3.5.4.3: guanine deaminase

This is an abbreviated version!
For detailed information about guanine deaminase, go to the full flat file.

Reaction

Synonyms

Agdap, cypin, cytosolic PSD-95 interactor, E. coli guanine deaminase, GAH, GDA, GDEase, GUA, guaD, guanase, guanine aminase, Guanine aminohydrolase, guanine deaminase, GUD1, human guanine deaminase, KLLAOD9492, More, NE0047, p51-nedasin, YgfP

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.3 guanine deaminase

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Results	in table
11	Activating Compound
13922	AA Sequence
13	Application
1	CAS Registry Number
12	Cloned(Commentary)
5	Crystallization (Commentary)
274	Disease/ Diagnostics
3	Expression
13	General Information
4	General Stability
141	Inhibitors
13	kcat/KM [mM/s]
26	Ki Value [mM]
106	KM Value [mM]
14	Localization
26	Metals/Ions
122	Molecular Weight [Da]
72	Natural Substrates/ Products (Substrates)
340	Organism
9	Pathway
21	PDB ID
59	pH Optimum
7	pH Range
2	pH Stability
2	pI Value
18	Protein Variants
32	Purification (Commentary)
3	Reaction
2	Reaction Type
98	Reference
151	Source Tissue
32	Specific Activity [micromol/min/mg]
13	Storage Stability
172	Substrates and Products (Substrate)
61	Subunits
48	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Range [°C]
26	Temperature Stability [°C]
14	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 3.5.4.3 - guanine deaminase

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5.5

Rattus norvegicus

-

8-azaguanine as substrate

209596

5.9

Oryctolagus cuniculus

-

liver enzyme

209586

6

2 entries

6.5

Blastobotrys adeninivorans

-

the native enzyme shows optimal pH values of 6.5 and 8.0 while the recombinant enzyme has a single pH optimum at pH 6.5

734510

6.8

2 entries

7

2 entries

7 - 7.5

2 entries

7 - 8

Mus musculus

-

-

209596

7.4

4 entries

7.4 - 9.4

Rattus norvegicus

-

-

209589

7.5

2 entries

7.5 - 9.5

4 entries

7.7

Oryctolagus cuniculus

-

-

209587, 209595

8

5 entries

8 - 8.5

Oryctolagus cuniculus

-

-

209587

8.5

4 entries

8.6

Oryctolagus cuniculus

-

-

209585

9

3 entries

6

Homo sapiens

-

8-azaguanine as substrate

209586

6

Oryctolagus cuniculus

-

8-azaguanine as substrate

209586, 209592, 209595

6.8

Oryctolagus cuniculus

-

-

209585, 209586, 209587

6.8

Oryctolagus cuniculus

-

pH optimum is independent of the buffer system

209592, 209595

7

Homo sapiens

Q9Y2T3

recombinant protein, expressed in mice DH5-alpha cells, Km remains constant between pH 6.5 and pH 7.5

209602

7

Kluyveromyces lactis

-

-

753649

7 - 7.5

Camellia sinensis

-

double peaks of optimum activity, second optimum at pH 8.5

209539

7 - 7.5

Rattus norvegicus

-

double peaks of optimum activity, second optimum at pH 8.5

209539

7.4

Homo sapiens

-

isoenzyme A

209590

7.4

Klebsiella pneumoniae

-

assay at

719723

7.4

Oryctolagus cuniculus

-

assay at

667985

7.4

Rattus norvegicus

-

assay at

689944

7.5

Drosophila melanogaster

-

-

712380

7.5

Rattus norvegicus

-

-

209588

7.5 - 9.5

Homo sapiens

-

-

209584

7.5 - 9.5

Homo sapiens

-

beyond pH 9.5 activity decreases abruptly

209585

7.5 - 9.5

Oryctolagus cuniculus

-

-

209584, 209585

7.5 - 9.5

Rattus norvegicus

-

-

209584, 209585

8

Blastobotrys adeninivorans

-

the native enzyme shows optimal pH values of 6.5 and 8.0

734510

8

Homo sapiens

-

-

209585, 209586, 209587, 209594

8

Mus musculus

-

-

209596

8

Oryctolagus cuniculus

-

-

209585, 209586, 209587, 209591, 209594, 209595

8

Rattus norvegicus

-

-

209585, 209586, 209594, 209595, 209596

8.5

Camellia sinensis

-

double peaks of optimum activity, second optimum between pH 7 and pH 7.5

209539

8.5

Oryctolagus cuniculus

-

-

209585

8.5

Rattus norvegicus

-

-

209585

8.5

Rattus norvegicus

-

double peaks of optimum activity, second optimum between pH 7 and pH 7.5

209539

9

Homo sapiens

-

-

209584, 209585

9

Homo sapiens

-

isoenzyme B

209590

9

Sus sp.

-

-

209584