3.5.3.15: protein-arginine deiminase

This is an abbreviated version!
For detailed information about protein-arginine deiminase, go to the full flat file.

Reaction

Synonyms

deiminase, protein (arginine), HL-60 PAD, hPADI2, hPADI4, hPADVI, PAD, PAD 1, PAD 2, PAD 3, PAD 4, PAD II, PAD IV, PAD type 2, PAD-4, PAD-H19, PAD-R11, PAD-R4, PAD1, PAD2, PAD3, PAD4, PAD6, PADI1, Padi2, PADI3, PADI4, peptidyl arginine deiminas 4, peptidyl arginine deiminase, peptidyl arginine deiminase 2, peptidyl-arginine deiminase, peptidylarginine deiminase, peptidylarginine deiminase 1, peptidylarginine deiminase 2, peptidylarginine deiminase 3, peptidylarginine deiminase 4, peptidylarginine deiminase 6, peptidylarginine deiminase isoform VI, peptidylarginine deiminase IV, peptidylarginine deiminase type 4, Peptidylarginine deiminase type alpha, peptidylarginine deiminase type I, peptidylarginine deiminase type II, peptidylarginine deiminase type III, peptidylarginine deiminase type VI, peptidylarginine deiminase-4, PPAD, protein arginine deiminase, protein arginine deiminase 2, protein arginine deiminase 3, protein arginine deiminase 4

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.3 In linear amidines

                3.5.3.15 protein-arginine deiminase

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Results	in table
12	Activating Compound
2099	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
12	Crystallization (Commentary)
1778	Disease/ Diagnostics
9	Expression
20	General Information
2	General Stability
35	IC50 Value
123	Inhibitors
178	kcat/KM [mM/s]
7	Ki Value [mM]
237	KM Value [mM]
40	Localization
53	Metals/Ions
24	Molecular Weight [Da]
72	Natural Substrates/ Products (Substrates)
199	Organism
1	Pathway
62	PDB ID
26	pH Optimum
7	pH Range
2	pI Value
5	Posttranslational Modification
136	Protein Variants
23	Purification (Commentary)
1	Reaction
1	Reaction Type
152	Reference
257	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
510	Substrates and Products (Substrate)
20	Subunits
224	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
203	Turnover Number [1/s]

pH Range

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pH Range on EC 3.5.3.15 - protein-arginine deiminase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5.2 - 8.9

3 entries

6 - 10

Homo sapiens

-

pH 6.0: about 75% of maximal activity, pH 10.0: about 50% of maximal activity, hPADI2

663858

6.5 - 8

Homo sapiens

Q9UM07

pH 6.5: about 50% of maximal activity, pH 8.0: about 70% of maximal activity

664055

6.5 - 9

Homo sapiens

-

pH 6.5: about 70% of maximal activity, pH 9.0: about 50% of maximal activity, hPADI4

663858

7 - 11

Porphyromonas gingivalis

-

pH 7.0: about 45% of maximal activity, pH 11.0: about 40% of maximal activity

209427

5.2 - 8.9

Homo sapiens

Q9ULC6, Q9ULW8

pH 5.2: about 60% of maximal activity, pH 8.9: about 85% of maximal activity, deamination of fillagrin, peptidylarginine deiminase 1

664565

5.2 - 8.9

Homo sapiens

Q9ULC6, Q9ULW8

pH 5.2: about 70% of maximal activity, pH 8.9: about 50% of maximal activity, deimination of fillagrin, peptidylarginine deiminase 3

664565

5.2 - 8.9

Homo sapiens

Q9ULC6, Q9ULW8

pH 5.2: about 70% of maximal activity, pH 8.9: about 75% of maximal activity, deimination of fillagrin, peptidylarginine deiminase 2

664565