3.5.3.6: arginine deiminase
This is an abbreviated version!
For detailed information about arginine deiminase, go to the full flat file.
Word Map on EC 3.5.3.6
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3.5.3.6
-
ornithine
-
streptococcus
-
argininosuccinate
-
pegylated
-
levan
-
king
-
carbamate
-
reisolated
-
mycoplasma
-
water-soaked
-
syringae
-
greenhouse
-
urease
-
arginase
-
adi-peg20
-
lopat
-
dna-dna
-
melibiose
-
pathovars
-
d-sorbitol
-
midi
-
gordonii
-
l-citrulline
-
voges-proskauer
-
newark
-
l-rhamnose
-
symptomless
-
aesculin
-
d-mannitol
-
rep-pcr
-
ncppb
-
surface-sterilized
-
lecithinase
-
glistening
-
cichorii
-
amygdalin
-
arginine-dependent
-
supragingival
-
deimination
-
phytopathology
-
sanguinis
-
non-spore-forming
-
salicin
-
malolactic
-
maculicola
-
monterey
-
dulcitol
-
caries-free
-
hayward
-
drug development
-
adonitol
-
pharmacology
-
synthesis
-
medicine
- 3.5.3.6
- ornithine
- streptococcus
- argininosuccinate
-
pegylated
- levan
-
king
- carbamate
-
reisolated
- mycoplasma
-
water-soaked
- syringae
-
greenhouse
- urease
- arginase
-
adi-peg20
-
lopat
-
dna-dna
- melibiose
-
pathovars
- d-sorbitol
-
midi
- gordonii
- l-citrulline
-
voges-proskauer
-
newark
- l-rhamnose
-
symptomless
- aesculin
- d-mannitol
-
rep-pcr
-
ncppb
-
surface-sterilized
- lecithinase
-
glistening
- cichorii
- amygdalin
-
arginine-dependent
-
supragingival
-
deimination
-
phytopathology
- sanguinis
-
non-spore-forming
- salicin
-
malolactic
- maculicola
-
monterey
- dulcitol
-
caries-free
-
hayward
- drug development
- adonitol
- pharmacology
- synthesis
- medicine
Reaction
Synonyms
ADI, ArcA, arcA-1, arcA-2, arginine deiminase, arginine dihydrolase, arginine-degrading enzyme, citrulline iminase, deiminase, arginine, L-arginine deiminase, LADI, lymphocyte blastogenesis inhibitory factor, More, PaADI, PAD, PAD2, peptidylarginine deiminase, PpADI, Streptococcal acid glycoprotein
ECTree
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Substrates Products
Substrates Products on EC 3.5.3.6 - arginine deiminase
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REACTION DIAGRAM
agmatine-L-Arg + H2O
N5-carbamoyl-N2-[4-(carbamoylamino)butyl]-L-ornithine + NH3
-
3.2% activity compared to L-Arg
-
-
?
bradykinin-L-Arg + H2O
bradykinin-L-citrulline + NH3
-
18.8% activity compared to L-Arg
-
-
?
D-Arg + H2O
D-citrulline + NH3
-
0.38% of the activity with L-Arg
-
-
?
homoarginine + H2O
(2S)-2-amino-6-[(aminocarbonyl)amino]hexanoic acid + NH3
-
50% activity compared to L-Arg
-
-
?
KRPPGFSPL + H2O
L-lysyl-N5-carbamoyl-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-leucine + NH3
-
3.1% activity compared to L-Arg
-
-
?
L-alpha-amino-beta-guanidinepropionic acid + H2O
2-amino-3-carbamoylpropionic acid + NH3
-
-
-
-
?
L-alpha-amino-beta-guanidinopropionic acid + H2O
2-amino-3-carbamoylpropionic acid + NH3
-
-
-
-
?
L-alpha-amino-gamma-guanidinobutyric acid + H2O
2-amino-4-carbamoylbutanoic acid + NH3
-
-
-
-
?
L-arginine hydroxamate + H2O
?
-
68.2% activity compared to L-Arg
-
-
?
L-argininic acid + H2O
(2S)-5-[(aminocarbonyl)amino]-2-hydroxypentanoic acid + NH3
-
0.032% of the activity with L-Arg
-
-
?
L-canavanine + H2O
(2S)-2-amino-4-[[(aminocarbonyl)amino]oxy]butanoic acid + NH3
-
2.3% of the activity with L-Arg
-
-
?
L-canavanine + H2O
O-ureidohomoserine + NH3
-
via enzyme Cys-bound S-alkyl-thiouronium intermediate, residues Asp166 and Asp280 are involved, overview
product identification by mass spectrometry
-
?
L-canavanine-L-Arg + H2O
O-ureido-L-homoserine + NH3
-
2.5% activity compared to L-Arg
-
-
?
L-homoarginine + H2O
(2S)-2-amino-6-[(aminocarbonyl)amino]hexanoic acid + NH3
-
0.05% of the activity with L-Arg
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline methyl ester + NH3
-
-
-
?
Nalpha-methyl-L-Arg + H2O
Nalpha-methyl-L-citrulline + NH3
-
0.75% of the activity with L-Arg
-
-
?
Nomega-hydroxy-L-arginine + H2O
Nomega-hydroxy-L-citrulline + NH3
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2.1% activity compared to L-Arg
-
-
?
Nomega-methyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
?
benzoyl-L-citrulline ethyl ester + NH3
-
8.1% activity compared to L-Arg
-
-
?
benzoyl-L-arginine ethyl ester + H2O
benzoyl-L-citrulline ethyl ester + NH3
-
8.1% activity compared to L-Arg
-
-
?
L-Arg + H2O
citrulline + NH3
-
caffeine markedly increases the formation of arginine deiminase when dextrin, but not maltotriose, serves as the energy source
-
-
?
L-Arg + H2O
citrulline + NH3
-
caffeine markedly increases the formation of arginine deiminase when dextrin, but not maltotriose, serves as the energy source
-
-
?
L-Arg + H2O
citrulline + NH3
enzyme of catabolism of Arg to citrulline in the arginine dihydrolase pathway
-
?
L-Arg + H2O
citrulline + NH3
-
enzyme of the arginine dihydrolase pathway. Arginine metabolism via this pathway plays a significant role in energy metabolism by providing a site for anaerobic substrate level phosphorylation
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
Lentilactobacillus hilgardii Microenos HP
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
Levilactobacillus brevis EQUILAIT
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
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in vivo and in vitro anti-tumor activities for 6 kinds of mouse ascites tumor cell lines
-
-
?
L-Arg + H2O
citrulline + NH3
-
cytostatic activity, the enzyme-induced arginine depletion may inhibit protein synthesis and results in the protection of apoptotic cell death that requires new protein synthesis
-
-
?
L-Arg + H2O
citrulline + NH3
-
the recombinant enzyme inhibits the growth of two mouse cells lines hepatoma MH134 and fibrosarcoma Meth A
-
-
?
L-Arg + H2O
citrulline + NH3
-
deletion of the essential nutrient L-Arg by arginine deiminase significantly inhibits cell growth and activation in T lymphoblasts, accompanied by the induction of apoptotic cell death
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
potent inhibition of proliferation of human T cells by streptococcal cell extract is due to activity of arginine deiminase
-
-
?
L-Arg + H2O
citrulline + NH3
-
enzyme of catabolism of Arg to citrulline in the arginine dihydrolase pathway
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview, ADI is a potential anti-angiogenic agent and is effective in the treatment of leukemia
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
the enzyme reduces extracellular arginine, which inhibits viral replication, ADI bound to PEG 20 000 probably reduces hepatitis C virus viral titers through nitric oxide-dependent effects
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
the enzyme is involved in the arginine metabolism, e.g. in strain Lp60, which accumulates L-citrulline, the precursor of the carcinogen ethyl-carbamate, showing high activity, while the activity of ornithine transcarbamylase is low
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
the enzyme is involved in the arginine metabolism, e.g. in strain Lp60, which accumulates L-citrulline, the precursor of the carcinogen ethyl-carbamate, showing high activity, while the activity of ornithine transcarbamylase is low
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
ADI is the key enzyme of the ADI pathway
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
-
-
?
L-arginine + H2O
L-citrulline + NH3
arginine catabolism
-
-
?
L-arginine + H2O
L-citrulline + NH3
arginine catabolism
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
ADi shows inhibitory ability on the proliferation of mouse melanoma cells
-
-
ir
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
substrate binding abilities of recombinant wild-type and mutant enzymes, substrate binding induces structural changes, overview
-
-
ir
L-arginine + H2O
L-citrulline + NH3
-
arginine deiminase enhances human MCF-7 cell radiosensitivity by inducing changes in the expression of cell cycle-related proteins, e.g. upregulation of CDK inhibitors p21 and p27 and downregulation of c-Myc, ammonia is not involved, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
via enzyme Cys-bound S-alkyl-thiouronium intermediate, residues Asp166 and Asp280 are involved, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
via enzyme Cys-bound S-alkyl-thiouronium intermediate, substrate binding and enzyme-intermediate structure of wild-type and mutant enzymes, modeling, overview
-
-
ir
L-arginine + H2O
L-citrulline + NH3
ADI catalyzes the first step of the energy-producing arginine degradation pathway found in certain microorganisms, which ultimately leads to ornithine, carbamate, and ATP, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
O-ureido-L-homoserine + NH3
-
two competing pathways, slow substrate inhibition or irreversible inhibition, branch at the Cys-alkylthiouronium ion intermediate: one pathway leads to direct formation of O-ureido-L-homoserine via a reactive thiouronium intermediate. The other pathway leads to an inactive form of the enzyme, a Cys-alkylisothiourea adduct, mechanism and structure, overview
-
-
?
L-canavanine + H2O
O-ureido-L-homoserine + NH3
-
two competing pathways, slow substrate inhibition or irreversible inhibition, branch at the Cys-alkylthiouronium ion intermediate: one pathway leads to direct formation of O-ureido-L-homoserine via a reactive thiouronium intermediate. The other pathway leads to an inactive form of the enzyme, a Cys-alkylisothiourea adduct, mechanism and structure, overview
-
-
?
L-canavanine + H2O
O-ureido-L-homoserine + NH3
-
two competing pathways, slow substrate inhibition or irreversible inhibition, branch at the Cys-alkylthiouronium ion intermediate: one pathway leads to direct formation of O-ureido-L-homoserine via a reactive thiouronium intermediate. The other pathway leads to an inactive form of the enzyme, a Cys-alkylisothiourea adduct, mechanism and structure, overview
-
-
?
L-canavanine + H2O
O-ureido-L-homoserine + NH3
-
two competing pathways, slow substrate inhibition or irreversible inhibition, branch at the Cys-alkylthiouronium ion intermediate: one pathway leads to direct formation of O-ureido-L-homoserine via a reactive thiouronium intermediate. The other pathway leads to an inactive form of the enzyme, a Cys-alkylisothiourea adduct, mechanism and structure, overview
-
-
?
L-canavanine + H2O
O-ureido-L-homoserine + NH3
two competing pathways, slow substrate inhibition or irreversible inhibition, branch at the Cys-alkylthiouronium ion intermediate: one pathway leads to direct formation of O-ureido-L-homoserine via a reactive thiouronium intermediate. The other pathway leads to an inactive form of the enzyme, a Cys-alkylisothiourea adduct, mechanism and structure, overview
-
-
?
L-canavanine + H2O
O-ureido-L-homoserine + NH3
slow substrate, reaction via Cys-alkylthiouronium ion intermediate, two competing pathways follow that branch at the Cys-alkylthiouronium ion intermediate, overview
-
-
?
N-alpha-benzoyl-L-citrulline + NH3
-
54.5% activity compared to L-Arg
-
-
?
N-alpha-benzoyl-L-arginine + H2O
N-alpha-benzoyl-L-citrulline + NH3
-
54.5% activity compared to L-Arg
-
-
?
Nomega-amino-L-arginine + H2O
hydrazine + L-citrulline
-
-
-
?
protein L-Arg + H2O
protein L-citrulline + NH3
-
-
-
-
?
?
-
does not accept agmatine, L-homoarginine, Nalpha-benzoyl-L-arginine ethyl ester as substrate
-
-
?
additional information
?
-
-
does not accept agmatine, L-homoarginine, Nalpha-benzoyl-L-arginine ethyl ester as substrate
-
-
?
additional information
?
-
does not accept agmatine, L-homoarginine, Nalpha-benzoyl-L-arginine ethyl ester as substrate
-
-
?
additional information
?
-
-
anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma, overview
-
-
?
additional information
?
-
-
arginine deiminase formulated with polyethyleneglycol specifically inhibits growth of cell lines lacking argininosuccinate synthetase, inducing caspase activation and induction of apoptosis
-
-
?
additional information
?
-
-
the recombinant enzyme reduces inducible nitric oxide synthase-mediated neurotoxicity in a coculture of neurons and microglia
-
-
?
additional information
?
-
-
ADI has anti-cancer activity by causing depletion of L-arginine by reducing the circulating amount, fusion of ADI to 20 kDa PEG improves its pharmaceutical efficiency, overview
-
-
?
additional information
?
-
-
the enzyme shows anti-tumor activity inhibiting growth of several murine and human tumor cell lines in vitro and in vivo
-
-
?
additional information
?
-
-
native and recombinant enzyme shows anti-angiogenic and anti-tumor activity inhibiting growth of several murine and human tumor cell lines in vitro and in vivo, e.g. against human umbilical vein cells, HUVEC
-
-
?
additional information
?
-
-
no activity with Nomega,Nomega-dimethyl-L-arginine
-
-
?
additional information
?
-
-
no activity with Nomega,Nomega-dimethyl-L-arginine
-
-
?
additional information
?
-
structural basis for substrate specificity, overview
-
-
?
additional information
?
-
-
structural basis for substrate specificity, overview
-
-
?
additional information
?
-
the recombinant enzyme shows anti-tumor activity inhibiting growth of human Hep-G2 tumor cell line
-
-
?
additional information
?
-
the recombinant enzyme shows anti-tumor activity inhibiting growth of human Hep-G2 tumor cell line
-
-
?
additional information
?
-
-
the enzyme shows anti-tumor activity in murine leukemia lymphoblasts in vitro
-
-
?
additional information
?
-
-
ArcA inhibits production of a major adhesin, FimA, in Porphyromonas gingivalis
-
-
?
additional information
?
-
-
ArcA inhibits production of a major adhesin, FimA, in Porphyromonas gingivalis
-
-
?
additional information
?
-
-
the arginine deiminase system enables Streptococcus suis to overcome oxygen and nutrient starvation and to tolerate acidic environment. Thus the arginine deiminase system might facilitate Streptococcus suis survival within the different niches of the host and thereby probably contributes to Streptococcus suis pathogenesis
-
-
?