3.5.4.10: IMP cyclohydrolase
This is an abbreviated version!
For detailed information about IMP cyclohydrolase, go to the full flat file.
Word Map on EC 3.5.4.10
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3.5.4.10
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integrins
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itgav
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ecm-receptor
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faicar
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alpha2beta1
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tfase
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medicine
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drug development
- 3.5.4.10
- integrins
-
itgav
-
ecm-receptor
-
faicar
- alpha2beta1
-
tfase
- medicine
- drug development
Reaction
Synonyms
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase/IMP cyclohydrolase, AF1811, AICAR tranformylase/IMP cyclohydrolase, AICAR transformylase/IMP cyclohydrolase, AICAR transformylase/inosine 5'-monophosphate cyclohydrolase, AICAR-FT/IMP-CHase, AICAR-transformylase/IMP cyclohydrolase, ATIC, atic-1, IMP synthetase, IMPCH, IMPCHase, inosinate cyclohydrolase, inosine 5'-monophosphate cyclohydrolase, inosine monophosphate cyclohydrolase, inosinicase, ITGA2, MjPurO, MthPurO, PurH, PurH2, PurH2-type IMP cyclohydrolase, PurO, PurO-type IMP cyclohydrolase, TK0430
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Reference on EC 3.5.4.10 - IMP cyclohydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ebbole, D.J.; Zalkin, H.
Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis
J. Biol. Chem.
262
8274-8287
1987
Bacillus subtilis
Flaks, J.G.; Erwin, M.J.; Buchanan, J.M.
Biosynthesis of the purines: XVIII. 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase and inosinicase
J. Biol. Chem.
229
603-612
1957
Sus scrofa
Gots, S.J.; Dalal, F.R.; Shumas, S.R.
Genetic separation of the inosinic acid cyclohydrolase-transformylase complex of Salmonella typhimurium
J. Bacteriol.
99
441-449
1969
Salmonella enterica subsp. enterica serovar Typhimurium
Geiger, R.; Guglielmi, H.
[IMP-cyclohydrolase/transformylase from Ehrlich-ascites carcinoma
Hoppe-Seyler's Z. Physiol. Chem.
356
819-825
1975
Mus musculus
Baggott, J.E.; Krumdieck, C.L.
trans-alpha, beta-Diformamido-beta-(5-phosphoribosylamino)acrylamide: a possible new intermediate in de novo purine biosynthesis
Biochemistry
18
3501-3506
1979
Gallus gallus, Rattus norvegicus
Ni, L.; Guan, K.; Zalkin, H.; Dixon, J.D.
De novo purine biosynthesis: cloning, sequencing and expression of a chicken PurH cDNA encoding 5-aminoimidazole-4-carboxamide-ribinucleotide transformylase-IMP cyclohydrolase
Gene
106
197-205
1981
Gallus gallus
Szabados, E.; Hindmarsh, E.J.; Phillips, L.; Duggleby, R.G.; Christopherson, R.I.
5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence and inhibitors
Biochemistry
33
14237-14245
1994
Homo sapiens
Christopherson, R.I.; Williams, N.K.; Schoettle, S.L.; Szabados, E.; Hambley, T.W.; Manthey, M.K.
Inhibitors of dihydroorotase, amidophosphoribosyltransferase and IMP cyclohydrolase as potential drugs
Biochem. Soc. Trans.
23
888-893
1995
Homo sapiens
Rayl, E.A.; Moroson, B.A.; Beardsley, G.P.
The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping
J. Biol. Chem.
271
2225-2233
1996
Homo sapiens (P31939), Homo sapiens
Akira, T.; Komatsu, M.; Nango, R.; Tomooka, A.; Konaka, K.; Yamauchi, M.; Kitamura, Y.; Nomura, S.; Tsukamoto, I.
Molecular cloning and expression of a rat cDNA encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene
197
289-293
1997
Rattus norvegicus
Szabados, E.; Manthey, M.K.; Wilson, P.K.; Christopherson, R.I.
Inosine-5'-monophosphate analogues as inhibitors of human IMPcyclohydrolase and cellular growth
Biochem. Mol. Biol. Int.
44
617-623
1998
Homo sapiens
Caperelli, C.A.; Benkovic, P.A.; Chettur, G.; Benkovic, S.J
Purification of a complex catalizing folate cofactor synthesis and transformylation in de novo purine biosynthesis
J. Biol. Chem.
255
1885-1890
1980
Gallus gallus
Aiba, A.; Mizobuchi, K.
Nucleotide sequence analysis of genes purH and purD involved in the de novo purine nucleotide biosynthesis of Escherichia coli
J. Biol. Chem.
264
21239-21246
1989
Escherichia coli
Flannigan, K.A.; Hennigan, S.H.; Vogelbacker, H.H.; Gots, J.S.; Smith, J.M.
Purine biosynthesis in Escherichia coli K12: structure and DNA sequence studies of the purHD locus
Mol. Microbiol.
4
381-392
1990
Escherichia coli
Mueller, W.T.; Benkovic, S.J.
On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver
Biochemistry
20
337-344
1981
Gallus gallus
Vergis, J.M.; Bulock, K.G.; Fleming, K.G.; Beardsley, G.P.
Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity
J. Biol. Chem.
276
7727-7733
2001
Homo sapiens
Bulock, K.G.; Beardsley, G.P.; Anderson, K.S.
The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase): A surprising lack of substrate channeling
J. Biol. Chem.
277
22168-22174
2002
Homo sapiens
Wolan, D.W.; Cheong, C.G.; Greasley, S.E.; Wilson, I.A.
Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor
Biochemistry
43
1171-1183
2004
Homo sapiens (P31939), Homo sapiens
Graupner, M.; Xu, H.; White, R.H.
New class of IMP cyclohydrolases in Methanococcus jannaschii
J. Bacteriol.
184
1471-1473
2002
Methanocaldococcus jannaschii (Q58043), Methanocaldococcus jannaschii
Cheong, C.G.; Wolan, D.W.; Greasley, S.E.; Horton, P.A.; Beardsley, G.P.; Wilson, I.A.
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates
J. Biol. Chem.
279
18034-18045
2004
Homo sapiens (P31939), Homo sapiens
Vergis, J.M.; Beardsley, G.P.
Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase
Biochemistry
43
1184-1192
2004
Homo sapiens
Marie, S.; Heron, B.; Bitoun, P.; Timmerman, T.; Van Den Berghe, G.; Vincent, M.F.
AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC
Am. J. Hum. Genet.
74
1276-1281
2004
Homo sapiens (P31939), Homo sapiens
Yocum, G.D.
Environmental regulation of the purine synthesis enzyme purH transcript during adult diapause in Leptinotarsa decemlineata (Coleoptera: Chrysomelidae)
Eur. J. Entomol.
101
199-203
2004
Leptinotarsa decemlineata
-
Penuelas, S.; Noe, V.; Ciudad, C.J.
Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells
FEBS J.
272
696-710
2005
Homo sapiens (P31939), Homo sapiens
Kang, Y.N.; Tran, A.; White, R.H.; Ealick, S.E.
A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase
Biochemistry
46
5050-5062
2007
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus (O27089)
Xu, L.; Chong, Y.; Hwang, I.; DOnofrio, A.; Amore, K.; Beardsley, G.P.; Li, C.; Olson, A.J.; Boger, D.L.; Wilson, I.A.
Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
J. Biol. Chem.
282
13033-13046
2007
Gallus gallus (P31335)
Axelrod, H.L.; McMullan, D.; Krishna, S.S.; Miller, M.D.; Elsliger, M.; Abdubek, P.; Ambing, E.; Astakhova, T.; Carlton, D.; Chiu, H.; Clayton, T.; Duan, L.; Feuerhelm, J.; Grzechnik, S.K.; Hale, J.; Han, G.W.; Haugen, J.; Jaroszewski, L.; Jin, K.K.; Klock, H.E.; Knuth, M.W.; Koesema, E.; Morse, A.T.; Nigoghossian, E.; Okach, L.; Oommachen, S.; Paulsen, J.; Quijano, K.; Reyes, R.; Rife, C.L.; van den Bedem, H.; Weekes, D.; White, A.; Wolf, G.; Xu, Q.; Hodgson, K.O.; Wooley, J.; Deacon. A.M.; Godzik, A.; Lesley, S.A.; Wilson, I.A.
Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 ANG. resolution
Proteins Struct. Funct. Bioinform.
71
1042-1049
2008
Thermotoga maritima (Q9X0X6), Thermotoga maritima
Boccalatte, F.E.; Voena, C.; Riganti, C.; Bosia, A.; DAmico, L.; Riera, L.; Cheng, M.; Ruggeri, B.; Jensen, O.N.; Goss, V.L.; Lee, K.; Nardone, J.; Rush, J.; Polakiewicz, R.D.; Comb, M.J.; Chiarle, R.; Inghirami, G.
The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL
Blood
113
2776-2790
2009
Homo sapiens (P31939)
Chen, X.; Zhao, J.; Xu, X.; Zeng, R.
Screening and cloning of IMP cyclohydrolase from a metagenomic cosmid library of a deep-sea sediment sample
Chin. J. Appl. Environ. Biol.
17
855-859
2011
Homo sapiens
-
Verma, P.; Kar, B.; Varshney, R.; Roy, P.; Sharma, A.
Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis
FEBS J.
284
4233-4261
2017
Staphylococcus lugdunensis (A0A133Q8U5), Staphylococcus lugdunensis
Riedinger, C.; Mendler, M.; Schlotterer, A.; Fleming, T.; Okun, J.; Hammes, H.P.; Herzig, S.; Nawroth, P.P.
High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans
J. Biol. Chem.
293
4845-4859
2018
Caenorhabditis elegans (Q95QQ4)
Sah, S.; Shah, R.; Govindan, A.; Varada, R.; Rex, K.; Varshney, U.
Utilisation of 10-formyldihydrofolate as substrate by dihydrofolate reductase (DHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) tranformylase/IMP cyclohydrolase (PurH) in Escherichia coli
Microbiology
164
982-991
2018
Escherichia coli (P15639), Escherichia coli K12 (P15639)
Boutchueng-Djidjou, M.; Collard-Simard, G.; Fortier, S.; Hebert, S.; Kelly, I.; Landry, C.; Faure, R.
The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network
Mol. Cell. Proteomics
14
1079-1092
2015
Rattus norvegicus (O35567)
Hunter, C.; Plymale, N.; Smee, K.; Sarisky, C.
Experimental characterization of two archaeal inosine 5'-monophosphate cyclohydrolases
PLoS ONE
14
e0223983
2019
Archaeoglobus fulgidus (O28464), Thermococcus kodakarensis (Q5JD29), Archaeoglobus fulgidus ATCC 49558 (O28464), Thermococcus kodakarensis ATCC BAA-918 (Q5JD29)
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