3.5.1.78: Glutathionylspermidine amidase

This is an abbreviated version!
For detailed information about Glutathionylspermidine amidase, go to the full flat file.

Word Map on EC 3.5.1.78

3.5.1.78

trypanosomatids

gsh

leishmania

polyamine

histidine-dependent

fasciculata

gamma-glu-cys-gly

synthetases

tetrahedral

n1,n8-bisglutathionylspermidine

crithidia

kinetoplastida

s-thiolation

anti-parasitic

thiol-redox

druggable

neglected

sulfenic

slow-binding

tripeptide

phosphonate

protozoa

ligases

Reaction

Synonyms

Amidase, glutathionylspermidine, Glutathionylspermidine amidohydrolase (spermidine-forming), Glutathionylspermidine amidohydrolase [spermidine-forming], Glutathionylspermidine synthetase/amidase, GSP amidase, Gsp synthetase/amidase, GspA, GspSA, GSS, trypanothione synthetase-amidase

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.78 Glutathionylspermidine amidase

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Results	in table
348	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
1	Cofactor
2	Crystallization (Commentary)
4	General Information
1	General Stability
3	IC50 Value
8	Inhibitors
7	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
11	Organism
2	Pathway
15	PDB ID
1	pH Optimum
6	Protein Variants
4	Purification (Commentary)
3	Reaction
1	Reaction Type
11	Reference
1	Renatured (Commentary)
1	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
3	Subunits
22	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

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General Information on EC 3.5.1.78 - Glutathionylspermidine amidase

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evolution

2 entries

metabolism

Escherichia coli

P0AES0

microarray studies comparing gss+ and DELTAgss strains of Escherichia coli show that a large number of genes are either upregulated (76 genes more than 3fold) or downregulated (35 genes more than 3fold) by the loss of the gss gene. Most significant categories of up-regulated genes include sulfur utilization, glutamine and succinate metabolism, polyamine and arginine metabolism, and purine and pyrimidine metabolism

727554

additional information

2 entries