3.5.2.3: dihydroorotase
This is an abbreviated version!
For detailed information about dihydroorotase, go to the full flat file.
Word Map on EC 3.5.2.3
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3.5.2.3
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pyrimidine
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transcarbamoylase
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carbamoyl-phosphate
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phosphoribosyltransferase
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atcase
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orotidine
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carbamoyltransferase
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glutamine-dependent
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l-dihydroorotate
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2.1.3.2
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cpsase
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pyre
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dihydropyrimidinase
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hydantoinase
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dihydro-ouabain
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n-phosphonacetyl-l-aspartate
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n-carbamyl-l-aspartate
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allantoinase
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imidase
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synthesis
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succinate-grown
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amidohydrolases
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6.3.5.5
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drug development
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medicine
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5-fluoroorotate
- 3.5.2.3
- pyrimidine
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transcarbamoylase
- carbamoyl-phosphate
- phosphoribosyltransferase
- atcase
- orotidine
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carbamoyltransferase
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glutamine-dependent
- l-dihydroorotate
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2.1.3.2
- cpsase
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pyre
- dihydropyrimidinase
- hydantoinase
- dihydro-ouabain
- n-phosphonacetyl-l-aspartate
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n-carbamyl-l-aspartate
- allantoinase
- imidase
- synthesis
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succinate-grown
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amidohydrolases
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6.3.5.5
- drug development
- medicine
- 5-fluoroorotate
Reaction
Synonyms
amidohydrolase family protein, BcDHOase, CAD, carbamoylaspartic dehydrase, Class I DHOase, DHO, DHOase, dihydroorotase, dihydroorotase domain, dihydroorotate dehydrolase, hDHOase, huDHOase, human DHOase domain, LdDHOase, More, pyrC, type I DHOase, type II DHO, VcDHO, YpDHO
ECTree
3.5.2.3 dihydroorotaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 3.5.2.3 - dihydroorotase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(S)-1,2,3,6-tetrahydro-6-oxopyridine-2-carboxylic acid
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competitive inhibitor versus dihydroorotate and thio-dihydroorotate
1-(8-methoxy-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)ethan-1-one
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4(R)-hydroxy-6-oxo-piperidine-2(S)-carboxylic acid
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competitive inhibitor versus dihydroorotate and thio-dihydroorotate
4(S)-hydroxy-6-oxo-piperidine-2(S)-carboxylic acid
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competitive inhibitor versus dihydroorotate and thio-dihydroorotate
4,6-dioxo-piperidine-2-(S)-carboxylic acid
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most active competitive inhibitor versus dihydroorotate and thio-dihydroorotate
6'-methoxy-2',3',4',9'-tetrahydrospiro[oxane-4,1'-pyrido[3,4-b]indole]
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desferrioxamine
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hypoxia causes a decrease in carbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase expression incubated under desferrioxamine-induced HIF-1alpha accumulation detected in A293T, IMR32, colo320DM and HeLa cell lines
DHCEDD
the peptide corresponds to the sequence 179DHCEDD185, and causes 50% inhibition of the wild-type enzyme
DHCEDDKLA
the peptide corresponds to the sequence 179DHCEDDKLA187, and causes 76% inhibition of the wild-type enzyme
diethyl dicarbonate
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strong inhibition at 1 mM, activity is restored more than 95% when the enzyme is preincubated with both 1 mM diethyl dicarbonate and 5 mM L-carbamoyl-L-aspartate
[6-fluoro-1-(methylsulfanyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]cyanamide
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[6-methoxy-1-(methylsulfanyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]cyanamide
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2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylic acid
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at 37°C or 60°C the enzyme binds 2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylic acid more tightly than DHO
2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylic acid
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competitive inhibitor
2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylic acid
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at 37°C or 60°c the enzyme binds 2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylic acid only slightly more strongly than DHO; competitive inhibitor
kaempferol
kaempferol mediates perturbation of the pyrimidine pathway
additional information
pressure induces irreversible dissociation of the obligate ATC trimer, and as a consequence the DHO is also inactivated. Inhibition of DHO by small peptides that mimic the loop residues
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additional information
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pressure induces irreversible dissociation of the obligate ATC trimer, and as a consequence the DHO is also inactivated. Inhibition of DHO by small peptides that mimic the loop residues
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additional information
inhibitor high-throughput screening, competitive inhibition, determination of the equilibrium dissociation constant determined by surface plasmon resonance with 1 mM N-carbamoyl-L-aspartate, overview
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additional information
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inhibitor high-throughput screening, competitive inhibition, determination of the equilibrium dissociation constant determined by surface plasmon resonance with 1 mM N-carbamoyl-L-aspartate, overview
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additional information
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hypoxia causes a decrease in carbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase expression detected in A293T, IMR32, HeLa cell lines and human endometiral stromal cells
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additional information
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binding and inhibition of allantoinase dihydroorotase by flavonols and the substrates of other cyclic amidohydrolases, dissociation constants, docking analysis using three-dimensional structure model, PDB ID 3JZE, overview. Hydantoin and allantoin bind to dihydroorotase, but do not affect its activity, no inhibition by phthalimide
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additional information
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EDTA and 1,10-phenanthroline have no effect on the enzyme activity; L-carbamoyl-L-aspartate and L-dihydroorotate have no inhibitory effect on the enzyme at the pH 7.4
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additional information
malate can bind to the active site
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