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3.5.1.60: N-(long-chain-acyl)ethanolamine deacylase

This is an abbreviated version!
For detailed information about N-(long-chain-acyl)ethanolamine deacylase, go to the full flat file.

Reaction

N-(long-chain-acyl)ethanolamine
+
H2O
=
a long-chain carboxylate
+
ethanolamine

Synonyms

acylethanolamine acid amidase, amidase, acylethanolamine, hNAAA, N-acylethanolamine acid amidase, N-acylethanolamine amidohydrolase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, Nacylethanolamine acid amidase, NAE-hydrolyzing acid amidase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.60 N-(long-chain-acyl)ethanolamine deacylase

Systematic Name

Systematic Name on EC 3.5.1.60 - N-(long-chain-acyl)ethanolamine deacylase

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SYSTEMATIC NAME
IUBMB Comments
N-(long-chain-acyl)ethanolamine amidohydrolase
This lysosomal enzyme acts best on palmitoyl ethanolamide, with lower activity on other N-(long-chain-acyl)ethanolamines. It is only active at acidic pH. Unlike EC 3.5.1.99, fatty acid amide hydrolase, it does not act on primary amides such as oleamide, and has only a marginal activity with anandamide. The enzyme is translated as an inactive proenzyme, followed by autocatalytic cleavage into two subunits that reassociate to form an active heterodimeric complex.