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3.5.1.60: N-(long-chain-acyl)ethanolamine deacylase

This is an abbreviated version!
For detailed information about N-(long-chain-acyl)ethanolamine deacylase, go to the full flat file.

Reaction

N-(long-chain-acyl)ethanolamine
+
H2O
=
a long-chain carboxylate
+
ethanolamine

Synonyms

acylethanolamine acid amidase, amidase, acylethanolamine, hNAAA, N-acylethanolamine acid amidase, N-acylethanolamine amidohydrolase, N-acylethanolamine-hydrolyzing acid amidase, N-acylethanolaminehydrolyzing acid amidase, NAAA, Nacylethanolamine acid amidase, NAE-hydrolyzing acid amidase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.60 N-(long-chain-acyl)ethanolamine deacylase

Crystallization

Crystallization on EC 3.5.1.60 - N-(long-chain-acyl)ethanolamine deacylase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified recombinant enzyme in complex with inhibitor ARN726, and in presence of Triton X-100, X-ray diffraction structure determination and analysis at 3.0. A resolution
purified recombinnat enzyme C116A mutant in complex with ARN19702 and in presence of Triton X-100, X-ray diffraction structure determination and analysis at 3.0 A resolution
purified recombinant enzyme C116A mutant in complex with inhibitors ARN726, ARN19702, and with substrate myristate, and in presence of Triton X-100, X-ray diffraction structure determination and analysis at 2.7 A resolution