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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bifunctional enzyme exhibits dihydrogenase and cyclohydrolase activities
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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trifunctional enzyme exhibits synthetase, dehydrogenase and cyclohydrolase activities
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
the bifunctional enzyme also shows N5,N10-methylene-H4F dehydrogenase activity, EC 1.5.1.15
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
the bifunctional enzyme also shows N5,N10-methylene-H4F dehydrogenase activity, EC 1.5.1.15
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
Petroselinum sp.
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
Trifolium sp.
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
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?
5,10-methylenetetrahydrofolate + NADP+
5,10-methenyltetrahydrofolate + NADPH + H+
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methylenetetrahydrofolate dehydrogenase (NADP+), EC 1.5.1.5, activity of the enzyme
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5,10-methylenetetrahydrofolate + NADP+
5,10-methenyltetrahydrofolate + NADPH + H+
methylenetetrahydrofolate dehydrogenase (NADP+), EC 1.5.1.5, activity of the enzyme
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N5,N10-methenyltetrahydrofolate + H2O
N10-formyltetrahydrofolate
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N5,N10-methenyltetrahydrofolate + H2O
N10-formyltetrahydrofolate
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additional information
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bifunctional enzyme, channeling efficiency
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additional information
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bifunctional enzyme, channeling efficiency
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additional information
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the enzyme has a bifunctional DC domain that binds NADP+ and one folate molecule within a single catalytic cleft being part of a trifunctional enzyme, substrate channeling with high efficiency independent of NADP+ substrate binding efficiency
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additional information
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enzyme deficiency by G1958A polymorphism is involved in spontaneous cervical artery dissections
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additional information
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trifunctional folate enzyme
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additional information
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MTHFD1 is a trifunctional enzyme that interconverts tetrahydrofolate derivatives for nucleotide synthesis
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additional information
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the conversion of formyl- to methylenehydrofolate is rate-limited by the slow conversion by the cyclohydrolase of formyl- to methenyltetrahydrofolate
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additional information
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dehydrogenase and cyclohydrogenase activities are contained in the single bifunctional protein DHCH1
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additional information
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a bifuncitonal enzyme exhibiting N5,N10-methylenetetrahydrofolate dehydrogenase, EC 1.5.1.5, and N5,N10-methenyltetrahydrofolate cyclohydrolase activities
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additional information
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a bifuncitonal enzyme exhibiting N5,N10-methylenetetrahydrofolate dehydrogenase, EC 1.5.1.5, and N5,N10-methenyltetrahydrofolate cyclohydrolase activities
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additional information
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a bifuncitonal enzyme exhibiting N5,N10-methylenetetrahydrofolate dehydrogenase, EC 1.5.1.5, and N5,N10-methenyltetrahydrofolate cyclohydrolase activities
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additional information
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the determined amount of 5-formyltetrahydrofolate formation in the liver is low, possible role in one-carbon metabolism
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additional information
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the presence of cytoplasmic and mitochondrial isoforms of a trifunctional dehydrogenase-cyclohydrolase-synthetase support a model wherin the mitochondria can produce fromate which can be used by the cytoplasmic enzymes for the synthesis of purins and for methylation reactions
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additional information
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the presence of cytoplasmic and mitochondrial isoforms of a trifunctional dehydrogenase-cyclohydrolase-synthetase support a model wherin the mitochondria can produce fromate which can be used by the cytoplasmic enzymes for the synthesis of purins and for methylation reactions
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additional information
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the enzyme is a bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, cf. EC 1.5.1.5
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additional information
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the enzyme is a bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, cf. EC 1.5.1.5
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additional information
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tetrahydrofolate binding pocket structure analysis, residues 157-163 form a GXGXXXG motif and interact with the substrate, residues Asn157 and highly conserved Ser159 are important, overview
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additional information
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tetrahydrofolate binding pocket structure analysis, residues 157-163 form a GXGXXXG motif and interact with the substrate, residues Asn157 and highly conserved Ser159 are important, overview
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