3.5.1.60: N-(long-chain-acyl)ethanolamine deacylase
This is an abbreviated version!
For detailed information about N-(long-chain-acyl)ethanolamine deacylase, go to the full flat file.
Reaction
Synonyms
acylethanolamine acid amidase, amidase, acylethanolamine, hNAAA, N-acylethanolamine acid amidase, N-acylethanolamine amidohydrolase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, Nacylethanolamine acid amidase, NAE-hydrolyzing acid amidase
ECTree
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Engineering
Engineering on EC 3.5.1.60 - N-(long-chain-acyl)ethanolamine deacylase
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C116A
site-directed mutagenesis, inhibition of disulfide bridge formation
L325A
site-directed mutagenesis of isozyme A, the mutant shows reduced activity compared to wild-type
L325T
site-directed mutagenesis of isozyme A, the mutant shows reduced activity compared to wild-type
N112S
site-directed mutagenesis, the mutation abolishes an N-linked glycosylation site
N338S
site-directed mutagenesis, the mutation abolishes an N-linked glycosylation site4
T335A
site-directed mutagenesis of isozyme A, the mutant is almost inactive
T335V
site-directed mutagenesis of isozyme A, the mutant is almost inactive
additional information
selective alkylation of the enzyme's cysteine residues results in almost complete loss of activity