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3.5.1.60: N-(long-chain-acyl)ethanolamine deacylase

This is an abbreviated version!
For detailed information about N-(long-chain-acyl)ethanolamine deacylase, go to the full flat file.

Reaction

N-(long-chain-acyl)ethanolamine
+
H2O
=
a long-chain carboxylate
+
ethanolamine

Synonyms

acylethanolamine acid amidase, amidase, acylethanolamine, hNAAA, N-acylethanolamine acid amidase, N-acylethanolamine amidohydrolase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, Nacylethanolamine acid amidase, NAE-hydrolyzing acid amidase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.60 N-(long-chain-acyl)ethanolamine deacylase

Reference

Reference on EC 3.5.1.60 - N-(long-chain-acyl)ethanolamine deacylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schmid, P.C.; Zuzarte-Augustin, M.L.; Schmid, H.H.O.
Properties of rat liver N-acylethanolamine amidohydrolase
J. Biol. Chem.
260
14145-14149
1985
Rattus norvegicus
Manually annotated by BRENDA team
Hansen, H.; Lauritzen, L.; Moesgaard, B.; Strand, A.M.; Hansen, H.
Formation of N-acyl-phoshatidylethanolamines and N-acylethanolamines: proposed role in neurotoxicity
Biochem. Pharmacol.
55
719-725
1998
Homo sapiens, Mus sp., Rattus norvegicus
Manually annotated by BRENDA team
Yamano, Y.; Tsuboi, K.; Hozaki, Y.; Takahashi, K.; Jin, X.H.; Ueda, N.; Wada, A.
Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase
Bioorg. Med. Chem.
20
3658-3665
2012
Rattus norvegicus (Q5KTC7), Rattus norvegicus Wistar/ST (Q5KTC7)
Manually annotated by BRENDA team
Fiasella, A.; Nuzzi, A.; Summa, M.; Armirotti, A.; Tarozzo, G.; Tarzia, G.; Mor, M.; Bertozzi, F.; Bandiera, T.; Piomelli, D.
3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration
ChemMedChem
9
1602-1614
2014
Homo sapiens (Q02083)
Manually annotated by BRENDA team
West, J.; Zvonok, N.; Whitten, K.; Wood, J.; Makriyannis, A.
Mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid midase
J. Proteome Res.
11
972-981
2012
Homo sapiens (Q02083)
Manually annotated by BRENDA team
Bandiera, T.; Ponzano, S.; Piomelli, D.
Advances in the discovery of N-acylethanolamine acid amidase inhibitors
Pharmacol. Res.
86
11-17
2014
Mus musculus, Homo sapiens (Q02083), Rattus norvegicus (Q5KTC7)
Manually annotated by BRENDA team
Li, Y.; Yang, L.; Chen, L.; Zhu, C.; Huang, R.; Zheng, X.; Qiu, Y.; Fu, J.
Design and synthesis of potent N-acylethanolamine-hydrolyzing acid amidase (NAAA) inhibitor as anti-inflammatory compounds
PLoS ONE
7
e43023
2012
Rattus norvegicus (Q5KTC7)
Manually annotated by BRENDA team
West, J.M.; Zvonok, N.; Whitten, K.M.; Vadivel, S.K.; Bowman, A.L.; Makriyannis, A.
Biochemical and mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid amidase inhibition
PLoS ONE
7
e43877
2012
Homo sapiens (Q02083), Homo sapiens
Manually annotated by BRENDA team
Ribeiro, A.; Pontis, S.; Mengatto, L.; Armirotti, A.; Chiurchiu, V.; Capurro, V.; Fiasella, A.; Nuzzi, A.; Romeo, E.; Moreno-Sanz, G.; Maccarrone, M.; Reggiani, A.; Tarzia, G.; Mor, M.; Bertozzi, F.; Bandiera, T.; Piomelli, D.
A potent systemically active N-acylethanolamine acid amidase inhibitor that suppresses inflammation and human macrophage activation
ACS Chem. Biol.
10
1838-1846
2015
Homo sapiens (Q02083), Rattus norvegicus (Q5KTC7), Mus musculus (Q9D7V9), Mus musculus C57BL/6J (Q9D7V9)
Manually annotated by BRENDA team
Romeo, E.; Ponzano, S.; Armirotti, A.; Summa, M.; Bertozzi, F.; Garau, G.; Bandiera, T.; Piomelli, D.
Activity-based probe for N-acylethanolamine acid amidase
ACS Chem. Biol.
10
2057-2064
2015
Homo sapiens (Q02083), Rattus norvegicus (Q5KTC7), Rattus norvegicus Sprague-Dawley (Q5KTC7)
Manually annotated by BRENDA team
Sakura, Y.; Tsuboi, K.; Uyama, T.; Zhang, X.; Taoka, R.; Sugimoto, M.; Kakehi, Y.; Ueda, N.
A quantitative study on splice variants of N-acylethanolamine acid amidase in human prostate cancer cells and other cells
Biochim. Biophys. Acta
1861
1951-1958
2016
Homo sapiens (Q02083)
Manually annotated by BRENDA team
Vago, R.; Bettiga, A.; Salonia, A.; Ciuffreda, P.; Ottria, R.
Development of new inhibitors for N-acylethanolamine-hydrolyzing acid amidase as promising tool against bladder cancer
Bioorg. Med. Chem.
25
1242-1249
2017
Homo sapiens (Q02083)
Manually annotated by BRENDA team
Petracca, R.; Romeo, E.; Baggelaar, M.P.; Artola, M.; Pontis, S.; Ponzano, S.; Overkleeft, H.S.; van der Stelt, M.; Piomelli, D.
Novel activity-based probes for N-acylethanolamine acid amidase
Chem. Commun. (Camb.)
53
11810-11813
2017
Homo sapiens (Q02083)
Manually annotated by BRENDA team
Li, Y.; Chen, Q.; Yang, L.; Li, Y.; Zhang, Y.; Qiu, Y.; Ren, J.; Lu, C.
Identification of highly potent N-acylethanolamine acid amidase (NAAA) inhibitors optimization of the terminal phenyl moiety of oxazolidone derivatives
Eur. J. Med. Chem.
139
214-221
2017
Rattus norvegicus (Q5KTC7)
Manually annotated by BRENDA team
Sasso, O.; Summa, M.; Armirotti, A.; Pontis, S.; De Mei, C.; Piomelli, D.
The N-Acylethanolamine acid amidase inhibitor ARN077 suppresses inflammation and pruritus in a mouse model of allergic dermatitis
J. Invest. Dermatol.
138
562-569
2018
Mus musculus, Mus musculus CD-1
Manually annotated by BRENDA team
Zhou, P.; Xiang, L.; Zhao, D.; Ren, J.; Qiu, Y.; Li, Y.
Synthesis, biological evaluation, and structure activity relationship (SAR) study of pyrrolidine amide derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors
MedChemComm
10
252-262
2019
Rattus norvegicus (Q6P7S1)
Manually annotated by BRENDA team
Sagheddu, C.; Scherma, M.; Congiu, M.; Fadda, P.; Carta, G.; Banni, S.; Wood, J.T.; Makriyannis, A.; Malamas, M.S.; Pistis, M.
Inhibition of N-acylethanolamine acid amidase reduces nicotine-induced dopamine activation and reward
Neuropharmacology
144
327-336
2019
Homo sapiens (Q02083), Rattus norvegicus (Q6P7S1), Rattus norvegicus Sprague-Dawley (Q6P7S1)
Manually annotated by BRENDA team
Zhou, P.; Xiang, L.; Yang, Y.; Wu, Y.; Hu, T.; Liu, X.; Lin, F.; Xiu, Y.; Wu, K.; Lu, C.; Ren, J.; Qiu, Y.; Li, Y.
N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritis
Pharmacol. Res.
145
104264
2019
Homo sapiens (Q02083), Rattus norvegicus (Q5KTC7)
Manually annotated by BRENDA team
Gorelik, A.; Gebai, A.; Illes, K.; Piomelli, D.; Nagar, B.
Molecular mechanism of activation of the immunoregulatory amidase NAAA
Proc. Natl. Acad. Sci. USA
115
E10032-E10040
2018
Oryctolagus cuniculus (G1T7U7), Cavia porcellus (H0VCJ6), Homo sapiens (Q02083), Mus musculus (Q9D7V9)
Manually annotated by BRENDA team