3.5.3.15: protein-arginine deiminase
This is an abbreviated version!
For detailed information about protein-arginine deiminase, go to the full flat file.
Word Map on EC 3.5.3.15
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3.5.3.15
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citrullination
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rheumatoid
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arthritis
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histone
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autoimmune
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deimination
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autoantibody
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anti-citrullinated
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chromatin
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acpas
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epitope
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synovial
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padis
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porphyromonas
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anti-ccp
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netosis
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periodontitis
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gingivalis
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sclerosis
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fibrinogen
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anti-cyclic
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vimentin
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hla-drb1
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elastase
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autoantigens
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ptpn22
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decondensation
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cl-amidine
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lupus
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erythematosus
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myeloperoxidase
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pharmacology
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self-antigens
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ra-associated
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gingipains
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synoviocytes
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rheumatology
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medicine
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arginyl
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erosive
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analysis
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drug development
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fibrin
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non-hla
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filaggrin
- 3.5.3.15
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citrullination
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rheumatoid
- arthritis
- histone
- autoimmune
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deimination
- autoantibody
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anti-citrullinated
- chromatin
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acpas
- epitope
- synovial
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padis
- porphyromonas
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anti-ccp
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netosis
- periodontitis
- gingivalis
- sclerosis
- fibrinogen
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anti-cyclic
- vimentin
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hla-drb1
- elastase
- autoantigens
- ptpn22
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decondensation
- cl-amidine
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lupus
- erythematosus
- myeloperoxidase
- pharmacology
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self-antigens
-
ra-associated
-
gingipains
- synoviocytes
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rheumatology
- medicine
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arginyl
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erosive
- analysis
- drug development
- fibrin
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non-hla
- filaggrin
Reaction
Synonyms
deiminase, protein (arginine), HL-60 PAD, hPADI2, hPADI4, hPADVI, PAD, PAD 1, PAD 2, PAD 3, PAD 4, PAD II, PAD IV, PAD type 2, PAD-4, PAD-H19, PAD-R11, PAD-R4, PAD1, PAD2, PAD3, PAD4, PAD6, PADI1, Padi2, PADI3, PADI4, peptidyl arginine deiminas 4, peptidyl arginine deiminase, peptidyl arginine deiminase 2, peptidyl-arginine deiminase, peptidylarginine deiminase, peptidylarginine deiminase 1, peptidylarginine deiminase 2, peptidylarginine deiminase 3, peptidylarginine deiminase 4, peptidylarginine deiminase 6, peptidylarginine deiminase isoform VI, peptidylarginine deiminase IV, peptidylarginine deiminase type 4, Peptidylarginine deiminase type alpha, peptidylarginine deiminase type I, peptidylarginine deiminase type II, peptidylarginine deiminase type III, peptidylarginine deiminase type VI, peptidylarginine deiminase-4, PPAD, protein arginine deiminase, protein arginine deiminase 2, protein arginine deiminase 3, protein arginine deiminase 4
ECTree
3.5.3.15 protein-arginine deiminaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.5.3.15 - protein-arginine deiminase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
fibrin L-arginine + H2O
fibrin L-citrulline + NH3
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citrullinated fibrin is a potential antigen of rheumatoid arthritis
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-
?
fibrinogen-L-arginine + H2O
fibrinogen-L-citrulline + NH3
PAD4, involvement in rheumatoid arthritis
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ir
filaggrin-L-arginine + H2O
filaggrin-L-citrulline + NH3
PAD4, involvement in rheumatoid arthritis
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ir
glial fibrillary acidic protein L-arginine + H2O
glial fibrillary acidic protein L-citrulline + NH3
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-
-
?
glial fibrillary acidic protein-L-arginine + H2O
glial fibrillary acidic protein-L-citrulline + NH3
PAD2, involvement in Alzheimer's diease
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ir
glycogen phosphorylase b + H2O
?
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specific deimination by peptidylarginine deiminase has a pronounced effect on the binding of some allosteric effectors with the enzyme and hampers the association of phosphorylase b dimers into tetramers in the presence of AMP
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?
histone H2A-L-arginine + H2O
histone H2A-L-citrulline + NH3
PAD4, involvement in rheumatoid arthritis
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ir
histone H3-L-Arg + H2O
histone H3-L-citrulline
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PADI4 is a histone H3-specific arginine deiminase. Deimination is a mechanism for antagonizing the transcriptional induction mediated by arginine methylation
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?
histone H4-L-arginine + H2O
histone H4-L-citrulline + NH3
PAD4, involvement in rheumatoid arthritis
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ir
histone L-arginine + H2O
histone L-citrulline + NH3
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PAD4 mediates gene expression by regulating Arg methylation and citrullination in histones
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-
?
trichohyalin-L-arginine + H2O
trichohyalin-L-citrulline + NH3
PAD3, involvement in skin disease
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ir
vimentin-L-arginine + H2O
vimentin-L-citrulline + NH3
PAD2, involvement in Alzheimer's disease
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ir
histone H3-L-arginine + H2O
histone H3-L-citrulline + NH3
PAD4, involvement in rheumatoid arthritis
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ir
keratin-L-arginine + H2O
keratin-L-citrulline + NH3
PAD2, involvement in psoriasis
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ir
myelin basic protein-L-arginine + H2O
myelin basic protein-L-citrulline + NH3
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PAD2 and PAD4 are involved in the pathogenesis of demyelination diseases such as multiple sclerosis, overview
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?
myelin basic protein-L-arginine + H2O
myelin basic protein-L-citrulline + NH3
PAD2, involvement in multiple sclerosis
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ir
myelin basic protein-L-arginine + H2O
myelin basic protein-L-citrulline + NH3
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-
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?
myelin basic protein-L-arginine + H2O
myelin basic protein-L-citrulline + NH3
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-
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?
protein L-Arg + H2O
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C-1, the most unmodified of the components of myelin basic protein, is an excellent substrate for the enzyme, thereby confirming that the origin of the citrulline in myelin basic protein arises by the action of this enzyme
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?
protein L-Arg + H2O
?
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expression of the enzyme in luminal and glandular epithelia of the uterus is controlled by amount of the steroid hormones estrogen and progesterone
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?
protein L-Arg + H2O
?
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the ureido group on the citrulline formed by the peptidylarginine deiminase modification functions to unfold proteins due to decrease in net charge, loss of potential ionic bonds, and interference with H bonds
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?
protein L-Arg + H2O
?
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peptidylarginine deiminase, acting in concert with arginine-specific proteinases from Porphyromonas gingivalis, promotes the growth of the pathogen in the periodontal pocket, initially by enhancing its survivability and then by assisting the organism in its circumvention of host humoral defenses
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?
protein L-Arg + H2O
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all-trans retinoic acid increases peptidylarginine deiminase activity in a newborn rat keratinocyte cell line
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?
protein L-Arg + H2O
?
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citrullyl residues in the membranous protein of horny cells of the epidermis of newborn rat are formed by the action of epidermal peptidylarginine deiminase
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?
protein L-Arg + H2O
protein L-citrulline + NH3
peptidyl deiminase type II is the primary enzyme responsible for the conversion of protein bound arginine to citrulline in the central nervous system
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?
protein L-Arg + H2O
protein L-citrulline + NH3
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PAD catalyzes the deimination of the guanidino group from peptidylarginine residues of various peptides to produce peptidylcitrulline and ammonia
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?
protein L-arginine + H2O
protein L-citrulline + NH3
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-
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?
protein L-arginine + H2O
protein L-citrulline + NH3
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-
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?
protein-L-arginine + H2O
protein-L-citrulline + NH3
citrullination of proteins may exert a specific role in the course of PNS development and repair
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-
?
protein-L-arginine + H2O
protein-L-citrulline + NH3
PAD1
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ir
protein-L-arginine + H2O
protein-L-citrulline + NH3
PAD4 is a transcriptional coregulator that catalyzes the calcium-dependent conversion of specific arginine residues in proteins to citrulline and plays a role in the onset and progression of the chronic autoimmune disorder rheumatoid arthritis
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?
protein-L-arginine + H2O
protein-L-citrulline + NH3
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posttranslational convertion, PADI4 plays an essential role in immune cell differentiation and apoptosis, ionomycin-inducible PADI4-decreased cell viability and PADI4-enhanced apoptosis, overview
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?
protein-L-arginine + H2O
protein-L-citrulline + NH3
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-
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ir
protein-L-arginine + H2O
protein-L-citrulline + NH3
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citrullination of proteins may exert a specific role in the course of PNS development and repair
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?
additional information
?
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abnormal accumulation of citrullinated proteins and abnormal activation of PAD2 in hippocampi of patients with Alzheimer's disease, strongly suggests that peptidylarginine deiminase has an important role in the onset and progression of abnormal accumulation of citrullinated proteins and abnormal activation of PAD2 in hippocampi of Alzheimer's disease
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?
additional information
?
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peptidylarginine deiminase type 4 plays an essential role in pathogenesis of rheumatoid arthritis.Peptidylarginine deiminase type 4 may contribute to the disrupted apoptosis of tumors by caspase-mediated claevage of cytokeratin
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?
additional information
?
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the enzyme catalyzes post-translational modification of protein through the conversion of arginine to citrulline in the presence of calcium ions. Peptidylarginine deiminase-mediated deimination of epithelial cell keratin resulting in cytoskeletal remodeling suggests a possible role for hPADVI in cytoskeletal reorganization in the egg and in early embryo development
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?
additional information
?
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the enzyme is involved in autoimmune rheumatoid arthritis
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?
additional information
?
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the enzyme is involved in autoimmune rheumatoid arthritis
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?
additional information
?
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the enzyme is involved in autoimmune rheumatoid arthritis
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?
additional information
?
-
the enzyme is involved in autoimmune rheumatoid arthritis
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?
additional information
?
-
the enzyme is involved in autoimmune rheumatoid arthritis
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?
additional information
?
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the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma
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?
additional information
?
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the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma
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?
additional information
?
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the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma
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?
additional information
?
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the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma
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?
additional information
?
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the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma
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?
additional information
?
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a methylated lysine residue flanking the targeted arginine influences PAD-4-mediated deimination
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?
additional information
?
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the binding affinity of autodeiminated PAD4 for p53 and H3 are similar to non-deiminated PAD4. In contrast, the affinity of autodeiminated PAD4 for HDAC1, PRMT1, and Cit H3 is reduced by 3.7, 4.5, and 10fold, respectively. Results suggest that the autodeimination of PAD4 in vivo could affect its functional activity by regulating its ability to interact with binding partners
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?
additional information
?
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proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis. Pressure-induced translational control of PAD2 expression is consistent with a possible role for PAD2 and citrullination in primary open-angle glaucoma
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?
additional information
?
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proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis. Pressure-induced translational control of PAD2 expression is consistent with a possible role for PAD2 and citrullination in primary open-angle glaucoma
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?
additional information
?
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the cortical granule enzyme plays a role in preimplantation embryonic development
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?
additional information
?
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the cortical granule enzyme plays a role in preimplantation embryonic development
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?
additional information
?
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PAD 6 is essential for oocyte cytoskeletal sheet formation and female fertility, it plays an important role in germ-cell-specific structures in zygote/embryo development, citrullination is a regulator of fertility, overview
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?
additional information
?
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IKKgamma and PAD2 can coimmunoprecipitate in the presence of the Ca2+ ionophore
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?
additional information
?
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PAD2 is involved in some processes of neurodegeneration and myelination in the central nervous system
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?
