3.5.4.10: IMP cyclohydrolase

This is an abbreviated version!
For detailed information about IMP cyclohydrolase, go to the full flat file.

Reaction

Synonyms

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase/IMP cyclohydrolase, AF1811, AICAR tranformylase/IMP cyclohydrolase, AICAR transformylase/IMP cyclohydrolase, AICAR transformylase/inosine 5'-monophosphate cyclohydrolase, AICAR-FT/IMP-CHase, AICAR-transformylase/IMP cyclohydrolase, ATIC, atic-1, IMP synthetase, IMPCH, IMPCHase, inosinate cyclohydrolase, inosine 5'-monophosphate cyclohydrolase, inosine monophosphate cyclohydrolase, inosinicase, ITGA2, MjPurO, MthPurO, PurH, PurH2, PurH2-type IMP cyclohydrolase, PurO, PurO-type IMP cyclohydrolase, TK0430

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.10 IMP cyclohydrolase

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Results	in table
2	Activating Compound
37909	AA Sequence
3	Application
1	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
397	Disease/ Diagnostics
1	Expression
12	General Information
4	IC50 Value
26	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
26	KM Value [mM]
1	Metals/Ions
13	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
40	Organism
8	Pathway
58	PDB ID
12	pH Optimum
2	pH Range
3	pH Stability
1	pI Value
1	Posttranslational Modification
30	Protein Variants
16	Purification (Commentary)
6	Reaction
1	Reaction Type
39	Reference
19	Source Tissue
10	Specific Activity [micromol/min/mg]
2	Storage Stability
45	Substrates and Products (Substrate)
19	Subunits
44	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
23	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.5.4.10 - IMP cyclohydrolase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

12 entries

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

?

9 entries

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

IMP + H2O

8 entries

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide + H2O

?

Homo sapiens

P31939

catalyzation of the final two steps of de novo purine biosynthesis pathway

696946

-

-

?

5-formamidoimidazole-4-carboxamide

hypoxanthine + H2O

2 entries

5-formaminoimidazole-4-carboxamide ribonucleotide

IMP + H2O

2 entries

trans-alpha,beta-diformamido-beta-(5'-phosphoribosylamino)acrylamide

IMP + H2O

2 entries

additional information

?

-

3 entries

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Archaeoglobus fulgidus

O28464

-

758185

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Archaeoglobus fulgidus

O28464

the enzyme catalyze the final step of de novo purine biosynthesis

758185

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Archaeoglobus fulgidus ATCC 49558

O28464

-

758185

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Archaeoglobus fulgidus ATCC 49558

O28464

the enzyme catalyze the final step of de novo purine biosynthesis

758185

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Escherichia coli

P15639

-

757625

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Escherichia coli K12

P15639

-

757625

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Staphylococcus lugdunensis

A0A133Q8U5

-

756701

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Staphylococcus lugdunensis

A0A133Q8U5

the two activities of the bifunctional AICAR transformylase/IMP cyclohydrolase reside on separate domains

756701

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Thermococcus kodakarensis

Q5JD29

-

758185

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Thermococcus kodakarensis

Q5JD29

the enzyme catalyze the final step of de novo purine biosynthesis

758185

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Thermococcus kodakarensis ATCC BAA-918

Q5JD29

-

758185

-

-

?

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

IMP + H2O

Thermococcus kodakarensis ATCC BAA-918

Q5JD29

the enzyme catalyze the final step of de novo purine biosynthesis

758185

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

?

Bacillus subtilis

-

de novo purine synthesis step 10

1259

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

?

Escherichia coli

-

de novo purine synthesis step 10

172168, 172169

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

?

Gallus gallus

-

de novo purine synthesis step 10

172158, 172160, 172166, 485747

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

?

Homo sapiens

-

de novo purine synthesis step 10

172161, 172162, 172165

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

?

Homo sapiens

P31939

de novo purine synthesis step 10

172163

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

?

Mus musculus

-

de novo purine synthesis step 10

172157

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

?

Rattus norvegicus

-

de novo purine synthesis step 10

172158, 172164

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

?

Salmonella enterica subsp. enterica serovar Typhimurium

-

de novo purine synthesis step 10

172156

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

?

Sus scrofa

-

de novo purine synthesis step 10

172155

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

IMP + H2O

Gallus gallus

-

-

172158

-

172158

ir

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

IMP + H2O

Gallus gallus

-

-

172160

-

172160

ir

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

IMP + H2O

Homo sapiens

-

-

485758

-

485758

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

IMP + H2O

Homo sapiens

-

-

658026

-

-

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

IMP + H2O

Homo sapiens

-

-

485759

-

485759

ir

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

IMP + H2O

Homo sapiens

P31939

-

172163

-

172163

ir

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

IMP + H2O

Methanocaldococcus jannaschii

Q58043

-

651694

-

651694

?

5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide

IMP + H2O

Sus scrofa

-

-

172155

-

172155

ir

5-formamidoimidazole-4-carboxamide

hypoxanthine + H2O

Homo sapiens

-

-

172161

-

172161

ir

5-formamidoimidazole-4-carboxamide

hypoxanthine + H2O

Homo sapiens

P31939

-

172163

-

-

ir

5-formaminoimidazole-4-carboxamide ribonucleotide

IMP + H2O

Methanothermobacter thermautotrophicus

O27089

the enzyme catalyzes the cyclization of 5-formaminoimidazole-4-carboxamide ribonucleotide, FAICAR, to IMP in the final step of de novo purine biosynthesis

685152

-

-

?

5-formaminoimidazole-4-carboxamide ribonucleotide

IMP + H2O

Thermotoga maritima

Q9X0X6

the IMPCH domain catalyzes the intramolecular cyclization of 5-formyl-AICAR, FAICAR, to IMP

689976

-

-

?

trans-alpha,beta-diformamido-beta-(5'-phosphoribosylamino)acrylamide

IMP + H2O

Gallus gallus

-

-

172158

-

172158

ir

trans-alpha,beta-diformamido-beta-(5'-phosphoribosylamino)acrylamide

IMP + H2O

Rattus norvegicus

-

-

172158

-

172158

ir

additional information

?

-

Gallus gallus

P31335

bifunctional enzyme aminoimidazole-comprising the 4-carboxamide ribonucleotide transformylase, AICAR or Tfase, residues 200-593 and the IMPCH, ATIC, activities and catalyzes the final step in the de novo purine biosynthesis pathway that produces IMP, overview

687546

-

-

?

additional information

?

-

Thermotoga maritima

Q9X0X6

the TM1249 gene or gene purH of Thermotoga maritima encodes a bifunctional enzyme with 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, AICAR Tfase, EC 2.1.2.3, and inosine 5'-monophosphate cyclohydrolase, IMPCH, EC 3.5.4.10, activities. These activities represent the final two steps of the de novo purine biosynthesis pathway, overview

689976

-

-

?

additional information

?

-

Thermotoga maritima

-

the TM1249 gene or gene purH of Thermotoga maritima encodes a bifunctional enzyme with 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, AICAR Tfase, EC 2.1.2.3, and inosine 5'-monophosphate cyclohydrolase, IMPCH, EC 3.5.4.10, activities. These activities represent the final two steps of the de novo purine biosynthesis pathway, overview

689976

-

-

?