3.5.1.78: Glutathionylspermidine amidase
This is an abbreviated version!
For detailed information about Glutathionylspermidine amidase, go to the full flat file.
Word Map on EC 3.5.1.78
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3.5.1.78
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trypanosomatids
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gsh
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leishmania
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polyamine
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histidine-dependent
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fasciculata
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gamma-glu-cys-gly
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synthetases
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tetrahedral
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n1,n8-bisglutathionylspermidine
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crithidia
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kinetoplastida
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s-thiolation
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anti-parasitic
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thiol-redox
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druggable
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neglected
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sulfenic
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slow-binding
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tripeptide
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phosphonate
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protozoa
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ligases
- 3.5.1.78
-
trypanosomatids
- gsh
- leishmania
- polyamine
-
histidine-dependent
- fasciculata
- gamma-glu-cys-gly
- synthetases
-
tetrahedral
-
n1,n8-bisglutathionylspermidine
-
crithidia
- kinetoplastida
-
s-thiolation
-
anti-parasitic
-
thiol-redox
-
druggable
-
neglected
-
sulfenic
-
slow-binding
- tripeptide
- phosphonate
-
protozoa
- ligases
Reaction
Synonyms
Amidase, glutathionylspermidine, Glutathionylspermidine amidohydrolase (spermidine-forming), Glutathionylspermidine amidohydrolase [spermidine-forming], Glutathionylspermidine synthetase/amidase, GSP amidase, Gsp synthetase/amidase, GspA, GspSA, GSS, trypanothione synthetase-amidase
ECTree
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Cloned on EC 3.5.1.78 - Glutathionylspermidine amidase
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gene gsp, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
gene gss, phylogenetic and global transcriptome analyses, microarray studies comparing gss+ and DELTAgss strains of Escherichia coli show that a large number of genes are either upregulated (76 genes more than 3fold) or downregulated (35 genes more than 3fold) by the loss of the gss gene. Most significant categories of up-regulated genes include sulfur utilization, glutamine and succinate metabolism, polyamine and arginine metabolism, and purine and pyrimidine metabolism