3.5.3.15: protein-arginine deiminase
This is an abbreviated version!
For detailed information about protein-arginine deiminase, go to the full flat file.
Word Map on EC 3.5.3.15
-
3.5.3.15
-
citrullination
-
rheumatoid
-
arthritis
-
histone
-
autoimmune
-
deimination
-
autoantibody
-
anti-citrullinated
-
chromatin
-
acpas
-
epitope
-
synovial
-
padis
-
porphyromonas
-
anti-ccp
-
netosis
-
periodontitis
-
gingivalis
-
sclerosis
-
fibrinogen
-
anti-cyclic
-
vimentin
-
hla-drb1
-
elastase
-
autoantigens
-
ptpn22
-
decondensation
-
cl-amidine
-
lupus
-
erythematosus
-
myeloperoxidase
-
pharmacology
-
self-antigens
-
ra-associated
-
gingipains
-
synoviocytes
-
rheumatology
-
medicine
-
arginyl
-
erosive
-
analysis
-
drug development
-
fibrin
-
non-hla
-
filaggrin
- 3.5.3.15
-
citrullination
-
rheumatoid
- arthritis
- histone
- autoimmune
-
deimination
- autoantibody
-
anti-citrullinated
- chromatin
-
acpas
- epitope
- synovial
-
padis
- porphyromonas
-
anti-ccp
-
netosis
- periodontitis
- gingivalis
- sclerosis
- fibrinogen
-
anti-cyclic
- vimentin
-
hla-drb1
- elastase
- autoantigens
- ptpn22
-
decondensation
- cl-amidine
-
lupus
- erythematosus
- myeloperoxidase
- pharmacology
-
self-antigens
-
ra-associated
-
gingipains
- synoviocytes
-
rheumatology
- medicine
-
arginyl
-
erosive
- analysis
- drug development
- fibrin
-
non-hla
- filaggrin
Reaction
Synonyms
deiminase, protein (arginine), HL-60 PAD, hPADI2, hPADI4, hPADVI, PAD, PAD 1, PAD 2, PAD 3, PAD 4, PAD II, PAD IV, PAD type 2, PAD-4, PAD-H19, PAD-R11, PAD-R4, PAD1, PAD2, PAD3, PAD4, PAD6, PADI1, Padi2, PADI3, PADI4, peptidyl arginine deiminas 4, peptidyl arginine deiminase, peptidyl arginine deiminase 2, peptidyl-arginine deiminase, peptidylarginine deiminase, peptidylarginine deiminase 1, peptidylarginine deiminase 2, peptidylarginine deiminase 3, peptidylarginine deiminase 4, peptidylarginine deiminase 6, peptidylarginine deiminase isoform VI, peptidylarginine deiminase IV, peptidylarginine deiminase type 4, Peptidylarginine deiminase type alpha, peptidylarginine deiminase type I, peptidylarginine deiminase type II, peptidylarginine deiminase type III, peptidylarginine deiminase type VI, peptidylarginine deiminase-4, PPAD, protein arginine deiminase, protein arginine deiminase 2, protein arginine deiminase 3, protein arginine deiminase 4
ECTree
3.5.3.15 protein-arginine deiminaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.5.3.15 - protein-arginine deiminase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-[3-(2,5-dioxo-1-phenylimidazolidin-4-yl)propyl]guanidine + H2O
N-[3-(2,5-dioxo-1-phenylimidazolidin-4-yl)propyl]urea + NH3
-
-
-
?
1-[3-(2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propyl]guanidine + H2O
N-[[6-(benzyloxy)-1H-indol-2-yl]methyl]urea + NH3
-
-
-
?
1-[3-(2,5-dioxoimidazolidin-4-yl)propyl]guanidine + H2O
N-[3-(2,5-dioxoimidazolidin-4-yl)propyl]urea + NH3
-
-
-
?
1-[3-[1-(biphenyl-3-ylmethyl)-2,5-dioxoimidazolidin-4-yl]propyl]guanidine + H2O
N-(3-[1-[([1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)urea + NH3
-
-
-
?
1-[[6-(benzyloxy)-1H-indol-2-yl]methyl]guanidine + H2O
N-[[6-(benzyloxy)-1H-indol-2-yl]methyl]urea + NH3
-
-
-
?
2-acetyl-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys + H2O
2-acetyl-Gly-Cit-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys + NH3
-
-
-
-
?
3-acetyl-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys + H2O
3-acetyl-Cit-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys + NH3
-
-
-
-
?
4-carbamimidamido-N-(diphenylmethyl)butanamide + H2O
4-(carbamoylamino)-N-(diphenylmethyl)butanamide + NH3
-
-
-
?
4-[4-(3-carbamimidamidopropyl)-2,5-dioxoimidazolidin-1-yl]-2-ethoxy-N-(4-methoxyphenyl)benzamide + H2O
4-[4-[3-(carbamoylamino)propyl]-2,5-dioxoimidazolidin-1-yl]-2-ethoxy-N-(4-methoxyphenyl)benzamide + NH3
-
-
-
?
4-[4-(3-carbamimidamidopropyl)-2,5-dioxoimidazolidin-1-yl]-N-(4-methoxyphenyl)benzamide + H2O
4-[4-[3-(carbamoylamino)propyl]-2,5-dioxoimidazolidin-1-yl]-N-(4-methoxyphenyl)benzamide + NH3
-
-
-
?
4-[4-(3-carbamimidamidopropyl)-2,5-dioxoimidazolidin-1-yl]-N-phenylbenzamide + H2O
4-[4-[3-(carbamoylamino)propyl]-2,5-dioxoimidazolidin-1-yl]-N-phenylbenzamide + NH3
-
-
-
?
4-[4-[3-(carbamoylamino)propyl]-2,5-dioxoimidazolidin-1-yl]-N-(4-methoxyphenyl)benzamide + H2O
4-[4-[3-(carbamoylamino)propyl]-2,5-dioxoimidazolidin-1-yl]-2-methoxy-N-(4-methoxyphenyl)benzamide + NH3
-
-
-
?
Ac-Ser-Gly-Ala-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val + H2O
?
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-acetyl-Lys-Gly-Gly-acetyl-Lys-Gly-Leu-Gly-acetyl-Lys-Gly-Gly-Ala-acetyl-Lys + H2O
?
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-acetyl-Lys-Gly-Gly-acetyl-Lys-Gly-Leu-Gly-acetyl-Lys-Gly-Gly-Ala-acetyl-Lys-Arg-His-Arg-acetyl-Lys-Val + H2O
?
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly + H2O
Ac-Ser-Gly-Cit-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly + NH3
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala + H2O
Ac-Ser-Gly-Cit-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala + NH3
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Ala-Val + H2O
?
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Ala-Arg-His-Arg-Lys-Val + H2O
?
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys + H2O
Ac-Ser-Gly-Cit-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys + NH3
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Ala-His-Arg-Ala-Val + H2O
?
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His + H2O
?
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Ala-Ala-Val + H2O
?
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val + H2O
?
-
-
-
-
?
Ac-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Lys-His-Lys-Ala-Val + H2O
Ac-Ser-Gly-Cit-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Lys-His-Lys-Ala-Val + NH3
-
-
-
-
?
benzoyl-Arg methyl ester + H2O
benzoyl-citrulline methyl ester + NH3
-
-
-
-
?
benzoyl-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-citrulline-4-methylcoumarin-7-amide + NH3
-
-
-
-
?
benzoyl-D-Arg-p-nitroanilide + H2O
benzoyl-citrulline-p-nitroanilide + NH3
-
18% of the rate of the L-isomer
-
-
?
benzoyl-homoarginine ethyl ester + H2O
(2S)-2-aminobenzoyl-6-[(aminocarbonyl)amino]hexanoic acid + NH3
-
-
-
-
?
benzoyl-L-Arg-p-nitroanilide + H2O
benzoyl-citrulline-p-nitroanilide + NH3
-
-
-
-
?
benzoyl-L-arginine methyl ester + H2O
benzoyl-L-citrulline methyl ester + NH3
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Phe-citrulline-4-methylcoumarin-7-amide + NH3
-
-
-
-
?
beta-actin L-arginine + H2O
beta-actin L-citrulline + NH3
substrate for isoform PAD2 only
-
-
?
citrullinated histone H3 L-arginine + H2O
?
substrate for isoform PAD4 only
-
-
?
CRGKA + H2O
?
-
Giardia lamblia ADI specifically binds to and citrullinates the arginine in the conserved CRGKA tail of variant-specific surface proteins affecting both antigenic switching and antibody mediated cell death
-
-
?
CXCL5-L-Arg + H2O
CXCL5-L-citrulline + NH3
-
PAD site-specifically deiminates L-Arg9 in CXCL5 to L-citrulline
-
-
?
filaggrin L-Arg + H2O
filaggrin citrulline + NH3
-
-
-
?
gamma-actin L-arginine + H2O
gamma-actin L-citrulline + NH3
substrate for isoform PAD2 only
-
-
?
glial fibrillary acidic protein L-arginine + H2O
glial fibrillary acidic protein L-citrulline + NH3
-
-
-
?
glial fibrillary acidic protein-L-Arg + H2O
glial fibrillary acidic protein-L-citrulline + NH3
-
-
-
?
glial fibrillary acidic protein-L-arginine + H2O
glial fibrillary acidic protein-L-citrulline + NH3
glycogen phosphorylase b + H2O
?
-
specific deimination by peptidylarginine deiminase has a pronounced effect on the binding of some allosteric effectors with the enzyme and hampers the association of phosphorylase b dimers into tetramers in the presence of AMP
-
-
?
glycogen phosphorylase b + H2O
? + NH3
-
specific deimination by peptidylarginine deiminase has a pronounced effect on the binding of some allosteric effectors with the enzyme and hampers the association of phosphorylase b dimers into tetramers in the presence of AMP
-
-
?
heat shock protein 8 L-Arg + H2O
heat shock protein 8 L-citrulline + NH3
-
-
-
?
histone H2A L-arginine + H2O
histone H2A L-citrulline + NH3
-
deimination occurs at Arg3 of the N-terminal sequence acetyl-SGRGK
-
-
?
histone H3 L-Arg + H2O
histone H3 L-citrulline + NH3
-
citrullination activity is limited to diestrus with histone H3
-
-
?
histone H4 L-arginine + H2O
histone H4 L-citrulline + NH3
-
deimination occurs at Arg3 of the N-terminal sequence acetyl-SGRGK
-
-
?
human vimentin L-arginine + H2O
human vimentin L-citrulline + NH3
-
-
-
-
?
L-Arg-Gly + H2O
L-Cit-Gly + NH3
-
75% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
L-Arg-Gly-Gly + H2O
L-Cit-Gly-Gly + NH3
-
66% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
L-canavanine + H2O
? + NH3
-
0.3% activity compared to L-arginine
-
-
?
L-homoarginine + H2O
? + NH3
-
0.3% activity compared to L-arginine
-
-
?
L-Leu-Trp-Met-Arg + H2O
L-Leu-Trp-Met-Cit + NH3
-
45% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
L-Met-Arg-Phe + H2O
L-Met-Cit-Phe + NH3
-
the substrate shows fastest rate of citrullination with 158% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
L-octopine + H2O
? + NH3
-
16.7% activity compared to L-arginine
-
-
?
myelin basic protein-L-Arg + H2O
myelin basic protein-L-citrulline + NH3
-
-
-
?
N-(3-[1-[(2'-chloro-3'-fluoro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)guanidine + H2O
N-(3-[1-[(2'-chloro-3'-fluoro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)urea + NH3
-
-
-
?
N-(3-[1-[(2'-chloro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)guanidine + H2O
N-(3-[1-[(2'-chloro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)urea + NH3
-
-
-
?
N-(3-[1-[([1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)urea + H2O
N-(3-[1-[(3'-fluoro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)urea + NH3
-
-
-
?
N-(biphenyl-3-ylmethyl)-4-carbamimidamidobutanamide + H2O
N-[([1,1''-biphenyl]-3-yl)methyl]-4-(carbamoylamino)butanamide + NH3
-
-
-
?
N-alpha-benzoyl-L-arginine amide + H2O
N-alpha-benzoyl-L-citrulline amide + NH3
-
best small molecule substrate for isozyme PAD1
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline methyl ester + NH3
-
-
-
?
N-alpha-benzoyl-L-arginine methyl ester + H2O
N-alpha-benzoyl-L-citrulline methyl ester + NH3
-
-
-
-
?
N-[(1R)-1-(biphenyl-3-yl)ethyl]-4-carbamimidamidobutanamide + H2O
N-[(1R)-1-([1,1''-biphenyl]-3-yl)ethyl]-4-(carbamoylamino)butanamide + NH3
-
-
-
?
N-[(1S)-1-(biphenyl-3-yl)ethyl]-4-carbamimidamidobutanamide + H2O
N-[(1S)-1-([1,1''-biphenyl]-3-yl)ethyl]-4-(carbamoylamino)butanamide + NH3
-
-
-
?
N-[(3'-bromobiphenyl-3-yl)methyl]-4-carbamimidamidobutanamide + H2O
N-[(3''-bromo[1,1''-biphenyl]-3-yl)methyl]-4-(carbamoylamino)butanamide + NH3
-
-
-
?
Nalpha-benzoyl L-arginine ethyl ester + H2O
Nalpha-benzoyl L-citrulline ethyl ester + NH3
-
-
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester
Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
-
?
Nalpha-benzoyl-L-arginine methyl ester + H2O
Nalpha-benzoyl-L-citrulline methyl ester + NH3
neuron-specific enolase 2 L-Arg + H2O
neuron-specific enolase 2 L-citrulline + NH3
-
-
-
?
neuron-specific-enolase1 + H2O
[neuron-specific]-enolase1 L-citrulline + NH3
-
-
-
-
?
PAD4-L-arginine + H2O
PAD4-L-citrulline + NH3
-
PAD4 is autodeiminated in a time-dependent manner
-
-
?
peptide H3-1-L-arginine + H2O
peptide H3-1-L-citrulline + NH3
i.e. Ac4KQTARKSTGG13
-
-
?
peptide H3-2-L-arginine + H2O
peptide H3-2-L-citrulline + NH3
i.e. Ac14KAPRKQLATK23
-
-
?
peptide H4-L-arginine + H2O
peptide H4-L-citrulline + NH3
-
i.e. Ac1SGRGKGGKGL10
-
?
peptidylprolyl isomerase A L-Arg + H2O
peptidylprolyl isomerase A L-citrulline + NH3
-
-
-
?
protamine + H2O
? + NH3
-
peptidyl arginine deiminase III shows highest activity towards
-
-
?
S100A3-L-arginine + H2O
S100A3-L-citrulline + NH3
-
-
-
?
t-butyloxycarbonyl-Leu-Arg-Arg-4-methylcoumarin-7-amide + H2O
? + NH3
-
-
-
-
?
t-butyloxycarbonyl-Leu-Gly-Arg-4-methylcoumarin-7-amide + H2O
t-butyloxycarbonyl-Leu-Gly-citrulline-4-methylcoumarin-7-amide + NH3
-
-
-
-
?
t-butyloxycarbonyl-Leu-Lys-Arg-4-methylcoumarin-7-amide + H2O
t-butyloxycarbonyl-Leu-Lys-citrulline-4-methylcoumarin-7-amide + NH3
-
-
-
-
?
t-butyloxycarbonyl-Leu-Thr-Arg-4-methylcoumarin-7-amide + H2O
t-butyloxycarbonyl-Leu-Thr-citrulline-4-methylcoumarin-7-amide + NH3
-
-
-
-
?
t-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumarin-7-amide + H2O
t-butyloxycarbonyl-Val-Pro-citrulline-4-methylcoumarin-7-amide + NH3
-
-
-
-
?
variant-specific surface protein L-arginine + H2O
variant-specific surface protein L-citrulline + NH3
-
-
-
-
?
voltage-dependent anion channel 1 L-Arg + H2O
voltage-dependent anion channel 1 L-citrulline + NH3
-
-
-
?
yeast enolase L-arginine + H2O
yeast enolase L-citrulline + NH3
-
-
-
-
?
[mitochondrial malate dehydrogenase 2]-L-arginine + H2O
[mitochondrial malate dehydrogenase 2]-L-citrulline + NH3
-
-
-
?
acetyl-L-Arg + H2O
acetyl-L-citrulline + NH3
peptidylarginine deiminase 1
-
-
?
acetyl-L-Arg methyl ester + H2O
acetyl-L-citrulline methyl ester + NH3
peptidylarginine deiminase 1
-
-
?
acetyl-L-Arg methyl ester + H2O
acetyl-L-citrulline methyl ester + NH3
peptidylarginine deiminase 2
-
-
?
acetyl-L-Arg methyl ester + H2O
acetyl-L-citrulline methyl ester + NH3
peptidylarginine deiminase 3
-
-
?
benzoyl-Arg ethyl ester + H2O
benzoyl-citrulline ethyl ester + NH3
-
-
-
-
?
benzoyl-Arg ethyl ester + H2O
benzoyl-citrulline ethyl ester + NH3
-
-
-
?
benzoyl-Arg ethyl ester + H2O
benzoyl-citrulline ethyl ester + NH3
-
peptidyl arginine deiminase II shows highest activity towards
-
-
?
benzoyl-Arg ethyl ester + H2O
benzoyl-citrulline ethyl ester + NH3
-
-
-
-
?
benzoyl-Arg ethyl ester + H2O
benzoyl-citrulline ethyl ester + NH3
-
-
-
-
?
benzoyl-Arg ethyl ester + H2O
benzoyl-citrulline ethyl ester + NH3
-
-
-
-
?
benzoyl-Arg-ethyl ester + H2O
benzoyl-citrulline-ethyl ester + NH3
-
hPADI2
-
-
?
benzoyl-Arg-ethyl ester + H2O
benzoyl-citrulline-ethyl ester + NH3
-
hPADI4
-
-
?
benzoyl-Arg-methyl ester + H2O
benzoyl-citrulline-methyl ester + NH3
-
hPADI2
-
-
?
benzoyl-Arg-methyl ester + H2O
benzoyl-citrulline-methyl ester + NH3
-
hPADI4
-
-
?
benzoyl-L-Arg + H2O
benzoyl-L-citrulline + NH3
peptidylarginine deiminase 1
-
-
?
benzoyl-L-Arg + H2O
benzoyl-L-citrulline + NH3
peptidylarginine deiminase 2
-
-
?
benzoyl-L-Arg + H2O
benzoyl-L-citrulline + NH3
peptidylarginine deiminase 3
-
-
?
benzoyl-L-Arg ethyl ester + H2O
benzoyl-L-citrulline ethyl ester + NH3
-
-
-
-
?
benzoyl-L-Arg ethyl ester + H2O
benzoyl-L-citrulline ethyl ester + NH3
peptidylarginine deiminase 1
-
-
?
benzoyl-L-Arg ethyl ester + H2O
benzoyl-L-citrulline ethyl ester + NH3
peptidylarginine deiminase 2
-
-
?
benzoyl-L-Arg ethyl ester + H2O
benzoyl-L-citrulline ethyl ester + NH3
peptidylarginine deiminase 3
-
-
?
benzoyl-L-Arg-NH2 + H2O
benzoyl-L-citrullineamide + NH3
-
peptidyl arginine deiminase I shows highest activity towards
-
-
?
benzoyl-L-arginine ethyl ester + H2O
benzoyl-L-citrulline ethyl ester + NH3
-
-
-
?
benzoyl-L-arginine ethyl ester + H2O
benzoyl-L-citrulline ethyl ester + NH3
-
-
-
?
Boc-Gln-Arg-Arg-7-amido-4-methylcoumarin + H2O
? + NH3
-
-
-
-
?
CESSSHHPGIAEFPS-R + H2O
CESSSHHPGIAEFPS-citrulline + NH3
i.e. fibrinogen peptide FibA-R
-
-
?
CESSSHHPGIAEFPS-R + H2O
CESSSHHPGIAEFPS-citrulline + NH3
i.e. fibrinogen peptide FibA-R
-
-
?
CXC chemokine ligand 10 L-Arg + H2O
CXC chemokine ligand 10 citrulline + NH3
-
-
-
-
?
CXC chemokine ligand 10 L-Arg + H2O
CXC chemokine ligand 10 citrulline + NH3
-
-
-
-
?
CXC chemokine ligand 11 L-arginine + H2O
CXC chemokine ligand 11 L-citrulline + NH3
-
-
-
-
?
CXC chemokine ligand 11 L-arginine + H2O
CXC chemokine ligand 11 L-citrulline + NH3
-
-
-
-
?
CXCL8 L-Arg + H2O
CXCL8 L-citrulline + NH3
citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation
-
-
?
CXCL8 L-Arg + H2O
CXCL8 L-citrulline + NH3
-
citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation
-
-
?
DSHKFDRDFIYSD + H2O
DSHKFDCitDFIYSD + NH3
79% conversion by isoform PAD4
-
-
?
DSHKFDRDFIYSD + H2O
DSHKFDCitDFIYSD + NH3
90% conversion by isoform PAD2
-
-
?
DSHKHSREWLWSD + H2O
DSHKHSCitEWLWSD + NH3
51% conversion by isoform PAD4
-
-
?
DSHKHSREWLWSD + H2O
DSHKHSCitEWLWSD + NH3
97% conversion by isoform PAD2
-
-
?
DSHKWHRDFFYSD + H2O
DSHKWHCitDFFYSD + NH3
73% conversion by isoform PAD4
-
-
?
DSHKWHRDFFYSD + H2O
DSHKWHCitDFFYSD + NH3
92% conversion by isoform PAD2
-
-
?
DSKFAFRGGIASD + H2O
DSKFAFCitGGIASD + NH3
25% conversion by isoform PAD4
-
-
?
DSKFAFRGGIASD + H2O
DSKFAFCitGGIASD + NH3
90% conversion by isoform PAD2
-
-
?
DSKFHFRYAVASD + H2O
DSKFHFCitYAVASD + NH3
92% conversion by isoform PAD2
-
-
?
DSKFHFRYAVASD + H2O
DSKFHFCitYAVASD + NH3
less than 20% conversion by isoform PAD4
-
-
?
DSKFKFRYAYASD + H2O
DSKFKFCitYAYASD + NH3
91% conversion by isoform PAD2
-
-
?
DSKFKFRYAYASD + H2O
DSKFKFCitYAYASD + NH3
less than 20% conversion by isoform PAD4
-
-
?
DSKHFHRDFIYSD + H2O
DSKHFHCitDFIYSD + NH3
69% conversion by isoform PAD4
-
-
?
DSKHFHRDFIYSD + H2O
DSKHFHCitDFIYSD + NH3
94% conversion by isoform PAD2
-
-
?
DSKHKSRDFVYSD + H2O
DSKHKSCitDFVYSD + NH3
69% conversion by isoform PAD4
-
-
?
DSKHKSRDFVYSD + H2O
DSKHKSCitDFVYSD + NH3
94% conversion by isoform PAD2
-
-
?
DSKHLSREWMWSD + H2O
DSKHLSCitEWMWSD + NH3
54% conversion by isoform PAD4
-
-
?
DSKHLSREWMWSD + H2O
DSKHLSCitEWMWSD + NH3
95% conversion by isoform PAD2
-
-
?
DSKKFDRDHLYSD + H2O
DSKKFDCitDHLYSD + NH3
77% conversion by isoform PAD4
-
-
?
DSKKFDRDHLYSD + H2O
DSKKFDCitDHLYSD + NH3
90% conversion by isoform PAD2
-
-
?
DSKKFDRGHLYSD + H2O
DSKKFDCitGHLYSD + NH3
80% conversion by isoform PAD4
-
-
?
DSKKFDRGHLYSD + H2O
DSKKFDCitGHLYSD + NH3
90% conversion by isoform PAD2
-
-
?
DSKKFHRDFLYSD + H2O
DSKKFHCitDFLYSD + NH3
64% conversion by isoform PAD4
-
-
?
DSKKFHRDFLYSD + H2O
DSKKFHCitDFLYSD + NH3
97% conversion by isoform PAD2
-
-
?
DSKKFHRGFLYSD + H2O
DSKKFHCitGFLYSD + NH3
100% conversion by isoform PAD2
-
-
?
DSKKFHRGFLYSD + H2O
DSKKFHCitGFLYSD + NH3
73% conversion by isoform PAD4
-
-
?
DSKKFKRDFLFSD + H2O
DSKKFKCitDFLFSD + NH3
35% conversion by isoform PAD4
-
-
?
DSKKFKRDFLFSD + H2O
DSKKFKCitDFLFSD + NH3
97% conversion by isoform PAD2
-
-
?
DSKKHDRDHLWSD + H2O
DSKKHDCitDHLWSD + NH3
80% conversion by isoform PAD4
-
-
?
DSKKHDRDHLWSD + H2O
DSKKHDCitDHLWSD + NH3
95% conversion by isoform PAD2
-
-
?
DSKKHFRDKLYSD + H2O
DSKKHFCitDKLYSD + NH3
37% conversion by isoform PAD4
-
-
?
DSKKHFRDKLYSD + H2O
DSKKHFCitDKLYSD + NH3
92% conversion by isoform PAD2
-
-
?
DSKKHFRGKLYSD + H2O
DSKKHFCitGKLYSD + NH3
22% conversion by isoform PAD4
-
-
?
DSKKHFRGKLYSD + H2O
DSKKHFCitGKLYSD + NH3
96% conversion by isoform PAD2
-
-
?
DSKKKHREWVWSD + H2O
DSKKKHCitEWVWSD + NH3
100% conversion by isoform PAD2
-
-
?
DSKKKHREWVWSD + H2O
DSKKKHCitEWVWSD + NH3
72% conversion by isoform PAD4
-
-
?
DSKKLHRDHMESD + H2O
DSKKLHCitDHMESD + NH3
65% conversion by isoform PAD4
-
-
?
DSKKLHRDHMESD + H2O
DSKKLHCitDHMESD + NH3
90% conversion by isoform PAD2
-
-
?
DSKKYDRDFLWSD + H2O
DSKKYDCitDFLWSD + NH3
76% conversion by isoform PAD4
-
-
?
DSKKYDRDFLWSD + H2O
DSKKYDCitDFLWSD + NH3
92% conversion by isoform PAD2
-
-
?
DSKKYDRGFLWSD + H2O
DSKKYDCitGFLWSD + NH3
81% conversion by isoform PAD4
-
-
?
DSKKYDRGFLWSD + H2O
DSKKYDCitGFLWSD + NH3
93% conversion by isoform PAD2
-
-
?
DSKWHHRDHLYSD + H2O
DSKWHHCitDHLYSD + NH3
71% conversion by isoform PAD4
-
-
?
DSKWHHRDHLYSD + H2O
DSKWHHCitDHLYSD + NH3
90% conversion by isoform PAD2
-
-
?
DSKWHHRGHLYSD + H2O
DSKWHHCitGHLYSD + NH3
71% conversion by isoform PAD4
-
-
?
DSKWHHRGHLYSD + H2O
DSKWHHCitGHLYSD + NH3
96% conversion by isoform PAD2
-
-
?
DSKWYHRNKFWSD + H2O
DSKWYHCitNKFWSD + NH3
45% conversion by isoform PAD4
-
-
?
DSKWYHRNKFWSD + H2O
DSKWYHCitNKFWSD + NH3
98% conversion by isoform PAD2
-
-
?
DSQFAFRGASASD + H2O
DSQFAFCitGASASD + NH3
less than 20% conversion by isoform PAD2
-
-
?
DSQFAFRGASASD + H2O
DSQFAFCitGASASD + NH3
less than 20% conversion by isoform PAD4
-
-
?
DSQWAFRHALFSD + H2O
DSQWAFCitHALFSD + NH3
95% conversion by isoform PAD2
-
-
?
DSQWAFRHALFSD + H2O
DSQWAFCitHALFSD + NH3
less than 20% conversion by isoform PAD4
-
-
?
FFDSHKFDRDFIYSD + H2O
FFDSHKFDCitDFIYSD + NH3
94% conversion by isoform PAD4
-
-
?
FFDSHKFDRDFIYSD + H2O
FFDSHKFDCitDFIYSD + NH3
97% conversion by isoform PAD2
-
-
?
FFDSHKHSREWLWSD + H2O
FFDSHKHSCitEWLWSD + NH3
22% conversion by isoform PAD4
-
-
?
FFDSHKHSREWLWSD + H2O
FFDSHKHSCitEWLWSD + NH3
96% conversion by isoform PAD2
-
-
?
FFDSHKKSREYVFSD + H2O
FFDSHKKSCitEYVFSD + NH3
100% conversion by isoform PAD2
-
-
?
FFDSHKKSREYVFSD + H2O
FFDSHKKSCitEYVFSD + NH3
58% conversion by isoform PAD4
-
-
?
FFDSHKLHREWMWSD + H2O
FFDSHKLHCitEWMWSD + NH3
91% conversion by isoform PAD4
-
-
?
FFDSHKLHREWMWSD + H2O
FFDSHKLHCitEWMWSD + NH3
92% conversion by isoform PAD2
-
-
?
FFDSHKWHRDFFYSD + H2O
FFDSHKWHCitDFFYSD + NH3
88% conversion by isoform PAD4
-
-
?
FFDSHKWHRDFFYSD + H2O
FFDSHKWHCitDFFYSD + NH3
9% conversion by isoform PAD2
-
-
?
FFDSKHFDREWIWSD + H2O
FFDSKHFDCitEWIWSD + NH3
89% conversion by isoform PAD4
-
-
?
FFDSKHFDREWIWSD + H2O
FFDSKHFDCitEWIWSD + NH3
94% conversion by isoform PAD2
-
-
?
FFDSKHKSRDFVYSD + H2O
FFDSKHKSCitDFVYSD + NH3
77% conversion by isoform PAD4
-
-
?
FFDSKHKSRDFVYSD + H2O
FFDSKHKSCitDFVYSD + NH3
92% conversion by isoform PAD2
-
-
?
FFDSKHLSREWMWSD + H2O
FFDSKHLSCitEWMWSD + NH3
73% conversion by isoform PAD4
-
-
?
FFDSKHLSREWMWSD + H2O
FFDSKHLSCitEWMWSD + NH3
97% conversion by isoform PAD2
-
-
?
FFDSKKFSRDHIESD + H2O
FFDSKKFSCitDHIESD + NH3
63% conversion by isoform PAD4
-
-
?
FFDSKKFSRDHIESD + H2O
FFDSKKFSCitDHIESD + NH3
90% conversion by isoform PAD2
-
-
?
FFDSKKKHREWVWSD + H2O
FFDSKKKHCitEWVWSD + NH3
76% conversion by isoform PAD4
-
-
?
FFDSKKKHREWVWSD + H2O
FFDSKKKHCitEWVWSD + NH3
99% conversion by isoform PAD2
-
-
?
FFDSKKWSREYFFSD + H2O
FFDSKKWSCitEYFFSD + NH3
76% conversion by isoform PAD4
-
-
?
FFDSKKWSREYFFSD + H2O
FFDSKKWSCitEYFFSD + NH3
94% conversion by isoform PAD2
-
-
?
fibrin L-arginine + H2O
fibrin L-citrulline + NH3
-
citrullinated fibrin is a potential antigen of rheumatoid arthritis
-
-
?
fibrinogen-L-arginine + H2O
fibrinogen-L-citrulline + NH3
PAD4, involvement in rheumatoid arthritis
-
-
ir
fibrinogen-L-arginine + H2O
fibrinogen-L-citrulline + NH3
PAD4
-
-
ir
filaggrin + H2O
? + NH3
-
deimination of protein-bound Arg residues to citrulline, the substrate has little structural order, the reaction proceeds rapidly to about 95% completion und results in loss of the organized structure
-
-
?
filaggrin L-arginine + H2O
filaggrin L-citrulline + NH3
isoform PAD1
-
-
?
filaggrin L-arginine + H2O
filaggrin L-citrulline + NH3
isoform PAD3
-
-
?
filaggrin L-arginine + H2O
filaggrin L-citrulline + NH3
peptidylarginine deiminase 1
-
-
?
filaggrin L-arginine + H2O
filaggrin L-citrulline + NH3
peptidylarginine deiminase 2
-
-
?
filaggrin L-arginine + H2O
filaggrin L-citrulline + NH3
peptidylarginine deiminase 3
-
-
?
filaggrin-L-arginine + H2O
filaggrin-L-citrulline + NH3
PAD4, involvement in rheumatoid arthritis
-
-
ir
filaggrin-L-arginine + H2O
filaggrin-L-citrulline + NH3
PAD4
-
-
ir
glial fibrillary acidic protein-L-arginine + H2O
glial fibrillary acidic protein-L-citrulline + NH3
PAD2, involvement in Alzheimer's diease
-
-
ir
glial fibrillary acidic protein-L-arginine + H2O
glial fibrillary acidic protein-L-citrulline + NH3
PAD2
-
-
ir
Gly-Gly-L-Arg + H2O
Gly-Gly-L-Cit + NH3
-
88% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
Gly-Gly-L-Arg + H2O
Gly-Gly-L-Cit + NH3
-
88% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
Gly-L-Arg + H2O
Gly-L-Cit + NH3
-
130% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
Gly-L-Arg + H2O
Gly-L-Cit + NH3
-
130% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
histone H2A-L-arginine + H2O
histone H2A-L-citrulline + NH3
PAD4, involvement in rheumatoid arthritis
-
-
ir
histone H2A-L-arginine + H2O
histone H2A-L-citrulline + NH3
PAD4
-
-
ir
histone H3-L-Arg + H2O
histone H3-L-citrulline
-
PADI4 is a histone H3-specific arginine deiminase. Deimination is a mechanism for antagonizing the transcriptional induction mediated by arginine methylation
-
-
?
histone H3-L-Arg + H2O
histone H3-L-citrulline
-
PADI4 is a histone H3-specific arginine deiminase
-
-
?
histone H3-L-arginine + H2O
histone H3-L-citrulline + NH3
PAD4, involvement in rheumatoid arthritis
-
-
ir
histone H3-L-arginine + H2O
histone H3-L-citrulline + NH3
PAD4
-
-
ir
histone H3-L-arginine + H2O
histone H3-L-citrulline + NH3
PAD4 interacts with p53 and is recruited to the p21 promoter to regulate histone H3 L-Arg methylation and citrullination
-
-
?
histone H4-L-arginine + H2O
histone H4-L-citrulline + NH3
PAD4, involvement in rheumatoid arthritis
-
-
ir
histone H4-L-arginine + H2O
histone H4-L-citrulline + NH3
PAD4
-
-
ir
histone H4-L-arginine + H2O
histone H4-L-citrulline + NH3
-
isozyme PAD4 deiminates histone H4 at arginines 3, 17, and 19 in vitro and arginine 3 in vivo
-
-
?
histone L-arginine + H2O
histone L-citrulline + NH3
-
PAD4 mediates gene expression by regulating Arg methylation and citrullination in histones
-
-
?
IHAREIFDSR + H2O
IHAREIFDS-citrulline + NH3
peptide derived from enolase
-
-
?
IHAREIFDSR + H2O
IHAREIFDS-citrulline + NH3
-
peptide derived from enolase
-
-
?
IHAREIFDSR + H2O
IHAREIFDS-citrulline + NH3
peptide derived from enolase
-
-
?
keratin + H2O
? + NH3
-
peptidylarginine deiminase type I acts on the arginine residue in the V2 subdomain of mouse keratin more readily than peptidylarginine deiminase type II
-
-
?
keratin L-arginine + H2O
keratin L-citrulline + NH3
peptidylarginine deiminase 1
-
-
?
keratin L-arginine + H2O
keratin L-citrulline + NH3
peptidylarginine deiminase 2
-
-
?
keratin L-arginine + H2O
keratin L-citrulline + NH3
peptidylarginine deiminase 3
-
-
?
keratin-L-arginine + H2O
keratin-L-citrulline + NH3
PAD2, involvement in psoriasis
-
-
ir
keratin-L-arginine + H2O
keratin-L-citrulline + NH3
PAD2
-
-
ir
L-arginine + H2O
L-citrulline + NH3
-
28% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
L-arginine + H2O
L-citrulline + NH3
-
28% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
L-arginine-methyl ester + H2O
L-citrulline methyl ester + NH3
isoform PAD1 shows 15% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
L-arginine-methyl ester + H2O
L-citrulline methyl ester + NH3
isoform PAD3 shows 15% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
myelin basic protein + H2O
?
-
decreased methylation of myelin basic protein possibly by a shortage of S-adenosylmethionine or downregulation of the methyltransferase gen expression allows the peptidylarginine deiminase greater access to the arginyl groups of myelin basic protein
-
-
?
myelin basic protein L-arginine + H2O
myelin basic protein L-citrulline + NH3
-
-
-
-
?
myelin basic protein L-arginine + H2O
myelin basic protein L-citrulline + NH3
-
-
-
?
myelin basic protein L-arginine + H2O
myelin basic protein L-citrulline + NH3
PAD2 overexpression in brain of transgenic mice leads to myelin loss in the central nervous system
-
-
?
myelin basic protein L-arginine + H2O
myelin basic protein L-citrulline + NH3
-
-
-
?
myelin basic protein-L-arginine + H2O
myelin basic protein-L-citrulline + NH3
-
PAD2 and PAD4 are involved in the pathogenesis of demyelination diseases such as multiple sclerosis, overview
-
-
?
myelin basic protein-L-arginine + H2O
myelin basic protein-L-citrulline + NH3
PAD2, involvement in multiple sclerosis
-
-
ir
myelin basic protein-L-arginine + H2O
myelin basic protein-L-citrulline + NH3
-
amino acid sequence determination of the substrate protein by LC/MS, PAD2 deiminates 18 of 19 arginyl residues, whereas PAD4 deiminates 14 of 19 arginyl residues, determination of deimination residues, overview
-
-
?
myelin basic protein-L-arginine + H2O
myelin basic protein-L-citrulline + NH3
PAD2
-
-
ir
myelin basic protein-L-arginine + H2O
myelin basic protein-L-citrulline + NH3
-
-
-
?
myelin basic protein-L-arginine + H2O
myelin basic protein-L-citrulline + NH3
-
-
-
?
N-acetyl-L-arginine + H2O
N-acetyl-L-citrulline ethyl ester + NH3
isoform PAD1 shows 160% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
N-acetyl-L-arginine + H2O
N-acetyl-L-citrulline ethyl ester + NH3
isoform PAD3 shows 135% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
N-acetyl-L-arginine-methyl ester + H2O
N-acetyl-L-citrulline-methyl ester + NH3
isoform PAD1 shows 80% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
N-acetyl-L-arginine-methyl ester + H2O
N-acetyl-L-citrulline-methyl ester + NH3
isoform PAD3 shows 125% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
N-alpha-benzoyl-L-arginine + H2O
N-alpha-benzoyl-L-citrulline + NH3
-
-
-
-
?
N-alpha-benzoyl-L-arginine + H2O
N-alpha-benzoyl-L-citrulline + NH3
-
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
Mus musculus C57BL/6 / 129S
-
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
-
?
Nalpha-benzoyl-L-arginine + H2O
Nalpha-benzoyl-L-citrulline + NH3
isoform PAD1 shows 120% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
Nalpha-benzoyl-L-arginine + H2O
Nalpha-benzoyl-L-citrulline + NH3
isoform PAD3 shows 70% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
Nalpha-benzoyl-L-arginine + H2O
Nalpha-benzoyl-L-citrulline + NH3
-
-
-
?
Nalpha-benzoyl-L-arginine + H2O
Nalpha-benzoyl-L-citrulline + NH3
-
-
-
?
Nalpha-benzoyl-L-arginine amide + H2O
Nalpha-benzoyl-L-citrulline amide + NH3
-
-
-
?
Nalpha-benzoyl-L-arginine amide + H2O
Nalpha-benzoyl-L-citrulline amide + NH3
-
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
Nalpha-benzoyl-L-citrulline ethyl ester + NH3
100% activity
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
Nalpha-benzoyl-L-citrulline ethyl ester + NH3
100% activity
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
Nalpha-benzoyl-L-citrulline ethyl ester + NH3
100% activity
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
-
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
100% activity
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
100% activity
-
-
?
Nalpha-benzoyl-L-arginine methyl ester + H2O
Nalpha-benzoyl-L-citrulline methyl ester + NH3
-
-
-
?
Nalpha-benzoyl-L-arginine methyl ester + H2O
Nalpha-benzoyl-L-citrulline methyl ester + NH3
-
-
-
?
Nalpha-benzoyl-L-arginine-amide + H2O
Nalpha-benzoyl-L-citrulline-amide + NH3
isoform PAD1 shows 110% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
Nalpha-benzoyl-L-arginine-amide + H2O
Nalpha-benzoyl-L-citrulline-amide + NH3
isoform PAD3 shows 105% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
Nalpha-tosyl-L-arginine-methyl ester + H2O
Nalpha-tosyl-L-citrulline-methyl ester + NH3
isoform PAD1 shows 20% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
Nalpha-tosyl-L-arginine-methyl ester + H2O
Nalpha-tosyl-L-citrulline-methyl ester + NH3
isoform PAD3 shows 22% activity compared to Nalpha-benzoyl-L-arginine ethyl ester
-
-
?
PPGFSPFR + H2O
PPGFSPF-citrulline + NH3
peptide derived from bradykinin
-
-
?
PPGFSPFR + H2O
PPGFSPF-citrulline + NH3
-
peptide derived from bradykinin
-
-
?
PPGFSPFR + H2O
PPGFSPF-citrulline + NH3
peptide derived from bradykinin
-
-
?
protein L-Arg + H2O
?
-
C-1, the most unmodified of the components of myelin basic protein, is an excellent substrate for the enzyme, thereby confirming that the origin of the citrulline in myelin basic protein arises by the action of this enzyme
-
-
?
protein L-Arg + H2O
?
-
expression of the enzyme in luminal and glandular epithelia of the uterus is controlled by amount of the steroid hormones estrogen and progesterone
-
-
?
protein L-Arg + H2O
?
-
the ureido group on the citrulline formed by the peptidylarginine deiminase modification functions to unfold proteins due to decrease in net charge, loss of potential ionic bonds, and interference with H bonds
-
-
?
protein L-Arg + H2O
?
-
peptidylarginine deiminase, acting in concert with arginine-specific proteinases from Porphyromonas gingivalis, promotes the growth of the pathogen in the periodontal pocket, initially by enhancing its survivability and then by assisting the organism in its circumvention of host humoral defenses
-
-
?
protein L-Arg + H2O
?
-
all-trans retinoic acid increases peptidylarginine deiminase activity in a newborn rat keratinocyte cell line
-
-
?
protein L-Arg + H2O
?
-
citrullyl residues in the membranous protein of horny cells of the epidermis of newborn rat are formed by the action of epidermal peptidylarginine deiminase
-
-
?
protein L-Arg + H2O
protein L-citrulline + NH3
-
bovine S-carboxymethylated prekeratin and myelin
-
-
?
protein L-Arg + H2O
protein L-citrulline + NH3
peptidyl deiminase type II is the primary enzyme responsible for the conversion of protein bound arginine to citrulline in the central nervous system
-
-
?
protein L-Arg + H2O
protein L-citrulline + NH3
-
[NV]-angiotensin II, fibronectin fragment, LHRH, chicken brain peptide, molluscan cardioexxitatory neuropeptide, bradykinin potentiator B, dynorphin A, [VA]-kemptide, neurotensin, bradykinin, K-bradykinin, MK-bradykinin, Y-bradykinin
-
-
?
protein L-Arg + H2O
protein L-citrulline + NH3
-
PAD catalyzes the deimination of the guanidino group from peptidylarginine residues of various peptides to produce peptidylcitrulline and ammonia
-
-
?
protein L-arginine + H2O
protein L-citrulline + NH3
-
-
-
?
protein L-arginine + H2O
protein L-citrulline + NH3
-
-
-
?
protein-L-arginine + H2O
protein-L-citrulline + NH3
citrullination of proteins may exert a specific role in the course of PNS development and repair
-
-
?
protein-L-arginine + H2O
protein-L-citrulline + NH3
PAD1
-
-
ir
protein-L-arginine + H2O
protein-L-citrulline + NH3
PAD4 is a transcriptional coregulator that catalyzes the calcium-dependent conversion of specific arginine residues in proteins to citrulline and plays a role in the onset and progression of the chronic autoimmune disorder rheumatoid arthritis
-
-
?
protein-L-arginine + H2O
protein-L-citrulline + NH3
-
posttranslational convertion, PADI4 plays an essential role in immune cell differentiation and apoptosis, ionomycin-inducible PADI4-decreased cell viability and PADI4-enhanced apoptosis, overview
-
-
?
protein-L-arginine + H2O
protein-L-citrulline + NH3
development and evaluation of a highly sensitive antibody-based assay method for PAD activity determination, overview
-
-
?
protein-L-arginine + H2O
protein-L-citrulline + NH3
-
development and evaluation of a highly sensitive antibody-based assay method for PAD activity determination, overview
-
-
?
protein-L-arginine + H2O
protein-L-citrulline + NH3
Mus musculus C57BL/6 / 129S
-
development and evaluation of a highly sensitive antibody-based assay method for PAD activity determination, overview
-
-
?
protein-L-arginine + H2O
protein-L-citrulline + NH3
-
development and evaluation of a highly sensitive antibody-based assay method for PAD activity determination, overview
-
-
?
protein-L-arginine + H2O
protein-L-citrulline + NH3
-
-
-
ir
protein-L-arginine + H2O
protein-L-citrulline + NH3
-
citrullination of proteins may exert a specific role in the course of PNS development and repair
-
-
?
trichohyalin + H2O
? + NH3
-
deimination of protein-bound Arg residues to citrulline, the substrate has a highly alpha-helical structure, the reaction proceeds slowly to about 25% and can be forced to a maximum of about 65%
-
-
?
trichohyalin-L-arginine + H2O
trichohyalin-L-citrulline + NH3
PAD3, involvement in skin disease
-
-
ir
trichohyalin-L-arginine + H2O
trichohyalin-L-citrulline + NH3
PAD3
-
-
ir
vimentin-L-arginine + H2O
vimentin-L-citrulline + NH3
PAD2, involvement in Alzheimer's disease
-
-
ir
vimentin-L-arginine + H2O
vimentin-L-citrulline + NH3
PAD2
-
-
ir
vimetin L-arginine + H2O
vimentin L-citrulline + NH3
peptidylarginine deiminase 2
-
-
?
vimetin L-arginine + H2O
vimentin L-citrulline + NH3
peptidylarginine deiminase 4
-
-
?
additional information
?
-
-
PAD II not only binds with the beta-amyloid peptides Abeta1-40, Abeta22-35, Abeta17-28,Abeta25-35 and Abeta32-35 but assists in the proteolytic degradation of these peptides with the concomitant formation of insoluble fibrils
-
-
?
additional information
?
-
-
abnormal accumulation of citrullinated proteins and abnormal activation of PAD2 in hippocampi of patients with Alzheimer's disease, strongly suggests that peptidylarginine deiminase has an important role in the onset and progression of abnormal accumulation of citrullinated proteins and abnormal activation of PAD2 in hippocampi of Alzheimer's disease
-
-
?
additional information
?
-
peptidylarginine deiminase type 4 plays an essential role in pathogenesis of rheumatoid arthritis.Peptidylarginine deiminase type 4 may contribute to the disrupted apoptosis of tumors by caspase-mediated claevage of cytokeratin
-
-
?
additional information
?
-
-
the enzyme catalyzes post-translational modification of protein through the conversion of arginine to citrulline in the presence of calcium ions. Peptidylarginine deiminase-mediated deimination of epithelial cell keratin resulting in cytoskeletal remodeling suggests a possible role for hPADVI in cytoskeletal reorganization in the egg and in early embryo development
-
-
?
additional information
?
-
methylated Arg residues are quite poor substrates for full-length PAD4 in vitro, regardless of whether this residue is in the context of a small molecule or a peptide substrate
-
-
?
additional information
?
-
-
methylated Arg residues are quite poor substrates for full-length PAD4 in vitro, regardless of whether this residue is in the context of a small molecule or a peptide substrate
-
-
?
additional information
?
-
PADI3 expression is driven by Sp1/Sp3 and NF-Y binding to the promoter region
-
-
?
additional information
?
-
-
PADI3 expression is driven by Sp1/Sp3 and NF-Y binding to the promoter region
-
-
?
additional information
?
-
-
the enzyme is involved in autoimmune rheumatoid arthritis
-
-
?
additional information
?
-
the enzyme is involved in autoimmune rheumatoid arthritis
-
-
?
additional information
?
-
the enzyme is involved in autoimmune rheumatoid arthritis
-
-
?
additional information
?
-
the enzyme is involved in autoimmune rheumatoid arthritis
-
-
?
additional information
?
-
the enzyme is involved in autoimmune rheumatoid arthritis
-
-
?
additional information
?
-
-
the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma
-
-
?
additional information
?
-
the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma
-
-
?
additional information
?
-
the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma
-
-
?
additional information
?
-
the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma
-
-
?
additional information
?
-
the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma
-
-
?
additional information
?
-
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, e.g. PAD2 in glaucoma of the optic nerve, overview
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, e.g. PAD2 in glaucoma of the optic nerve, overview
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, e.g. PAD2 in glaucoma of the optic nerve, overview
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, e.g. PAD2 in glaucoma of the optic nerve, overview
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, e.g. PAD2 in glaucoma of the optic nerve, overview
-
-
?
additional information
?
-
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, overview
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, overview
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, overview
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, overview
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, overview
-
-
?
additional information
?
-
-
substrate binding structure, sequence specificity, overview
-
-
?
additional information
?
-
substrate binding structure, sequence specificity, overview
-
-
?
additional information
?
-
-
a methylated lysine residue flanking the targeted arginine influences PAD-4-mediated deimination
-
-
?
additional information
?
-
-
no activity toward PVRAK, DQRTA, DVRIA, and EPRLF
-
-
?
additional information
?
-
-
the binding affinity of autodeiminated PAD4 for p53 and H3 are similar to non-deiminated PAD4. In contrast, the affinity of autodeiminated PAD4 for HDAC1, PRMT1, and Cit H3 is reduced by 3.7, 4.5, and 10fold, respectively. Results suggest that the autodeimination of PAD4 in vivo could affect its functional activity by regulating its ability to interact with binding partners
-
-
?
additional information
?
-
-
possible 14-3-3 protein binding sites in human PAD6 are identified by in silico methods. Two of these sites are confirmed as 14-3-3 binding sites by fluorescence polarization competition and X-ray crystallography
-
-
?
additional information
?
-
nearly no activity with free L-arginine, L-agmatine, histone H3, and histone H4
-
-
?
additional information
?
-
isoform PAD2 appears to favor citrullination of glycine-containing motifs. Distinct hydrophobic motifs are identified for PAD2 citrullination sites predicted to reside within alpha-helical and beta-sheet regions. There is potential substrate overlap between coil region citrullination and arginine methylation
-
-
?
additional information
?
-
isoform PAD2 appears to favor citrullination of glycine-containing motifs. Distinct hydrophobic motifs are identified for PAD2 citrullination sites predicted to reside within alpha-helical and beta-sheet regions. There is potential substrate overlap between coil region citrullination and arginine methylation
-
-
?
additional information
?
-
-
isoform PAD2 appears to favor citrullination of glycine-containing motifs. Distinct hydrophobic motifs are identified for PAD2 citrullination sites predicted to reside within alpha-helical and beta-sheet regions. There is potential substrate overlap between coil region citrullination and arginine methylation
-
-
?
additional information
?
-
isoform PAD4 appears to favor citrullination of glycine-containing motifs. There is potential substrate overlap between coil region citrullination and arginine methylation
-
-
?
additional information
?
-
isoform PAD4 appears to favor citrullination of glycine-containing motifs. There is potential substrate overlap between coil region citrullination and arginine methylation
-
-
?
additional information
?
-
-
isoform PAD4 appears to favor citrullination of glycine-containing motifs. There is potential substrate overlap between coil region citrullination and arginine methylation
-
-
?
additional information
?
-
proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis. Pressure-induced translational control of PAD2 expression is consistent with a possible role for PAD2 and citrullination in primary open-angle glaucoma
-
-
?
additional information
?
-
-
proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis. Pressure-induced translational control of PAD2 expression is consistent with a possible role for PAD2 and citrullination in primary open-angle glaucoma
-
-
?
additional information
?
-
the cortical granule enzyme plays a role in preimplantation embryonic development
-
-
?
additional information
?
-
-
the cortical granule enzyme plays a role in preimplantation embryonic development
-
-
?
additional information
?
-
PAD 6 is essential for oocyte cytoskeletal sheet formation and female fertility, it plays an important role in germ-cell-specific structures in zygote/embryo development, citrullination is a regulator of fertility, overview
-
-
?
additional information
?
-
-
IKKgamma and PAD2 can coimmunoprecipitate in the presence of the Ca2+ ionophore
-
-
?
additional information
?
-
-
does not citrullinate interleukin-1beta
-
-
?
additional information
?
-
-
the enzyme undergoes automodification
-
-
?
additional information
?
-
no substrate: peptide GFSPFRSS
-
-
?
additional information
?
-
no substrates: peptides Arg-Gly-Glu, Met-Arg-Phe, fibrinogen peptide CESSSHHPGIAEFPS-R-GK
-
-
?
additional information
?
-
-
no substrates: peptides Arg-Gly-Glu, Met-Arg-Phe, fibrinogen peptide CESSSHHPGIAEFPS-R-GK
-
-
?
additional information
?
-
-
no substrate: peptide GFSPFRSS
-
-
?
additional information
?
-
no substrate: peptide GFSPFRSS
-
-
?
additional information
?
-
no substrates: peptides Arg-Gly-Glu, Met-Arg-Phe, fibrinogen peptide CESSSHHPGIAEFPS-R-GK
-
-
?
additional information
?
-
-
PAD2 is involved in some processes of neurodegeneration and myelination in the central nervous system
-
-
?
additional information
?
-
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6
-
-
?
additional information
?
-
no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6
-
-
?
