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3.5.4.5: cytidine deaminase

This is an abbreviated version!
For detailed information about cytidine deaminase, go to the full flat file.

Word Map on EC 3.5.4.5

Reaction

2'-deoxycytidine
+
H2O
=
2'-deoxyuridine
 +
NH3

Synonyms

activation-induced cytidine deaminase, AICDA, canine hepatic cyd deaminase, CDA, CDABcald, CDABpsy, CDABsub, CDase, CDD, CR deaminase, cyd deaminase, Cytidine aminohydrolase, cytidine deaminase, cytidine/2'-deoxycytidine aminohydrolase, cytosine nucleoside deaminase, DCD, dCDA, deoxycytidine deaminase, EC 3.5.4.14, mammalian deminase, T-CDA, yeast cytidine deaminase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.5 cytidine deaminase

Temperature Range

Temperature Range on EC 3.5.4.5 - cytidine deaminase

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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
12 - 66
-
12°C: about 55% of maximal activity, 66°C: about 65% of maximal activity
15 - 65
-
mutant Y60G shows an unusual behavior with a mean of 75% activity for temperatures within this range and three peaks of maximum activity at about 30°C, 46°C, and 62°C
34 - 74
34°C: 45% of maximal activity, 74°C: 70% of maximal activity
37 - 75
-
60% of maximal activity at 75°C for the wild-type enzyme, 35% for mutant R68Q
40 - 62
-
heat treatment for 5 min at 50-60°C completely abolishes CMP and substrate inhibition
6 - 70
6°C: 45% of maximal activity, 70°C: 35% of maximal activity