3.5.3.12: agmatine deiminase
This is an abbreviated version!
For detailed information about agmatine deiminase, go to the full flat file.
Word Map on EC 3.5.3.12
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3.5.3.12
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ornithine
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biogenic
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agdis
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n-carbamoylputrescine
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tyramine
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cremoris
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medicine
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one-component
-
hilgardii
-
cheeses
-
drug development
-
nutrition
-
analysis
-
food industry
- 3.5.3.12
- ornithine
-
biogenic
-
agdis
- n-carbamoylputrescine
- tyramine
- cremoris
- medicine
-
one-component
- hilgardii
-
cheeses
- drug development
- nutrition
- analysis
- food industry
Reaction
Synonyms
AgD, AgDI, agmatine amidinohydrolase, agmatine deiminase, agmatine deiminaseHpAgD, agmatine iminohydrolase, agu2A, AguA, aguA protein, AguA1, aguA2, AIH, More, PgAgD, putrescine synthase, SmAgD
ECTree
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Reaction
Reaction on EC 3.5.3.12 - agmatine deiminase
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agmatine + H2O = N-carbamoylputrescine + NH3
the enzyme does not show activity of EC 2.1.3.3, ornithine carbamoyltransferase, EC 2.1.3.6, putrescine carbamoyltransferase, and EC 2.7.2.2, carbamate kinase, while putrescine synthase is a multifunctional enzyme, overview
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agmatine + H2O = N-carbamoylputrescine + NH3
the plant enzyme also catalyzes the reactions of EC 2.1.3.3, ornithine carbamoyltransferase, EC 2.1.3.6, putrescine carbamoyltransferase, and EC 2.7.2.2, carbamate kinase, thus functioning as a putrescine synthase, converting agmatine and ornithine into putrescine and citrulline, respectively, Cys180 and Cys366 are involved in catalysis but are not essential, residues are located in the substrate binding pocket
agmatine + H2O = N-carbamoylputrescine + NH3
like other GME hydrolases the enzyme possesses a high pKa active site Cys, suggesting that the enzyme employs a reverse protonation mechanism
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agmatine + H2O = N-carbamoylputrescine + NH3
like other GME hydrolases the enzyme possesses a high pKa active site Cys, suggesting that the enzyme employs a reverse protonation mechanism
-
agmatine + H2O = N-carbamoylputrescine + NH3
like other GME hydrolases the enzyme possesses a high pKa active site Cys, suggesting that the enzyme employs a reverse protonation mechanism
-