3.5.3.6: arginine deiminase
This is an abbreviated version!
For detailed information about arginine deiminase, go to the full flat file.
Word Map on EC 3.5.3.6
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3.5.3.6
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ornithine
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streptococcus
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argininosuccinate
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pegylated
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levan
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king
-
carbamate
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reisolated
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mycoplasma
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water-soaked
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syringae
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greenhouse
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urease
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arginase
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adi-peg20
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lopat
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dna-dna
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melibiose
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pathovars
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d-sorbitol
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midi
-
gordonii
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l-citrulline
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voges-proskauer
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newark
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l-rhamnose
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symptomless
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aesculin
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d-mannitol
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rep-pcr
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ncppb
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surface-sterilized
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lecithinase
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glistening
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cichorii
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amygdalin
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arginine-dependent
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supragingival
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deimination
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phytopathology
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sanguinis
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non-spore-forming
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salicin
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malolactic
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maculicola
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monterey
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dulcitol
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caries-free
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hayward
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drug development
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adonitol
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pharmacology
-
synthesis
-
medicine
- 3.5.3.6
- ornithine
- streptococcus
- argininosuccinate
-
pegylated
- levan
-
king
- carbamate
-
reisolated
- mycoplasma
-
water-soaked
- syringae
-
greenhouse
- urease
- arginase
-
adi-peg20
-
lopat
-
dna-dna
- melibiose
-
pathovars
- d-sorbitol
-
midi
- gordonii
- l-citrulline
-
voges-proskauer
-
newark
- l-rhamnose
-
symptomless
- aesculin
- d-mannitol
-
rep-pcr
-
ncppb
-
surface-sterilized
- lecithinase
-
glistening
- cichorii
- amygdalin
-
arginine-dependent
-
supragingival
-
deimination
-
phytopathology
- sanguinis
-
non-spore-forming
- salicin
-
malolactic
- maculicola
-
monterey
- dulcitol
-
caries-free
-
hayward
- drug development
- adonitol
- pharmacology
- synthesis
- medicine
Reaction
Synonyms
ADI, ArcA, arcA-1, arcA-2, arginine deiminase, arginine dihydrolase, arginine-degrading enzyme, citrulline iminase, deiminase, arginine, L-arginine deiminase, LADI, lymphocyte blastogenesis inhibitory factor, More, PaADI, PAD, PAD2, peptidylarginine deiminase, PpADI, Streptococcal acid glycoprotein
ECTree
3.5.3.6 arginine deiminaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.5.3.6 - arginine deiminase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-Arg + H2O
citrulline + NH3
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caffeine markedly increases the formation of arginine deiminase when dextrin, but not maltotriose, serves as the energy source
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-
?
L-Arg + H2O
citrulline + NH3
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caffeine markedly increases the formation of arginine deiminase when dextrin, but not maltotriose, serves as the energy source
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-
?
L-Arg + H2O
citrulline + NH3
enzyme of catabolism of Arg to citrulline in the arginine dihydrolase pathway
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?
L-Arg + H2O
citrulline + NH3
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enzyme of the arginine dihydrolase pathway. Arginine metabolism via this pathway plays a significant role in energy metabolism by providing a site for anaerobic substrate level phosphorylation
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-
?
L-Arg + H2O
citrulline + NH3
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catabolism of Arg by arginine deiminase pathway
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-
?
L-Arg + H2O
citrulline + NH3
Lentilactobacillus hilgardii Microenos HP
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catabolism of Arg by arginine deiminase pathway
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-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
Levilactobacillus brevis EQUILAIT
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catabolism of Arg by arginine deiminase pathway
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-
?
L-Arg + H2O
citrulline + NH3
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in vivo and in vitro anti-tumor activities for 6 kinds of mouse ascites tumor cell lines
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-
?
L-Arg + H2O
citrulline + NH3
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cytostatic activity, the enzyme-induced arginine depletion may inhibit protein synthesis and results in the protection of apoptotic cell death that requires new protein synthesis
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-
?
L-Arg + H2O
citrulline + NH3
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the recombinant enzyme inhibits the growth of two mouse cells lines hepatoma MH134 and fibrosarcoma Meth A
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-
?
L-Arg + H2O
citrulline + NH3
-
deletion of the essential nutrient L-Arg by arginine deiminase significantly inhibits cell growth and activation in T lymphoblasts, accompanied by the induction of apoptotic cell death
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-
?
L-Arg + H2O
citrulline + NH3
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catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
catabolism of Arg by arginine deiminase pathway
-
-
?
L-Arg + H2O
citrulline + NH3
-
potent inhibition of proliferation of human T cells by streptococcal cell extract is due to activity of arginine deiminase
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-
?
L-Arg + H2O
citrulline + NH3
-
enzyme of catabolism of Arg to citrulline in the arginine dihydrolase pathway
-
-
?
L-arginine + H2O
L-citrulline + NH3
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first step of the arginine deiminase pathway, overview
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-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
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first step of the arginine deiminase pathway, overview, ADI is a potential anti-angiogenic agent and is effective in the treatment of leukemia
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-
?
L-arginine + H2O
L-citrulline + NH3
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the enzyme reduces extracellular arginine, which inhibits viral replication, ADI bound to PEG 20 000 probably reduces hepatitis C virus viral titers through nitric oxide-dependent effects
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-
?
L-arginine + H2O
L-citrulline + NH3
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the enzyme is involved in the arginine metabolism, e.g. in strain Lp60, which accumulates L-citrulline, the precursor of the carcinogen ethyl-carbamate, showing high activity, while the activity of ornithine transcarbamylase is low
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-
?
L-arginine + H2O
L-citrulline + NH3
-
the enzyme is involved in the arginine metabolism, e.g. in strain Lp60, which accumulates L-citrulline, the precursor of the carcinogen ethyl-carbamate, showing high activity, while the activity of ornithine transcarbamylase is low
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
ADI is the key enzyme of the ADI pathway
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-
?
L-arginine + H2O
L-citrulline + NH3
-
-
-
?
L-arginine + H2O
L-citrulline + NH3
arginine catabolism
-
-
?
L-arginine + H2O
L-citrulline + NH3
arginine catabolism
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
ADi shows inhibitory ability on the proliferation of mouse melanoma cells
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-
ir
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
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-
?
L-arginine + H2O
L-citrulline + NH3
-
arginine deiminase enhances human MCF-7 cell radiosensitivity by inducing changes in the expression of cell cycle-related proteins, e.g. upregulation of CDK inhibitors p21 and p27 and downregulation of c-Myc, ammonia is not involved, overview
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-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
ADI catalyzes the first step of the energy-producing arginine degradation pathway found in certain microorganisms, which ultimately leads to ornithine, carbamate, and ATP, overview
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-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
first step of the arginine deiminase pathway, overview
-
-
?
protein L-Arg + H2O
protein L-citrulline + NH3
-
-
-
-
?
additional information
?
-
-
anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma, overview
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-
?
additional information
?
-
-
arginine deiminase formulated with polyethyleneglycol specifically inhibits growth of cell lines lacking argininosuccinate synthetase, inducing caspase activation and induction of apoptosis
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-
?
additional information
?
-
-
the recombinant enzyme reduces inducible nitric oxide synthase-mediated neurotoxicity in a coculture of neurons and microglia
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-
?
additional information
?
-
-
ADI has anti-cancer activity by causing depletion of L-arginine by reducing the circulating amount, fusion of ADI to 20 kDa PEG improves its pharmaceutical efficiency, overview
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-
?
additional information
?
-
-
the enzyme shows anti-tumor activity inhibiting growth of several murine and human tumor cell lines in vitro and in vivo
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-
?
additional information
?
-
-
native and recombinant enzyme shows anti-angiogenic and anti-tumor activity inhibiting growth of several murine and human tumor cell lines in vitro and in vivo, e.g. against human umbilical vein cells, HUVEC
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-
?
additional information
?
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the recombinant enzyme shows anti-tumor activity inhibiting growth of human Hep-G2 tumor cell line
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-
?
additional information
?
-
the recombinant enzyme shows anti-tumor activity inhibiting growth of human Hep-G2 tumor cell line
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-
?
additional information
?
-
-
the enzyme shows anti-tumor activity in murine leukemia lymphoblasts in vitro
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-
?
additional information
?
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-
ArcA inhibits production of a major adhesin, FimA, in Porphyromonas gingivalis
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-
?
additional information
?
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-
ArcA inhibits production of a major adhesin, FimA, in Porphyromonas gingivalis
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-
?
additional information
?
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-
the arginine deiminase system enables Streptococcus suis to overcome oxygen and nutrient starvation and to tolerate acidic environment. Thus the arginine deiminase system might facilitate Streptococcus suis survival within the different niches of the host and thereby probably contributes to Streptococcus suis pathogenesis
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-
?
