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3.5.3.6: arginine deiminase

This is an abbreviated version!
For detailed information about arginine deiminase, go to the full flat file.

Word Map on EC 3.5.3.6

Reaction

L-arginine
+
H2O
=
L-citrulline
 +
NH3

Synonyms

ADI, ArcA, arcA-1, arcA-2, arginine deiminase, arginine dihydrolase, arginine-degrading enzyme, citrulline iminase, deiminase, arginine, L-arginine deiminase, LADI, lymphocyte blastogenesis inhibitory factor, More, PaADI, PAD, PAD2, peptidylarginine deiminase, PpADI, Streptococcal acid glycoprotein

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.3 In linear amidines
                3.5.3.6 arginine deiminase

Expression

Expression on EC 3.5.3.6 - arginine deiminase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
arginine enhances the transcription of arcA2. Expressions of arcA2 is dramatically increased after infection, highlighting the importance of arginine metabolism for intracellular survival. The transcription of arcA2 is augmented under anaerobic and acidic conditions
deviations from the optimal pH (pH 5.0 and pH 7.0) results in an overall decline of the relative expression level
-
expression of arcA1 is augmented under anaerobic conditions, as well as under acidic conditions (pH 2-4), relative to the respective controls under aerobic conditions and at normal pH values (PBS at pH 7.0). Expression of arcA1 is dramatically increased after infection, highlighting the importance of arginine metabolism for intracellular survival
no repressive effect on the arginine deiminase pathway genes by glucose supplement
over-expressed in isogenic colony morphology types II and III compared with parental type I. RT-PCR results confirm that arcA transcripts are increased in the presence of arginine, in a low oxygen concentration and in acid
-
repressive effects of arginine had on arcA1 expression. The transcriptional level of arcA1 is upregulated after a temperature shift from 20°C to 37°C
the highest relative gene expression level is in the end exponential growth phase in the case of Lactobacillus sakei CTC 494 and in the mid-exponential growth phase of Lactobacillus sakei 23K. The environmental pH influences the relative expression level of the arc operon, as shown for Lactobacillus sakei CTC 494, with the highest relative expression level occurring at the optimal pH for growth (pH 6.0)
-
upon temperature shift from 20°C to 37°C, arcA2 transcription is downregulated