3.5.4.3: guanine deaminase

This is an abbreviated version!
For detailed information about guanine deaminase, go to the full flat file.

Reaction

Synonyms

Agdap, cypin, cytosolic PSD-95 interactor, E. coli guanine deaminase, GAH, GDA, GDEase, GUA, guaD, guanase, guanine aminase, Guanine aminohydrolase, guanine deaminase, GUD1, human guanine deaminase, KLLAOD9492, More, NE0047, p51-nedasin, YgfP

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.3 guanine deaminase

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Results	in table
11	Activating Compound
13922	AA Sequence
13	Application
1	CAS Registry Number
12	Cloned(Commentary)
5	Crystallization (Commentary)
274	Disease/ Diagnostics
3	Expression
13	General Information
4	General Stability
141	Inhibitors
13	kcat/KM [mM/s]
26	Ki Value [mM]
106	KM Value [mM]
14	Localization
26	Metals/Ions
122	Molecular Weight [Da]
72	Natural Substrates/ Products (Substrates)
340	Organism
9	Pathway
21	PDB ID
59	pH Optimum
7	pH Range
2	pH Stability
2	pI Value
18	Protein Variants
32	Purification (Commentary)
3	Reaction
2	Reaction Type
98	Reference
151	Source Tissue
32	Specific Activity [micromol/min/mg]
13	Storage Stability
172	Substrates and Products (Substrate)
61	Subunits
48	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Range [°C]
26	Temperature Stability [°C]
14	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.5.4.3 - guanine deaminase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ammeline + H2O

?

Nitrosomonas europaea

Q82Y41

-

733339

-

-

?

guanine + H2O

xanthine + NH3

29 entries

guanine + H2O

xanthine + NH3

Bacillus subtilis

-

-

688614

-

-

?

guanine + H2O

xanthine + NH3

Blastobotrys adeninivorans

-

100% activity

734510

-

-

r

guanine + H2O

xanthine + NH3

Blastobotrys adeninivorans LS3

-

100% activity

734510

-

-

r

guanine + H2O

xanthine + NH3

Bos taurus

-

-

209586, 209587

-

-

?

guanine + H2O

xanthine + NH3

Camellia sinensis

-

-

209539

-

-

?

guanine + H2O

xanthine + NH3

Cavia porcellus

-

-

209587

-

-

?

guanine + H2O

xanthine + NH3

Clostridium sp.

-

-

209539, 209588, 209597

-

-

?

guanine + H2O

xanthine + NH3

Escherichia coli

-

-

209603

-

-

?

guanine + H2O

xanthine + NH3

Homo sapiens

-

-

209584, 209586, 209587, 209588, 209594, 209598, 209600, 209601

-

-

?

guanine + H2O

xanthine + NH3

Homo sapiens

-

-

209585, 209590

-

-

ir

guanine + H2O

xanthine + NH3

Homo sapiens

Q9Y2T3

-

209603

-

-

?

guanine + H2O

xanthine + NH3

Homo sapiens

Q9Y2T3

-

209602

-

-

ir

guanine + H2O

xanthine + NH3

Mus musculus

-

-

209588, 209593, 209596, 209598

-

-

?

guanine + H2O

xanthine + NH3

Mus musculus

-

-

209590, 209602

-

-

ir

guanine + H2O

xanthine + NH3

Nicotiana tabacum

-

-

209539

-

-

?

guanine + H2O

xanthine + NH3

Nitrosomonas europaea

Q82Y41

-

733339

-

-

?

guanine + H2O

xanthine + NH3

Ophiodon elongatus

-

-

209588, 209594

-

-

?

guanine + H2O

xanthine + NH3

Oryctolagus cuniculus

-

-

209584, 209586, 209587, 209591, 209592, 209593, 209594, 209595, 209601, 667985, 733480, 733496

-

-

?

guanine + H2O

xanthine + NH3

Oryctolagus cuniculus

-

-

209585

-

-

ir

guanine + H2O

xanthine + NH3

Ovis ammon

-

-

209587, 209593

-

-

?

guanine + H2O

xanthine + NH3

Platyrrhini

-

-

209593

-

-

?

guanine + H2O

xanthine + NH3

Pseudarthrobacter oxydans

-

nucleotide metabolism

697984

-

-

?

guanine + H2O

xanthine + NH3

Rattus norvegicus

-

-

209539, 209584, 209586, 209588, 209589, 209593, 209594, 209595, 209596, 209598

-

-

?

guanine + H2O

xanthine + NH3

Rattus norvegicus

-

-

209585, 209590

-

-

ir

guanine + H2O

xanthine + NH3

Rattus norvegicus

-

the enzyme plays a central role in neuronal development, and an active role in regulating dendrite branching in hippocampal neurons, cypin-promoted increases in dendrite number are dependent on its zinc-dependent guanine deaminase activity, overview

689944

-

-

?

guanine + H2O

xanthine + NH3

Rattus norvegicus Sprague Dawley

-

-

209588

-

-

?

guanine + H2O

xanthine + NH3

Rattus norvegicus Wistar

-

-

209589

-

-

?

guanine + H2O

xanthine + NH3

Sus sp.

-

-

209584, 209586, 209587, 209589, 209593

-

-

?

guanine + H2O

xanthine + NH3

Sus sp.

-

-

209602

-

-

ir