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3.5.3.15: protein-arginine deiminase

This is an abbreviated version!
For detailed information about protein-arginine deiminase, go to the full flat file.

Word Map on EC 3.5.3.15

Reaction

protein L-arginine
+
H2O
=
protein L-citrulline
 +
NH3

Synonyms

deiminase, protein (arginine), HL-60 PAD, hPADI2, hPADI4, hPADVI, PAD, PAD 1, PAD 2, PAD 3, PAD 4, PAD II, PAD IV, PAD type 2, PAD-4, PAD-H19, PAD-R11, PAD-R4, PAD1, PAD2, PAD3, PAD4, PAD6, PADI1, Padi2, PADI3, PADI4, peptidyl arginine deiminas 4, peptidyl arginine deiminase, peptidyl arginine deiminase 2, peptidyl-arginine deiminase, peptidylarginine deiminase, peptidylarginine deiminase 1, peptidylarginine deiminase 2, peptidylarginine deiminase 3, peptidylarginine deiminase 4, peptidylarginine deiminase 6, peptidylarginine deiminase isoform VI, peptidylarginine deiminase IV, peptidylarginine deiminase type 4, Peptidylarginine deiminase type alpha, peptidylarginine deiminase type I, peptidylarginine deiminase type II, peptidylarginine deiminase type III, peptidylarginine deiminase type VI, peptidylarginine deiminase-4, PPAD, protein arginine deiminase, protein arginine deiminase 2, protein arginine deiminase 3, protein arginine deiminase 4

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.3 In linear amidines
                3.5.3.15 protein-arginine deiminase

Source Tissue

Source Tissue on EC 3.5.3.15 - protein-arginine deiminase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
strong expression by adenocarconoma from colon, gall bladder, lung, pancreas, thyroid, uterus, prostate, stomach, parotid, rectum, ovary, esophagus and duodenum, strong expression. Moderate expression by adenocarcinoma from small intestine
Manually annotated by BRENDA team
thyroid, moderate expression
Manually annotated by BRENDA team
brain, moderate expression
Manually annotated by BRENDA team
-
PADI4 is significantly overexpressed in blood of rheumatoid arthritis. Genetic variation within PADI4 is not a major risk factor for rheumatoid arzhritis in Caucasians
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
male and female, unique expression of PAD6
Manually annotated by BRENDA team
low expression level of PAD1
Manually annotated by BRENDA team
strong expression
Manually annotated by BRENDA team
-
T-cell leukemia cell line with tetracycline resistance
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
-
in adult mainly expressed in ovary and peripheral blood leukocytes
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
-
mammary alveolar luminal epithelial cell
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
peptidylarginine deiminase type 4 is initially expressed in CD34+ cells of bone marrow and then distributed in derives of the multi-potent progenitor cells in diverse tissues
Manually annotated by BRENDA team
-
embryonal, in the prospective medulla
Manually annotated by BRENDA team
strong expression
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
expression of isoform PAD2
Manually annotated by BRENDA team
-
high abundance of PADI14 in the synovial membrane is a prominent feature of rheumatoid arthritis
Manually annotated by BRENDA team
-
slight expression
Manually annotated by BRENDA team
moderate expression
Manually annotated by BRENDA team
-
slight expression
Manually annotated by BRENDA team
-
the level of the enzyme in theses cells decreases as the cells differentiate
Manually annotated by BRENDA team
additional information