3.5.1.79: Phthalyl amidase

This is an abbreviated version!
For detailed information about Phthalyl amidase, go to the full flat file.

Reaction

Synonyms

Amidase, phthalyl, o-Phthalyl amidase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.79 Phthalyl amidase

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Results	in table
34	AA Sequence
6	Application
1	CAS Registry Number
1	Cloned(Commentary)
4	General Stability
9	Inhibitors
5	KM Value [mM]
3	Molecular Weight [Da]
5	Organism
2	pH Optimum
1	pH Range
3	Purification (Commentary)
2	Reaction
1	Reaction Type
5	Reference
2	Specific Activity [micromol/min/mg]
12	Substrates and Products (Substrate)
4	Subunits
2	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.5.1.79 - Phthalyl amidase

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SYSTEMATIC NAME

IUBMB Comments

Phthalyl-amide amidohydrolase

In the entry, "phthalyl" is used to mean "2-carboxybenzoyl". The enzyme from Xanthobacter agilis hydrolyses phthalylated amino acids, peptides, beta-lactams, aromatic and aliphatic amines. The substituent on nitrogen may be an alkyl group, but may also be complex, giving an amino acid or peptide derivative. Substitutions on the phthalyl ring include 6-F, 6-NH2, 3-OH, and a nitrogen in the aromatic ring ortho to the carboxy group attached to the amine. No cofactors are required