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3.5.4.2: adenine deaminase

This is an abbreviated version!
For detailed information about adenine deaminase, go to the full flat file.

Word Map on EC 3.5.4.2

Reaction

adenine
+
H2O
=
hypoxanthine
 +
NH3

Synonyms

aadA, AAH, Aah1p, AAur1117, ADA, ADase, ADE, adenase, adenine aminase, adenine deaminase, KLLAOE2317, MJ1459, NadA, Pa0148, Sgx9403e, Sgx9403g

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.2 adenine deaminase

Inhibitors

Inhibitors on EC 3.5.4.2 - adenine deaminase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
2'-deoxycoformycin
-
-
3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one
-
an inhibition of ADA activity using 100 nM is observed, an increase in cellular viability is shown when 0.03 mM is used
4-Aminopyrazolo[3,4-d]pyrimidine
-
-
6-Chloropurine
-
-
6-Dimethylaminopurine
-
-
6-Methylaminopurine
-
-
coformycin
Cu2+
64% residual activity at 1 mM
Deoxycoformycin
Fe2+
7% residual activity at 1 mM
hypoxanthine
-
competitive, Ki 4 mM
Mercuric acetate
-
-
Mercuric chloride
-
-
Monoiodoacetic acid
-
-
Ni2+
48% residual activity at 1 mM
p-chloromercuribenzoate
-
-
purine
additional information
-