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strong expression by adenocarconoma from colon, gall bladder, lung, pancreas, thyroid, uterus, prostate, stomach, parotid, rectum, ovary, esophagus and duodenum, strong expression. Moderate expression by adenocarcinoma from small intestine
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thyroid, moderate expression
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brain, moderate expression
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moderate expression
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PADI4 is significantly overexpressed in blood of rheumatoid arthritis. Genetic variation within PADI4 is not a major risk factor for rheumatoid arzhritis in Caucasians
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moderate expression
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moderate expression
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strong expression
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male and female, unique expression of PAD6
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low expression level of PAD1
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strong expression
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T-cell leukemia cell line with tetracycline resistance
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moderate expression
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in adult mainly expressed in ovary and peripheral blood leukocytes
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strong expression
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moderate expression
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mammary alveolar luminal epithelial cell
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CMT-25 cell
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moderate expression
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peptidylarginine deiminase type 4 is initially expressed in CD34+ cells of bone marrow and then distributed in derives of the multi-potent progenitor cells in diverse tissues
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embryonal, in the prospective medulla
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strong expression
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moderate expression
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strong expression
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PPAD6
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expression of isoform PAD2
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high abundance of PADI14 in the synovial membrane is a prominent feature of rheumatoid arthritis
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slight expression
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moderate expression
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slight expression
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the level of the enzyme in theses cells decreases as the cells differentiate
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cortical
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pressure-treated astrocytes exhibit elevated PAD2 and citrullination without apparent change in PAD2 mRNA
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PAD2 immunoreactivity is increased in Scrapie-infected brains, with staining detected primarily in reactive astrocytes
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cortical
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fetal
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abnormal accumulation of citrullinated proteins and abnormal activation of PAD2 in hippocampi of patients with Alzheimer's disease
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of healthy persons and of multiple sclerosis patients
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low activity
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much of the enzyme is localized to myelin
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expression levels of PAD2 protein as well as its enzyme activity are significantly increased in brain sections of Scrapie-infected mice, including hippocampus, brain stem, and striatum
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low activity
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high amount of PAD2
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in Purkinje cells of the cerebellum
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in neuronal cells of the cerebral cortex
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embryonal, isozyme expression analysis, PAD2 expression occurs also in 19- to 21-day-old embryos at a developmental stage well before myelination begins, overview
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high amount of PAD2
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PAD6
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expression of isoform PAD3 is restricted to granular layer and lower stratum corneum
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isoform PAD1 is detected in all layers of the epidermis, including the stratum corneum
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peptidylarginine deiminase 1
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peptidylarginine deiminase 2
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peptidylarginine deiminase 3
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isozyme PAD1
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isoform PAD2 is mainly detected in both the spinous and granular layers with a more intense staining of the latter
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isoform PAD3 expression is restricted to the granular layer and lower stratum corneum
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PAD1 is detected in the entire epidermis with an increasing intensity gradient from the basal to the granular layer
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peptidyl arginine deiminase I and III
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anagen hair follicle, PAD1 is present in non-cornified Huxley layer, cornified Huxley layer, non-cornified inner root sheath cuticle, companion layer and arrector pili muscles
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anagen hair follicle, PAD2 is present in arrector pili muscles
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anagen hair follicle, PAD3 is present in non-cornified Henle layer, non-cornified Huxley layer, non-cornified inner root sheath cuticle and medulla
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inner root sheath and cuticle of the hair follicles
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peptidyl arginine deiminase III
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abnormal accumulation of citrullinated proteins and abnormal activation of PAD2 in hippocampi of patients with Alzheimer's disease
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embryonal, in the prospective dentate gyrus, microglial marker-negative cells show expression of PAD isozyme 2, but not of isozymes PAD1,3, and 4, overview
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expression of isoform PAD2 in all layers of living keratinocytes with a gradient of expression increasing from the basal (very low detection) to the granular layer, where the protein is located at the cell periphery
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normal epidermal keratinocyte
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epidermal, isozyme PAD1, PAD1 and MFZ1 increase both during differentiation
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low activity
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low activity
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slight expression
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slight expression
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low activity
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low activity
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low activity
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peptidylarginine deiminase 2, cell from patients with rheumatoid arthitis and healthy controls show identical expression patterns
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peritoneal
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peritoneal
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isoform PAD3
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peptidylarginine deiminase 2, cell from patients with rheumatoid arthitis and healthy controls show identical expression patterns
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peptidylarginine deiminase 4, cell from patients with rheumatoid arthitis and healthy controls show identical expression patterns
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high activity
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skeletal muscle
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skeletal muscle
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quantitative determination of PAD2 and PAD4 by immunohistochemistry
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fetal, increased amounts of PAD3
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juvenile, increased amounts of PAD3
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PAD4 is primarily expressed in neutrophils
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PAD2
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PAD2
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cortical granules of unfertilized oocytes
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PAD6
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Pad6 mRNA expression is localized to oocytes from primordial through antral follicles, but excluded from granulosa cells, theca cells, and corpora lutea
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glaucomatous
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glaucomatous, increased expression of PAD2
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from older, glaucomatous DBA/2J mice (primary open-angle glaucoma), but not in younger DGB/2J or control C57BL6J mice
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in adult mainly expressed in ovary and peripheral blood leukocytes
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Pad6 mRNA is detected preferentially in adult ovaries
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majority of PAD2 staining in immature cell stages, overview
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majority of PAD2 staining in immature cell stages, overview
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fetal
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fetal, increased amounts of PAD2
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juvenile, increased amounts of PAD2
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slight expression
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PAD2 and PAD4
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low activity
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low activity
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isoform PAD1
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isoform PAD3 is expressed in granular level of stratum corneum
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PAD1 is present in secretory cells and myoepithelial cells
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PAD2 is present in secretory cells and myoepithelial cells
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hPADI2
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hPADI4
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ovariectomized, amount of the enzyme in the uterus is considerably diminished by ovariectomy, the expression of the enzyme in luminal andd glandular epithelia is controlled by the amount of the steroid hormones estrogen and progesterone
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peptidyl arginine deiminase I
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additional information
isoform PAD2 protein is not detected in lung, heart, liver, granular stomach, and gizzard
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additional information
isoform PAD2 protein is not detected in lung, heart, liver, granular stomach, and gizzard
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additional information
isoform PAD2 protein is not detected in lung, heart, liver, granular stomach, and gizzard
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additional information
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isoform PAD2 protein is not detected in lung, heart, liver, granular stomach, and gizzard
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additional information
no activity in macrophages
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additional information
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no activity in macrophages
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additional information
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PAD1 is not detected in sebaceous gland
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additional information
PAD1 is not detected in sebaceous gland
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additional information
PAD1 is not detected in sebaceous gland
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additional information
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PAD2 is not detected in sebaceous gland
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additional information
PAD2 is not detected in sebaceous gland
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additional information
PAD2 is not detected in sebaceous gland
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additional information
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PAD3 is not detected in sebaceous gland and sweat gland
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additional information
PAD3 is not detected in sebaceous gland and sweat gland
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additional information
PAD3 is not detected in sebaceous gland and sweat gland
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additional information
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PAD tissue expression pattern, overview
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additional information
PAD tissue expression pattern, overview
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additional information
PAD tissue expression pattern, overview
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additional information
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PAD is not detected in gallbladder and appendix
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additional information
PAD2 is expressed in most tissues and cell types
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additional information
PAD2 is expressed in most tissues and cell types
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additional information
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PAD2 is expressed in most tissues and cell types
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additional information
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tissue distribution, no activity in testis and liver, overview
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additional information
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no activity detected in spleen, stomach, small intestine, large intestine, pancreas, serum and heart
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additional information
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PAD tissue expression pattern, overview
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