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3.5.2.9: 5-oxoprolinase (ATP-hydrolysing)

This is an abbreviated version!
For detailed information about 5-oxoprolinase (ATP-hydrolysing), go to the full flat file.

Word Map on EC 3.5.2.9

Reaction

ATP
+
5-oxo-L-proline
 + 2 H2O =
ADP
 +
phosphate
 +
L-glutamate

Synonyms

5-OPase, 5-oxo-L-prolinase, 5-oxoprolinase, 5OPase, ATP-dependent 5-oxoprolinase, FgOXP1, FgOXP2, FGSG_04902, FGSG_10203, L-pyroglutamate hydrolase, OPase, oplA, OPLAH, oxoprolinase, OXP1, PA4511, prokaryotic 5-oxoprolinase, PxpA, pxpA3, pxpB, pxpC, pyroglutamase, pyroglutamase (ATP-hydrolysing), pyroglutamate hydrolase, pyroglutamic hydrolase, SSO1667

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.9 5-oxoprolinase (ATP-hydrolysing)

Substrates Products

Substrates Products on EC 3.5.2.9 - 5-oxoprolinase (ATP-hydrolysing)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-imidazolidone-4-carboxylate + ATP + H2O
2-imidazolidone + ADP + phosphate
show the reaction diagram
2-imidazoline-4-carboxylate + ATP + H2O
2-imidazoline-4-carboxylate + ADP + phosphate
show the reaction diagram
-
does not undergo ring cleavage, but stimulates formation of inorganic phosphate from ATP
-
-
?
2-imidazolinone-4-carboxylate + H2O
?
show the reaction diagram
-
-
-
-
?
2-oxo-5,5-dimethylthiazolidine-4-carboxylate + H2O
?
show the reaction diagram
-
-
-
-
?
2-piperidone-6-carboxylate + ATP + H2O
2-aminoadipate + phosphate + ADP
show the reaction diagram
2-thiazolinone-4-carboxylate + H2O
?
show the reaction diagram
-
-
-
-
?
3-methyl-5-oxoproline + H2O
2-amino-3-methylpentanedioic acid
show the reaction diagram
-
-
-
-
?
3-oxy-5-oxoproline + H2O
3-oxyglutamate + phosphate
show the reaction diagram
4-methyl-5-oxoproline + H2O
2-amino-4-methylpentanedioic acid
show the reaction diagram
-
-
-
-
?
4-oxy-5-oxoproline + H2O
4-oxyglutamate + phosphate
show the reaction diagram
5'-p-fluorosulfonylbenzoyladenosine + H2O
?
show the reaction diagram
-
-
-
-
?
5'-p-fluorosulfonylbenzoylinosine + H2O
?
show the reaction diagram
-
-
-
-
?
5-oxo-L-proline + ATP + 2 H2O
L-glutamate + phosphate + ADP
show the reaction diagram
-
assay at pH 7.2, 5 mM substrate, 4°C, 20 min
-
-
?
5-oxo-L-proline + ATP + H2O
L-glutamate + ADP + phosphate
show the reaction diagram
assay at 30°C, pH 9.5, reaction stopped by 20 microl acetic acid and heating for 5 min at 100°C
-
-
?
5-oxo-L-proline + H2O + ATP
L-glutamate + ADP + phosphate
show the reaction diagram
alpha-hydroxyglutarate lactone + H2O
?
show the reaction diagram
-
-
-
-
?
ATP + 5-oxo-L-proline + 2 H2O
ADP + phosphate + L-glutamate
show the reaction diagram
ATP + H2O
?
show the reaction diagram
CTP + H2O
?
show the reaction diagram
dATP + H2O
?
show the reaction diagram
DL-2-oxo-3,3-dimethylthiazolidine-4-carboxylate + H2O
?
show the reaction diagram
-
-
-
-
?
DL-cis-2-oxo-5-methyloxazolidine-4-carboxylate + H2O
DL-threonine + ADP + phosphate
show the reaction diagram
-
-
-
-
?
GTP + H2O
?
show the reaction diagram
ITP + H2O
?
show the reaction diagram
L-2-iminothiazolidine-4-carboxylate + H2O
L-cystine
show the reaction diagram
-
-
-
-
?
L-2-oxooxazolidine-4-carboxylate + H2O + ATP
L-serine + ADP + phosphate
show the reaction diagram
-
-
-
-
?
L-2-oxothiazolidine-4-carboxylate + H2O + ATP
L-cysteine + ADP + phosphate
show the reaction diagram
L-2-oxothiazolidine-4-carboxylic acid + H2O
L-cysteine + ADP + phosphate
show the reaction diagram
L-dihydroorotate + H2O
?
show the reaction diagram
-
do not undergo ring cleavage, but stimulates formation of inorganic phosphate from ATP
-
-
?
L-trans-2-oxo-5-methyloxazolidine-4-carboxylate + H2O
L-threonine + ADP + phosphate
show the reaction diagram
-
-
-
-
?
MgATP2- + H2O
?
show the reaction diagram
UTP + H2O
?
show the reaction diagram
XTP + H2O
?
show the reaction diagram
-
less than 5% of the activity observed with ATP
-
-
?
additional information
?
-