3.5.4.9: methenyltetrahydrofolate cyclohydrolase

This is an abbreviated version!
For detailed information about methenyltetrahydrofolate cyclohydrolase, go to the full flat file.

Reaction

Synonyms

5,10-CH+-H4PteGlu cyclohydrolase, 5,10-CH+-THF cyclohydrolase, 5,10-CH=H4 folate synthetase, 5,10-methenyl-H4folate cyclohydrolase, 5,10-methenyl-THF cyclohydrolase, 5,10-methenyltetrahydrofolate cyclohydrolase, 5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase, 5,10-Methenyltetrahydrofolate synthetase, 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ADE3, bifunctional methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase, bifunctional N5,N10-methylene-H4F dehydrogenase/N5,N10-methenyl-H4F cyclohydrolase, CH+-THF cyclohydrolase, CHF4CH, Citrovorum factor cyclodehydrase, cyclohydrolase, dehydrogenasse-cyclohydrolase-synthetase, DHCH, DHCH 1, DHCH 2, DHCH1, FchA, FolD, formyl-methenyl-methylenetetrahydrofolate synthetase (combined), methenyl-H4F cyclohydrolase, methenyl-tetrahydrofolate cyclohydrolase, methenyl-THF cyclohydrolase, methenylH4F cyclohydrolase, methenyltetrahydrofolate cyclohydrolase, methenyltetrahydrofolate dehydrogenase/cyclohydrolase, methylene tetrahydrofolate dehydrogenase/cyclohydrolase, methylene-tetrahydrofolate dehydrogenase/cyclohydrolase, methyleneH4folate cyclohydrolase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase, MIS1, More, mosquito cyclohydrolase, MTHFD1, MTHFD2, MTHFD2L, MTHFDC, N5,N10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase, N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, N5,N10-methylenetetrahydrofolate dehydrogenase/N5,N10-methenyltetrahydrofolate cyclohydrolase, NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.9 methenyltetrahydrofolate cyclohydrolase

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Results	in table
7	Activating Compound
49967	AA Sequence
4	Application
1	CAS Registry Number
21	Cloned(Commentary)
6	Cofactor
8	Crystallization (Commentary)
486	Disease/ Diagnostics
2	Expression
8	General Information
3	General Stability
8	IC50 Value
35	Inhibitors
5	kcat/KM [mM/s]
5	Ki Value [mM]
64	KM Value [mM]
28	Localization
37	Molecular Weight [Da]
166	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
172	Organism
21	Pathway
86	PDB ID
15	pH Optimum
3	pH Range
36	Protein Variants
27	Purification (Commentary)
3	Reaction
5	Reaction Type
155	Reference
79	Source Tissue
101	Specific Activity [micromol/min/mg]
8	Storage Stability
185	Substrates and Products (Substrate)
30	Subunits
85	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
3	Temperature Stability [°C]
13	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.5.4.9 - methenyltetrahydrofolate cyclohydrolase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0025

2-[(2-chloro-6-fluorobenzyl)sulfanyl]-6-(trifluoromethyl)pyrimidin-4-ol

Pseudomonas aeruginosa

Q9I2U6

at pH 7.9 and 22°C

735050

0.0009

5-[(4-chlorophenyl)sulfonyl]-6-ethoxypyrimidine-2,4-diamine

Pseudomonas aeruginosa

Q9I2U6

at pH 7.9 and 22°C

735050

0.0038

6-benzyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

Pseudomonas aeruginosa

Q9I2U6

at pH 7.9 and 22°C

735050

0.013

di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano

Leishmania major

Q4Q9F9

with NPP1, pH 7.3, 37°C

720406

0.05

di-2'-deoxyadenosine 5',5''-P1,P5,alpha,beta-methylene-gamma,delta-methylene-tetraphosphate

Leishmania major

Q4Q9F9

with NPP1, pH 7.3, 37°C

720406

0.063

diadenosine 5',5''-P1,P5,alpha,beta-methylene-delta,epsilon-methylene-pentaphosphate-gamma-borano

Leishmania major

Q4Q9F9

with NPP1, pH 7.3, 37°C

720406

0.00003

LY374571

Pseudomonas aeruginosa

Q9I2U6

at pH 7.9 and 22°C

735050

0.033

P1,P4-bis(5'-adenosyl)-alpha,beta-gamma,delta-bismethylene-tetraphosphate

Leishmania major

Q4Q9F9

with NPP1, pH 7.3, 37°C

720406