3.5.4.5: cytidine deaminase
This is an abbreviated version!
For detailed information about cytidine deaminase, go to the full flat file.
Word Map on EC 3.5.4.5
-
3.5.4.5
-
hypermutation
-
immunoglobulin
-
deamination
-
ige
-
b-cells
-
lymphocyte
-
leukemia
-
lymphoma
-
diversification
-
class-switched
-
apobec3g
-
immunodeficiency
-
deaminases
-
uracil
-
gemcitabine
-
single-stranded
-
uridine
-
isotype
-
virion
-
arabinoside
-
cytarabine
-
retroviruses
-
ssdna
-
glycosylase
-
lymphomagenesis
-
deoxyuridine
-
cd40l
-
encapsidation
-
1-beta-d-arabinofuranosylcytosine
-
deoxycytidylate
-
c-to-u
-
blimp-1
-
nickase
-
mrna-editing
-
capecitabine
-
polypeptide-like
-
uracil-dna
-
microhomology
-
abasic
-
medicine
-
5-aza-cdr
-
drug development
-
protospacer
-
diagnostics
-
5'-deoxy-5-fluorouridine
-
5\'-dfur
-
plasmablast
-
retroelements
-
zebularine
-
ara-ctp
-
t-independent
-
anti-cd40
-
unmutated
- 3.5.4.5
-
hypermutation
- immunoglobulin
-
deamination
- ige
- b-cells
- lymphocyte
- leukemia
- lymphoma
-
diversification
-
class-switched
- apobec3g
- immunodeficiency
- deaminases
- uracil
- gemcitabine
-
single-stranded
- uridine
-
isotype
- virion
- arabinoside
- cytarabine
- retroviruses
- ssdna
- glycosylase
-
lymphomagenesis
- deoxyuridine
- cd40l
-
encapsidation
- 1-beta-d-arabinofuranosylcytosine
- deoxycytidylate
-
c-to-u
-
blimp-1
-
nickase
-
mrna-editing
- capecitabine
-
polypeptide-like
-
uracil-dna
-
microhomology
-
abasic
- medicine
-
5-aza-cdr
- drug development
-
protospacer
- diagnostics
- 5'-deoxy-5-fluorouridine
-
5\'-dfur
-
plasmablast
-
retroelements
- zebularine
- ara-ctp
-
t-independent
-
anti-cd40
-
unmutated
Reaction
Synonyms
activation-induced cytidine deaminase, AICDA, canine hepatic cyd deaminase, CDA, CDABcald, CDABpsy, CDABsub, CDase, CDD, CR deaminase, cyd deaminase, Cytidine aminohydrolase, cytidine deaminase, cytidine/2'-deoxycytidine aminohydrolase, cytosine nucleoside deaminase, DCD, dCDA, deoxycytidine deaminase, EC 3.5.4.14, mammalian deminase, T-CDA, yeast cytidine deaminase
ECTree
3.5.4.5 cytidine deaminaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.5.4.5 - cytidine deaminase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-amino-2',3'-dideoxycytidine + H2O
3'-amino-2',3'-dideoxyuridine + NH3
-
-
-
?
5'-chlorocyclocytidine + H2O
5'-chlorocyclouridine + NH3
-
i.e. cytosine, 1beta-D-arabinofuranosyl-2,2'-anhydro-, hydrochloride
-
-
?
gemcitabine + H2O
2'-deoxy-2',2'-difluorouridine
-
CDA is the major enzyme involved in gemcitabine inactivation, a cytotoxic drug commonly used in the treatment of pancreas and non-small cell lung cancer
-
-
?
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
?
-
-
-
-
?
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
?
-
FIAC poorly deminated
-
-
?
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O
?
-
-
-
-
?
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine + H2O
?
-
-
-
-
?
1-beta-D-arabinofuranosylcytosine + H2O
?
-
araC, most effective agent in therapy of acute myeloblastic leukemia
-
-
?
2',2'-difluorodeoxycytidine + H2O
2',2'-difluorodeoxyuridine + NH3
-
gemcitabine, antimetabolite of deoxycytidine, active against solid tumors and leukemic cell lines, deamination by the enzyme results in loss of pharmacologic activity
-
?
2',2'-difluorodeoxycytidine + H2O
2',2'-difluorodeoxyuridine + NH3
-
deamination of the deoxynucleoside analogue gemcitabine (dFdC) to difluorodeoxyuridine (dFdU), difluorodeoxyuridine used as radiosensitizer in gene therapy
-
-
?
2',3'-dideoxycytidine + H2O
2',3'-dideoxyuridinel + NH3
-
selective inhibitor of HIV reverse transcriptase
-
-
?
2',5'-anhydroarabinosylcytosine + H2O
2',5'-anhydroarabinosyluracil + NH3
-
-
-
-
?
2',5'-anhydroarabinosylcytosine + H2O
2',5'-anhydroarabinosyluracil + NH3
-
-
-
-
?
2'-deoxycytidine + H2O
2'-deoxyuridine + NH3
-
-
-
-
?
2'-deoxycytidine + H2O
2'-deoxyuridine + NH3
-
-
-
-
?
2'-deoxycytidine + H2O
2'-deoxyuridine + NH3
-
-
-
-
?
2'-deoxycytidine + H2O
2'-deoxyuridine + NH3
-
-
-
-
?
2'-deoxycytidine + H2O
2'-deoxyuridine + NH3
-
-
-
-
?
2'-fluoro-2'-deoxycytidine + H2O
2'-fluoro-2'-deoxyuridine + NH3
-
-
-
-
?
2'-fluoro-2'-deoxycytidine + H2O
2'-fluoro-2'-deoxyuridine + NH3
-
-
-
-
?
5'-fluoro-5'-deoxycytidine + H2O
5'-fluoro-5'-deoxyuridine + NH3
-
-
-
-
?
5'-fluoro-5'-deoxycytidine + H2O
5'-fluoro-5'-deoxyuridine + NH3
-
-
-
-
?
5'-fluoro-5'-deoxycytidine + H2O
5'-fluoro-5'-deoxyuridine + NH3
-
-
-
-
?
5'-methyl-2'-deoxycytidine + H2O
5'-methyl-2-deoxyuridine + NH3
-
-
-
-
?
5'-methyl-2'-deoxycytidine + H2O
5'-methyl-2-deoxyuridine + NH3
-
-
-
-
?
5'-methyl-2'-deoxycytidine + H2O
5'-methyl-2-deoxyuridine + NH3
-
-
-
-
?
5'-methyl-2'-deoxycytidine + H2O
5'-methyl-2-deoxyuridine + NH3
-
-
-
-
?
5'-methyl-2'-deoxycytidine + H2O
5'-methyl-2-deoxyuridine + NH3
-
-
-
-
?
5-aza-2'-deoxycytidine + H2O
5-aza-2'-deoxyuridine + NH3
-
5-AZA-CdR shows an antineoplastic action on 3T3 cells and V5 cells transduced with CR deaminase gene, pharmakokinetic analysis in mice, overview
-
-
?
5-azacytidine + H2O
5-azauridine + NH3
-
-
-
-
?
5-azacytidine + H2O
5-azauridine + NH3
-
-
-
-
?
5-azacytidine + H2O
5-azauridine + NH3
-
-
-
-
?
5-methylcytidine + H2O
5-methyluridine + NH3
-
-
-
-
?
cytarabine + H2O
uridine + NH3
180% of the activity with cytidine
-
-
?
cytarabine + H2O
uridine + NH3
180% of the activity with cytidine
-
-
?
cytidine + H2O
uridine + NH3
-
-
-
-
?
cytidine + H2O
uridine + NH3
-
-
209492, 209639, 209641, 209642, 209644, 209645, 209646, 209648, 209650, 209653, 209654, 209655, 209656, 209658, 209659, 209660, 209661, 209664, 209665, 209667, 209668, 209669
-
-
?
cytidine + H2O
uridine + NH3
-
-
209641, 209643, 209645, 209648, 209649, 209653, 209654, 209657, 209659, 209661, 209662, 209663, 209665, 209666, 209667, 209669, 670747, 685915, 686066, 689935, 699156, 700510
-
-
?
cytidine + H2O
uridine + NH3
-
cytidine deaminase is a key enzyme in the catabolism of cytosine nucleoside analogues, since their deamination results in a loss of their pharmacological activity
-
-
?
cytidine + H2O
uridine + NH3
-
development and implementation of the ONIOM-molecular dynamics method with cytidine deaminase as model enzyme for determination of activity and biochemical properties, product uridine is strongly perturbed by the thermal motion of the environment and dissociates easily from the active site, overview
-
-
?
cytidine + H2O
uridine + NH3
-
-
-
?
cytidine + H2O
uridine + NH3
-
-
209492, 209639, 209641, 209644, 209648, 209649, 209651, 209653, 209656, 209659, 209661, 209662, 209668, 689995
-
-
?
cytidine + H2O
uridine + NH3
cytidine is distinguished from uridine by its 4-NH2 group that acts as a hydrogen bond donor, the charge-neutralizing Arg68 of CDA exhibits two alternate conformations I and II, binding structure, overview
-
-
?
cytidine + H2O
uridine + NH3
-
-
209492, 209639, 209641, 209644, 209648, 209649, 209651, 209653, 209656, 209659, 209661, 209662, 209668
-
-
?
cytidine + H2O
uridine + NH3
-
-
-
-
?
cytidine + H2O
uridine + NH3
-
-
-
-
?
cytosine arabinoside + H2O
uridine arabinoside + NH3
-
-
-
-
?
cytosine arabinoside + H2O
uridine arabinoside + NH3
-
-
-
-
?
cytosine arabinoside + H2O
uridine arabinoside + NH3
-
-
-
-
?
cytosine arabinoside + H2O
uridine arabinoside + NH3
-
-
-
-
?
cytosine arabinoside + H2O
uridine arabinoside + NH3
-
-
-
-
?
deoxycytidine + H2O
deoxyuridine + NH3
-
-
-
-
?
deoxycytidine + H2O
deoxyuridine + NH3
-
-
-
-
?
deoxycytidine + H2O
deoxyuridine + NH3
-
-
-
-
?
deoxycytidine + H2O
deoxyuridine + NH3
-
-
-
-
?
deoxycytidine + H2O
deoxyuridine + NH3
-
-
-
-
?
N-4-monoacetylarabinosylcytosine
uracil arabinoside + carbamate
-
-
-
-
?
additional information
?
-
-
cytosine and cytosine nucleotides are no substrates
-
-
?
additional information
?
-
-
cytosine and cytidine nucleosides are not deaminated by this enzyme
-
-
?
additional information
?
-
-
cytosine and cytidine nucleosides are not deaminated by this enzyme
-
-
?
additional information
?
-
-
3-methylcytidine, cytosine and cyclocytidine are no substrates
-
-
?
additional information
?
-
-
3-methylcytidine, cytosine and cyclocytidine are no substrates
-
-
?
additional information
?
-
-
substrate specificity of wild-type and mutant enzymes, overview
-
-
?
additional information
?
-
-
cytidine deaminase plays an important role in the activation of the anticancer drug capesitabine in the human body
-
-
?
additional information
?
-
-
cyclocytidine, N-4-acetylarabinosylcytosine, tetraacetylarabinosylcytosine, N4-behenoylarabinosylcytosine and tri-O-acetylarabinosylcytosine are no substrates
-
-
?
additional information
?
-
-
cytosine, 5-methylcytosine, 6-methylaminopurine, CMP, dCMP, CDP, dCDP, CTP and dCTP are no substrates
-
-
?
additional information
?
-
active site and substrate binding structure, overview
-
-
?
additional information
?
-
-
active site and substrate binding structure, overview
-
-
?
additional information
?
-
-
cytosine, 5-methylcytosine, 6-methylaminopurine, CMP, dCMP, CDP, dCDP, CTP and dCTP are no substrates
-
-
?
additional information
?
-
-
cyclocytidine, N-4-acetylarabinosylcytosine, tetraacetylarabinosylcytosine, N4-behenoylarabinosylcytosine and tri-O-acetylarabinosylcytosine are no substrates
-
-
?
additional information
?
-
-
cytosine and cytosine nucleotides are no substrates
-
-
?
