3.5.4.2: adenine deaminase

This is an abbreviated version!
For detailed information about adenine deaminase, go to the full flat file.

Reaction

Synonyms

aadA, AAH, Aah1p, AAur1117, ADA, ADase, ADE, adenase, adenine aminase, adenine deaminase, KLLAOE2317, MJ1459, NadA, Pa0148, Sgx9403e, Sgx9403g

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.2 adenine deaminase

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Results	in table
23326	AA Sequence
2	Application
1	CAS Registry Number
11	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
23	Disease/ Diagnostics
1	Expression
1	General Information
4	General Stability
43	Inhibitors
52	kcat/KM [mM/s]
3	Ki Value [mM]
68	KM Value [mM]
9	Localization
12	Metals/Ions
13	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
69	Organism
5	Pathway
7	PDB ID
23	pH Optimum
5	pH Range
3	pH Stability
30	Protein Variants
10	Purification (Commentary)
1	Reaction
1	Reaction Type
41	Reference
17	Specific Activity [micromol/min/mg]
8	Storage Stability
126	Substrates and Products (Substrate)
9	Subunits
23	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
2	Temperature Range [°C]
13	Temperature Stability [°C]
54	Turnover Number [1/s]

General Information

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General Information on EC 3.5.4.2 - adenine deaminase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Leishmania donovani

-

deletion of the AAH locus in intact parasites establishes that AAH is not an essential gene and that -/-aah cells are capable of salvaging the same range of purine nucleobases and nucleosides as wild type Leishmania donovani. The aah null mutant is able to infect murine macrophages in vitro and in mice, although the parasite loads in both model systems are modestly reduced compared with wild type infections

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