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3.5.1.9: arylformamidase

This is an abbreviated version!
For detailed information about arylformamidase, go to the full flat file.

Word Map on EC 3.5.1.9

Reaction

N-formyl-L-kynurenine
+
H2O
=
formate
 +
L-kynurenine

Synonyms

AFMID, Bna7p, FKF, formamidase I, formamidase II, formyl kynurenine formamidase, formylase, formylkynureninase, formylkynurenine formamidase, KFA, KFase, KynB, kynurenine formamidase, kynurine formamidase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.9 arylformamidase

Specific Activity

Specific Activity on EC 3.5.1.9 - arylformamidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00002
-
liver knockout mutant enzyme
0.00087
-
kidney knockout mutant enzyme
0.0038
-
kidney heterozygous mutant enzyme
0.0067
-
kidney wild-type enzyme
0.0083
-
liver heterozygous mutant enzyme
0.0156
-
liver wild-type enzyme
0.26
-
formamidase I
0.33
-
-
0.48
-
formamidase II
0.8
-
-
22.8
-
-
26.8
-
formamidase II
3
pH 7.4, temperature not specified in the publication, purified recombinant His6-tagged enzyme
3.5
-
1 mM N-formyl-L-kynurenine, pH 7.4, 37°C
303
-
-
346
-
-
4.7
-
1 mM N-formyl-L-kynurenine, pH 7.4, 37°C
42
purified recombinant wild-type enzyme
425
-
-
5.9
-
1 mM N-formyl-L-kynurenine, pH 7.4, 37°C
8.33
-
formamidase I
additional information
-
determination of kynurenine pathway metabolites concentrations in plasma of wild-type and mutant mice