3.5.1.60: N-(long-chain-acyl)ethanolamine deacylase
This is an abbreviated version!
For detailed information about N-(long-chain-acyl)ethanolamine deacylase, go to the full flat file.
Reaction
Synonyms
acylethanolamine acid amidase, amidase, acylethanolamine, hNAAA, N-acylethanolamine acid amidase, N-acylethanolamine amidohydrolase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, Nacylethanolamine acid amidase, NAE-hydrolyzing acid amidase
ECTree
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IC50 Value
IC50 Value on EC 3.5.1.60 - N-(long-chain-acyl)ethanolamine deacylase
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1.5
(2E)-3-([1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-one
Rattus norvegicus
pH 4.5, 37°C
4.1
(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)penta-2,4-dien-1-one
Rattus norvegicus
pH 4.5, 37°C
0.02
(2R)-2-hydroxy-N-pentadecyl-2-phenylacetamide
Homo sapiens
pH and temperature not specified in the publication
0.00296
(S)-2-oxo-3-oxetanyl-carbamic acid benzyl ester
Rattus norvegicus
pH and temperature not specified in the publication
0.1
1-(pyrrolidin-1-yl)-3-(thiophen-2-yl)propan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.1
1-(pyrrolidin-1-yl)-3-(thiophen-3-yl)propan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.0141
1-(pyrrolidin-1-yl)-7-(thiophen-2-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0132
1-(pyrrolidin-1-yl)-7-(thiophen-3-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.025
1-hexadecanoylpyrrolidine
Rattus norvegicus
pH and temperature not specified in the publication
0.011
2-hydroxy-N-pentadecylbenzamide
Homo sapiens
pH and temperature not specified in the publication
0.00002
3,5-dichloro-4-nitropyridine
Homo sapiens
pH and temperature not specified in the publication
0.1
3-(2'-chloro[1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.0028
3-(2'-fluoro[1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.1
3-(2'-methyl[1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.0254
3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0018
3-(3'-fluoro[1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0165
3-(3'-methyl[1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0486
3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0034
3-(4'-fluoro[1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0332
3-(4'-methyl[1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.00068
3-(4-phenoxybenzoyl)-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
2.8
3-(4-phenoxycyclohexyl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.1
3-(4-phenoxyphenyl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.48
3-(4-phenylcyclohexyl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.00027
3-(6-phenylhexanoyl)-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.0007
3-(cyclohexyloxy)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0057
3-(pyridin-2-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.1
3-(pyridin-3-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.1
3-[4-(2H-1,3-benzodioxol-5-yl)phenyl]-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.00774
3-[4-(3-chlorophenoxy)benzoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00521
3-[4-(3-methylphenoxy)benzoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.0064
3-[4-(4-methylphenoxy)benzoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.000092
3-[4-(cyclohexyloxy)benzoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00012
3-[4-(cyclopentyloxy)benzoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00064
3-[4-(pentyloxy)benzoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00021
3-[4-[(4-hydroxycyclohexyl)oxy]benzoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00033
3-[4-[(oxan-4-yl)oxy]benzoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00043
3-[6-(3-bromophenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.000026
3-[6-(3-chloro-4-fluorophenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.000009
3-[6-(3-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00016
3-[6-(3-fluoro-4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00864
3-[6-(3-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00312
3-[6-(3-iodophenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.0163
3-[6-(3-methoxyphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00035
3-[6-(3-methylphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.0157
3-[6-(4-aminophenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00851
3-[6-(4-bromophenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.0046
3-[6-(4-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.000061
3-[6-(4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.44
3-[6-(4-methylphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.0128
3-[6-[3-(methylsulfanyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.000058
3-[6-[3-(trifluoromethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00019
3-[6-[4-(hydroxymethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00104
3-[6-[4-(trifluoromethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.1
3-[7-oxo-7-(pyrrolidin-1-yl)heptyl]benzoic acid
Rattus norvegicus
above, pH 4.5, 37°C
0.1
4-[7-oxo-7-(pyrrolidin-1-yl)heptyl]benzoic acid
Rattus norvegicus
above, pH 4.5, 37°C
5.5
5-(2H-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)pentan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.00035
5-(4-(4-(5,5-difluoro-1,3,7,9-tetramethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-10-yl)butyl)-1H-1,2,3-triazol-1-yl)pentyl ((2S,3S)-2-methyl-1-(4-(methylsulfonyl)phenoxy)-4-oxoazetidin-3-yl)carbamate
Homo sapiens
pH 7.4, 37°C
0.00006
5-(norbornan-2-ylmethoxy)pentyl N-[(2S,3S)-2-methyl-1-(4-methylsulfonylphenoxy)-4-oxo-azetidin-3-yl]carbamate
Homo sapiens
pH 7.4, 37°C
0.05
5-phenylpentyl N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate
Homo sapiens
pH 4.5, 37°C
0.1
7-(2-chlorophenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.0137
7-(2-fluorophenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0684
7-(2-methylphenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0037
7-(3-chlorophenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0073
7-(3-fluorophenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.1
7-(3-hydroxyphenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.1
7-(3-methoxyphenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.0083
7-(3-methylphenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.1
7-(3-propylphenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.0345
7-(4-chlorophenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.008
7-(4-fluorophenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0056
7-(4-hydroxyphenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0354
7-(4-methoxyphenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.0096
7-(4-methylphenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
pH 4.5, 37°C
0.1
7-(4-propylphenyl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.1
7-(pyridin-2-yl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.1
7-(pyridin-3-yl)-1-(pyrrolidin-1-yl)heptan-1-one
Rattus norvegicus
above, pH 4.5, 37°C
0.01
benzyl [(2R,3S)-2-methyl-4-oxooxetan-3-yl]carbamate
Rattus norvegicus
above, pH and temperature not specified in the publication
0.001
benzyl [(2S,3R)-2-methyl-4-oxooxetan-3-yl]carbamate
Rattus norvegicus
pH and temperature not specified in the publication
0.01
cyclopentyl hexadecanoate
Homo sapiens
pH and temperature not specified in the publication
0.1
methyl 3-[7-oxo-7-(pyrrolidin-1-yl)heptyl]benzoate
Rattus norvegicus
above, pH 4.5, 37°C
0.1
methyl 4-[7-oxo-7-(pyrrolidin-1-yl)heptyl]benzoate
Rattus norvegicus
above, pH 4.5, 37°C
0.034
N-pentadecylbutanamide
Homo sapiens
pH and temperature not specified in the publication
0.0045
N-pentadecylcyclohexancarboxamide
Rattus norvegicus
pH and temperature not specified in the publication
0.1
N-pentadecylnaphthalene-2-carboxamide
Homo sapiens
above, pH and temperature not specified in the publication
0.1
N-[(2R,3S)-2-methyl-4-oxooxetan-3-yl]-3-phenylpropanamide
Rattus norvegicus
above, pH and temperature not specified in the publication
0.0032
N-[(2S,3R)-2-methyl-4-oxooxetan-3-yl]-3-phenylpropanamide
Rattus norvegicus
pH and temperature not specified in the publication
0.006
N-[(3R)-2-oxo-3-oxetanyl]-3-phenylpropanamide
Rattus norvegicus
pH and temperature not specified in the publication
0.00042
N-[(3S)-2-oxo-3-oxetanyl]-3-phenylpropanamide
Rattus norvegicus
pH and temperature not specified in the publication
0.00046
N-[(3S)-2-oxooxetan-3-yl]heptanamide
Rattus norvegicus
pH and temperature not specified in the publication
0.00016
N-[(3S)-2-oxooxetan-3-yl]naphthalene-2-carboxamide
Rattus norvegicus
pH and temperature not specified in the publication
0.000115
N-[(3S)-2-oxooxetan-3-yl][1,1'-biphenyl]-4-carboxamide
Rattus norvegicus
pH and temperature not specified in the publication
0.000013
undec-10-ynyl N-[(3S)-2-oxoazetidin-3-yl]carbamate
Rattus norvegicus
pH and temperature not specified in the publication
0.000006
undec-10-ynyl-N-[(3S)-2-oxoazetidin-3-yl]carbamate
Homo sapiens
pH and temperature not specified in the publication
0.00023
[2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone
Homo sapiens
pH 4.5, 37°C, recombinant enzyme
0.078
(2S)-2-hydroxy-N-pentadecyl-2-phenylacetamide
Homo sapiens
pH and temperature not specified in the publication
0.000007
Homo sapiens
pH and temperature not specified in the publication
0.000007
([1,1'-biphenyl]-4-yl)methyl [(2S,3R)-2-methyl-4-oxooxetan-3-yl]carbamate
Rattus norvegicus
pH and temperature not specified in the publication
0.00035
Homo sapiens
recombinant enzyme with substrate N-(4-methyl coumarin)palmitamide, pH not specified in the publication, 37°C
0.00035 - 0.0006
1-isothiocyanatopentadecane
Homo sapiens
pH and temperature not specified in the publication
0.0006
1-isothiocyanatopentadecane
Homo sapiens
recombinant enzyme with substrate N-palmitoylethanolamine, pH not specified in the publication, 37°C
0.038
2,5-dihydroxy-N-pentadecylbenzamide
Homo sapiens
pH and temperature not specified in the publication
0.0021
Rattus norvegicus
pH 4.5, 37°C
0.00212
3-([1,1'-biphenyl]-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Rattus norvegicus
pH and temperature not specified in the publication
0.00048
Rattus norvegicus
above, pH and temperature not specified in the publication
0.00134
3-[4-[(pentan-3-yl)oxy]benzoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above, pH and temperature not specified in the publication
0.000027
Homo sapiens
pH and temperature not specified in the publication
0.000063
4-cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate
Rattus norvegicus
pH and temperature not specified in the publication
0.000073
4-cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate
Homo sapiens
pH 7.4, 37°C
0.0000072
Homo sapiens
recombinant enzyme with substrate N-palmitoylethanolamine, pH not specified in the publication, 37°C
0.0000077
5-((biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide
Homo sapiens
recombinant enzyme with substrate N-(4-methyl coumarin)palmitamide, pH not specified in the publication, 37°C
0.000007
Homo sapiens
pH and temperature not specified in the publication
0.05
5-phenylpentyl [(2S,3R)-2-methyl-4-oxooxetan-3-yl]carbamate
Rattus norvegicus
pH and temperature not specified in the publication
0.000007
Homo sapiens
pH and temperature not specified in the publication
0.00005
5-phenylpentyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]carbamate
Rattus norvegicus
pH and temperature not specified in the publication
0.0017
Homo sapiens
recombinant enzyme with substrate N-(4-methyl coumarin)palmitamide, pH not specified in the publication, 37°C
0.0019
N-benzyloxycarbonyl-L-serine beta-lactone
Homo sapiens
recombinant enzyme with substrate N-palmitoylethanolamine, pH not specified in the publication, 37°C
0.0083
Rattus norvegicus
pH and temperature not specified in the publication
0.045
N-pentadecylbenzamide
Homo sapiens
pH and temperature not specified in the publication
0.098
N-pentadecylpyridine-4-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0057
Rattus norvegicus
pH and temperature not specified in the publication
additional information
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-(2-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-(2-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-(2-methylphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-(3,4-dimethylphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-(3-aminophenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-(3-chloro-4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-(4-iodophenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-(4-methoxyphenyl)hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzamide
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzoic acid
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-[3-(hydroxymethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
3-[6-[4-(methylsulfanyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication
additional information
4-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzamide
Rattus norvegicus
above 20 mM, pH and temperature not specified in the publication