3.5.4.10: IMP cyclohydrolase

This is an abbreviated version!
For detailed information about IMP cyclohydrolase, go to the full flat file.

Word Map on EC 3.5.4.10

Reaction

IMP
+
H2O
=
5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Synonyms

inosinicase, inosinate cyclohydrolase, IMPCHase, inosine monophosphate cyclohydrolase, ATIC, IMP synthetase, IMPCH, PurH, inosine 5'-monophosphate cyclohydrolase, MthPurO, PurO, MjPurO, AICAR transformylase/inosine 5'-monophosphate cyclohydrolase, AICAR-FT/IMP-CHase, ITGA2, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase/IMP cyclohydrolase, AICAR tranformylase/IMP cyclohydrolase, AICAR-transformylase/IMP cyclohydrolase, atic-1, AICAR transformylase/IMP cyclohydrolase, TK0430, PurO-type IMP cyclohydrolase, PurH2, AF1811, PurH2-type IMP cyclohydrolase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.10 IMP cyclohydrolase

Application

Application on EC 3.5.4.10 - IMP cyclohydrolase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
medicine
determination of differentially expressed genes in HT-29 cells, both after short treatment with methotrexate and after the resistance to methotrexate has been established. Enzyme as well as survivin and inosine monophosphate dehydrogenase type II are upregulated