3.5.3.15: protein-arginine deiminase

This is an abbreviated version!
For detailed information about protein-arginine deiminase, go to the full flat file.

Word Map on EC 3.5.3.15

3.5.3.15

citrullination

rheumatoid

arthritis

histone

autoimmune

deimination

autoantibody

anti-citrullinated

chromatin

acpas

epitope

synovial

padis

porphyromonas

anti-ccp

netosis

periodontitis

gingivalis

sclerosis

fibrinogen

anti-cyclic

vimentin

hla-drb1

elastase

autoantigens

ptpn22

decondensation

cl-amidine

lupus

erythematosus

myeloperoxidase

pharmacology

self-antigens

ra-associated

gingipains

synoviocytes

rheumatology

medicine

arginyl

erosive

analysis

drug development

fibrin

non-hla

filaggrin

Reaction

Synonyms

deiminase, protein (arginine), HL-60 PAD, hPADI2, hPADI4, hPADVI, PAD, PAD 1, PAD 2, PAD 3, PAD 4, PAD II, PAD IV, PAD type 2, PAD-4, PAD-H19, PAD-R11, PAD-R4, PAD1, PAD2, PAD3, PAD4, PAD6, PADI1, Padi2, PADI3, PADI4, peptidyl arginine deiminas 4, peptidyl arginine deiminase, peptidyl arginine deiminase 2, peptidyl-arginine deiminase, peptidylarginine deiminase, peptidylarginine deiminase 1, peptidylarginine deiminase 2, peptidylarginine deiminase 3, peptidylarginine deiminase 4, peptidylarginine deiminase 6, peptidylarginine deiminase isoform VI, peptidylarginine deiminase IV, peptidylarginine deiminase type 4, Peptidylarginine deiminase type alpha, peptidylarginine deiminase type I, peptidylarginine deiminase type II, peptidylarginine deiminase type III, peptidylarginine deiminase type VI, peptidylarginine deiminase-4, PPAD, protein arginine deiminase, protein arginine deiminase 2, protein arginine deiminase 3, protein arginine deiminase 4

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.3 In linear amidines

3.5.3.15 protein-arginine deiminase

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Results	in table
12	Activating Compound
2099	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
12	Crystallization (Commentary)
1778	Disease/ Diagnostics
9	Expression
20	General Information
2	General Stability
35	IC50 Value
123	Inhibitors
178	kcat/KM [mM/s]
7	Ki Value [mM]
237	KM Value [mM]
40	Localization
53	Metals/Ions
24	Molecular Weight [Da]
72	Natural Substrates/ Products (Substrates)
199	Organism
1	Pathway
62	PDB ID
26	pH Optimum
7	pH Range
2	pI Value
5	Posttranslational Modification
136	Protein Variants
23	Purification (Commentary)
1	Reaction
1	Reaction Type
152	Reference
257	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
510	Substrates and Products (Substrate)
20	Subunits
224	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
203	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.5.3.15 - protein-arginine deiminase

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100000

Mus musculus

peptidyl arginine deiminase II and III, gel filtration

209424

125000

Bos taurus

gel filtration

209413

46600

Porphyromonas gingivalis

1 * 46600, SDS-PAGE

209427

47000

Porphyromonas gingivalis

gel filtration

48000

gel filtration

54000

peptidyl arginine deiminase I, gel filtration

209424

60880

Porphyromonas gingivalis

calculated mass of truncated PAD with its poly-His and Xpress epitope tags

711019

60890

Porphyromonas gingivalis

MALDI-TOF mass spectrometry

711019

64000

Giardia intestinalis

estimated from amino acid sequence

699105

73700

Gallus gallus

E1C0W6, F1NP39, S6BNL5

x * 73700, isoform PAD1, SDS-PAGE

733680

74200

Gallus gallus

E1C0W6, F1NP39, S6BNL5

x * 74200, isoform PAD2, SDS-PAGE

733680

74500

Gallus gallus

E1C0W6, F1NP39, S6BNL5

x * 74500, isoform PAD3, SDS-PAGE

733680

75000

3 entries

75036

Rattus norvegicus

x * 75036, calculation from nucleotide sequence

209425

76000

3 entries

76260

Mus musculus

x * 76260, calculation from nucleotide sequence

209419

81000

Mus musculus

x * 81000, peptidyl arginine deiminase II, SDS-PAGE

83000

x * 83000, SDS-PAGE

85000