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3.5.1.78: Glutathionylspermidine amidase

This is an abbreviated version!
For detailed information about Glutathionylspermidine amidase, go to the full flat file.

Word Map on EC 3.5.1.78

Reaction

glutathionylspermidine
+
H2O
=
glutathione
+
spermidine

Synonyms

Amidase, glutathionylspermidine, Glutathionylspermidine amidohydrolase (spermidine-forming), Glutathionylspermidine amidohydrolase [spermidine-forming], Glutathionylspermidine synthetase/amidase, GSP amidase, Gsp synthetase/amidase, GspA, GspSA, GSS, trypanothione synthetase-amidase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.78 Glutathionylspermidine amidase

Reference

Reference on EC 3.5.1.78 - Glutathionylspermidine amidase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lin, C.H.; Chen, S.; Kwon, D.S.; Coward, J.K.; Walsh, C.T.
Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase
Chem. Biol.
4
859-866
1997
Escherichia coli
Manually annotated by BRENDA team
Chen, S.; Lin, C.H.; Kwon, D.S.; Walsh, C.T.; Coward, J.K.
Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli
J. Med. Chem.
40
3842-3850
1997
Escherichia coli
Manually annotated by BRENDA team
Bollinger, J.M.; Kwon, D.S.; Huisman, G.W.; Kolter, R.; Walsh, C.T.
Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase
J. Biol. Chem.
270
14031-14041
1995
Escherichia coli
Manually annotated by BRENDA team
Lin, C.H.; Kwon, D.S.; Bollinger, J.M.; Walsh, C.T.
Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli
Biochemistry
36
14930-14938
1997
Escherichia coli
Manually annotated by BRENDA team
Oza, S.L.; Ariyanayagam, M.R.; Fairlamb, A.H.
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata
Biochem. J.
364
679-686
2002
Crithidia fasciculata
Manually annotated by BRENDA team
Fyfe, P.K.; Oza, S.L.; Fairlamb, A.H.; Hunter, W.N.
Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities
J. Biol. Chem.
283
17672-17680
2008
Leishmania major
Manually annotated by BRENDA team
Chiang, B.Y.; Chen, T.C.; Pai, C.H.; Chou, C.C.; Chen, H.H.; Ko, T.P.; Hsu, W.H.; Chang, C.Y.; Wu, W.F.; Wang, A.H.; Lin, C.H.
Protein S-thiolation by Glutathionylspermidine (Gsp): the role of Escherichia coli Gsp synthetase/amidase in redox regulation
J. Biol. Chem.
285
25345-25353
2010
Escherichia coli K-12 (P0AES0)
Manually annotated by BRENDA team
Pai, C.H.; Wu, H.J.; Lin, C.H.; Wang, A.H.
Structure and mechanism of Escherichia coli glutathionylspermidine amidase belonging to the family of cysteine; histidine-dependent amidohydrolases/peptidases
Protein Sci.
20
557-566
2011
Escherichia coli (P0AES0), Escherichia coli
Manually annotated by BRENDA team
Chong, C.; Gao, S.; Chiang, B.; Hsu, W.; Lin, T.; Chen, T.; Lin, C.
An acyloxymethyl ketone-based probe to monitor the activity of glutathionylspermidine amidase in Escherichia coli
ChemBioChem
12
2306-2309
2011
Escherichia coli (P0AES0), Escherichia coli
Manually annotated by BRENDA team
Chattopadhyay, M.K.; Chen, W.; Tabor, H.
Escherichia coli glutathionylspermidine synthetase/amidase: phylogeny and effect on regulation of gene expression
FEMS Microbiol. Lett.
338
132-140
2013
Escherichia coli (P0AES0), Escherichia coli
Manually annotated by BRENDA team
Sui, L.; Warren, J.C.; Russell, J.P.; Stourman, N.V.
Comparison of the functions of glutathionylspermidine synthetase/amidase from E. coli and its predicted homologues YgiC and YjfC
Int. J. Biochem. Mol. Biol.
3
302-312
2012
Escherichia coli (P0AES0), Escherichia coli
Manually annotated by BRENDA team