3.5.1.6: beta-ureidopropionase

This is an abbreviated version!
For detailed information about beta-ureidopropionase, go to the full flat file.

Reaction

Synonyms

3-ureidopropionase, beta-Ala synthase, beta-alanine synthase, beta-UP, beta-ureidopropionase, beta-ureidopropionate decarbamylase, betaAS, betaUP, betaUPase, BUP-1, BUP1, human liver beta-ureidopropionase, N-carbamoyl-beta-Ala amidohydrolase, N-carbamoyl-beta-alanine amidohydrolase, N-carbamyl-beta-alanine decarbamylase, NCbetaA, PYD3, SkbetaAS, UPB1

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.6 beta-ureidopropionase

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Results	in table
1	Activating Compound
319	AA Sequence
3	Application
1	CAS Registry Number
16	Cloned(Commentary)
6	Crystallization (Commentary)
60	Disease/ Diagnostics
13	General Information
3	General Stability
9	IC50 Value
77	Inhibitors
23	kcat/KM [mM/s]
9	Ki Value [mM]
68	KM Value [mM]
12	Localization
18	Metals/Ions
35	Molecular Weight [Da]
73	Natural Substrates/ Products (Substrates)
144	Organism
11	Pathway
49	PDB ID
15	pH Optimum
3	pH Range
1	pH Stability
2	pI Value
44	Protein Variants
28	Purification (Commentary)
4	Reaction
1	Reaction Type
95	Reference
69	Source Tissue
27	Specific Activity [micromol/min/mg]
5	Storage Stability
234	Substrates and Products (Substrate)
27	Subunits
53	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
37	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 3.5.1.6 - beta-ureidopropionase

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-25°C 50% decrease in specific activity within a few days 4°C, 50% glycerol solution 20% decrease in activity at 1 month, 50% decrease at 2 months of storage

Rattus rattus

-

172056

-70°C, partially purified beta-UP, in presence of 10% w/v glycerol, several months, stable

Zea mays

-

657030

4°C, 50 mM Tris buffer with 10% glycerol + 10 mM 2-mercaptoethanol or 2 mM dithiothreitol enzyme loses less than 20% activity when maintained for 3 days

Rattus rattus

-

172058

4°C, buffer without stabilizing detergents and reducing thiols, 26 days, almost complete loss of activity

Rattus norvegicus

-

656700

4°C, partially purified beta-UP, in presence of Mg2+ and dithiothreitol, 7 days, about 10% loss of activity

Zea mays

-

657030