Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.5.1.5: urease

This is an abbreviated version!
For detailed information about urease, go to the full flat file.

Word Map on EC 3.5.1.5

Reaction

Urea
+
H2O
=
CO2
+ 2 NH3

Synonyms

acid urease, Arthritogenic cationic 19 kDa antigen, BPU, canatoxin, embryo-specific soybean urease, Eu1, Eu4, HPU, jack bean urease, JBU, JBURE-II, More, PMU, urea amido hydrolase, Urea amidohydrolase, urease, urease JBURE-IIb, UreC

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.5 urease

KI Value

KI Value on EC 3.5.1.5 - urease

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.017 - 0.018
(2S)-2-(dimethylamino)-3-(ethylthio)propan-1-ol
0.002 - 0.055
(2S)-2-(dimethylamino)-3-ethoxypropane-1-thiol
0.002 - 0.013
(2S)-2-(dimethylamino)-3-mercaptopropan-1-ol
0.002 - 0.019
(2S)-2-(dimethylamino)-3-methoxypropane-1-thiol
0.34
(aminomethyl)methylphosphinic acid
-
pH 7.0, 37°C
0.24 - 0.314
(aminomethyl)phosphonic acid
0.000407
(E)-1-((E)-3-phenylallylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.00017
(E)-1-(2-chlorobenzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.00091
(E)-1-(3,4,5-trimethoxybenzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.00067
(E)-1-(3-bromobenzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.000625
(E)-1-(3-chlorobenzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.000127
(E)-1-(3-methoxybenzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.00009
(E)-1-(3-nitrobenzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.000122
(E)-1-(4-(N,N-dimethylamino)benzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.00077
(E)-1-(4-bromobenzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.000398
(E)-1-(4-chlorobenzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.000807
(E)-1-(4-methoxybenzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.000497
(E)-1-(4-nitrobenzylidene)thiosemicarbazide
-
pH 8.2, 37°C
0.00043
(E)-2-((E)-but-2-enylidene)hydrazinecarbothioamide
-
pH 8.2, 37°C
0.000127
(E)-2-(2,3-dihydroxybenzylidene)hydrazinecarbothioamide
-
pH 8.2, 37°C
0.000152
(E)-2-(2-(benzyloxy)benzylidene)hydrazinecarbothioamide
-
pH 8.2, 37°C
0.000191
(E)-2-(3-(benzyloxy)-4-methoxybenzylidene)hydrazinecarbothioamide
-
pH 8.2, 37°C
0.000134
(E)-2-(4-hydroxy-3,5-dimethoxybenzylidene)hydrazinecarbothioamide
-
pH 8.2, 37°C
0.000391
(E)-2-(4-hydroxybenzylidene)hydrazinecarbothioamide
-
pH 8.2, 37°C
0.014 - 0.0175
([[(benzyloxy)carbonyl]amino]methyl)methylphosphinothioic O-acid
0.000094
1,1-dimethyl-3-[(1S)-1-naphthalen-1-ylethyl]selenourea
-
-
0.0181
1,3-bis(3-chlorophenyl)thiourea
-
pH 6.8, 30°C
0.0156
1-(3-bromophenyl)-3-phenylthiourea
-
pH 6.8, 30°C
0.0193
1-(3-chlorophenyl)-3-(2,5-dimethylphenyl)thiourea
-
pH 6.8, 30°C
0.0117
1-(3-chlorophenyl)-3-(3,4-dichlorophenyl)thiourea
-
pH 6.8, 30°C
0.0181
1-(3-chlorophenyl)-3-(4-chlorophenyl)thiourea
-
pH 6.8, 30°C
0.0168
1-(3-chlorophenyl)-3-(4-fluorophenyl)thiourea
-
pH 6.8, 30°C
0.0157
1-(3-chlorophenyl)-3-(m-tolyl)thiourea
-
pH 6.8, 30°C
0.0121
1-(3-chlorophenyl)-3-(p-tolyl)thiourea
-
pH 6.8, 30°C
0.0185
1-(5-chloro-2-methylphenyl)-3-(3-chlorophenyl)thiourea
-
pH 6.8, 30°C
0.358
1-benzyl-2-ethyl-6,6-dimethyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one
-
pH 3.85, 36°C
0.106 - 0.754
1-benzyl-2-ethyl-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one
0.000025
1-cyclohexyl-3,3-dimethyl-1-(1-methylethyl)selenourea
-
-
0.446
1-ethoxy-2-ethyl-6,6-dimethyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one
-
pH 3.85, 36°C
0.566
1-ethoxy-2-ethyl-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one
-
pH 3.85, 36°C
0.0086
1-phenyl-3-(pyridin-3-yl)thiourea
-
pH 6.8, 30°C
0.02 - 0.03
2,2'-bi-1,3,4-oxadiazole-5,5'(4H,4'H)-dithione
0.002 - 0.005
2,2'-bi-1,3,4-thiadiazole-5,5'(4H,4'H)-dithione
0.169
2-ethyl-1-(2-phenylethyl)-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one
-
pH 3.85, 36°C
0.0293
2-ethyl-1-(4-methoxycyclohexyl)-6,6-dimethyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one
-
pH 3.85, 36°C
0.0495
2-ethyl-1-(4-methoxyphenyl)-6-(2,4,6-trimethylphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one
-
pH 3.85, 36°C
0.0817
2-ethyl-6-[2-(ethylsulfanyl)propyl]-1-(4-methoxyphenyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one
-
pH 3.85, 36°C
0.0059
2-[(1E)-N-(allyloxy)butanimidoyl]-5,5-dimethylcyclohexane-1,3-dione
-
-
0.0086
2-[(1E)-N-ethoxybutanimidoyl]-5,5-dimethylcyclohexane-1,3-dione
-
-
0.000000003
2-[4-(2-methylpropyl)phenyl]-N-[(2,4,6-trimethylphenyl)carbamothioyl]propanamide
pH 8.2, 37°C, mixed-type inhibition
0.0000000025
2-[4-(2-methylpropyl)phenyl]-N-[(3-nitrophenyl)carbamothioyl]propanamide
pH 8.2, 37°C, mixed-type inhibition
0.000135
3-(4-bromobenzyl)-1,1-dimethylselenourea
-
-
0.000255
3-(4-bromophenyl)-1,1-dimethylthiourea
-
-
0.000124
3-dodecyl-1,1-dimethylthiourea
-
-
0.04 - 0.29
4-(4-benzoyl-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)phenyl benzoate
0.29 - 0.31
4-amino-5-(4-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
0.2 - 0.24
4-amino-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione
0.22 - 0.3
4-bromophenylboronic acid
0.019 - 0.0215
4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)-3-phenylprop-2-en-1-yl]-2H-chromen-2-one
0.0483 - 0.0659
4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)but-2-en-1-yl]-2H-chromen-2-one
0.0595 - 0.068
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-indol-3-yl)methyl]-2H-chromen-2-one
0.0533 - 0.0681
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-pyrrol-3-yl)methyl]-2H-chromen-2-one
0.0155 - 0.0193
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(3-methoxyphenyl)methyl]-2H-chromen-2-one
0.0513 - 0.071
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(pyridin-4-yl)methyl]-2H-chromen-2-one
0.0133 - 0.015
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)methyl]-2H-chromen-2-one
0.053 - 0.0594
4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)ethyl]-2H-chromen-2-one
0.0275 - 0.075
4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)pentyl]-2H-chromen-2-one
0.13
5-(1-naphthyl)-1,3,4-oxadiazole-2(3H)-thione
0.15 - 0.16
5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
0.05
5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
0.002
5-(4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione
0.06 - 0.19
5-(4-propoxyphenyl)-3-propyl-1,3,4-thiadiazole-2(3H)-thione
0.04 - 0.11
5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione
0.06 - 0.12
5-benzhydryl-1,3,4-thiadiazole-2(3H)-thione
0.14 - 0.17
5-benzyl-1,3,4-oxadiazole-2(3H)-thione
0.09 - 0.1
5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione
0.16 - 0.19
5-phenyl-1,3,4-oxadiazole-2(3H)-thione
0.02 - 0.1
5-phenyl-1,3,4-thiadiazole-2(3H)-thione
0.09
5-pyridin-4-yl-1,3,4-oxadiazole-2(3H)-thione
0.11
5-pyridin-4-yl-1,3,4-thiadiazole-2(3H)-thione
0.005
5-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione
0.005 - 0.008
5-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-1,3,4-thiadiazole-2(3H)-thione
0.006 - 0.01
5-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-1,3,4-oxadiazole-2(3H)-thione
0.09 - 0.16
5-[3-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione
0.69 - 0.85
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazole-2(3H)-thione
0.23
5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]oxadiazole-2-thione
0.15 - 0.25
5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3H-[1,3,4]thiadiazole-2-thione
0.77
Acetohydroxamic acid
competitive
0.34 - 0.425
aminomethyl(P-methyl)phosphinic acid
0.18 - 0.35
Boric acid
1.5 - 1.8
butylboronic acid
1.04
Hydroxyurea
competitive
0.0054
methyl (7E)-7-[4,4-dimethyl-3-(3-methylisoxazol-5-yl)-2,6-dioxocyclohexyl]-7-(ethoxyimino)heptanoate
-
-
0.0049
methyl 5-[(1E)-N-(allyloxy)butanimidoyl]-2,2-dimethyl-4,6-dioxocyclohexanecarboxylate
-
-
0.0027
methyl 5-[(1E)-N-ethoxybutanimidoyl]-2,2-dimethyl-4,6-dioxocyclohexanecarboxylate
-
pH 4.95, 36°C
0.0041
methyl 5-[(1E)-N-ethoxyethanimidoyl]-2,2-dimethyl-4,6-dioxocyclohexanecarboxylate
-
-
0.018 - 0.224
methyl[(methylamino)methyl]phosphinic acid
0.00017 - 0.00045
N-(N'-benzyloxycarbonylglycyl)aminomethyl(P-methyl)phosphinothioic acid
0.043 - 0.065
N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid
0.002 - 0.009
N-dimethyl-L-cysteine
0.006 - 0.008
N-dimethyl-S-methyl-L-cysteine
7 - 7.5
N-ethylmaleimide
0.021 - 0.03
N-glycyl-aminomethyl(P-methyl)phosphinic acid
0.0000000012
N-[(2,3-dichlorophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
pH 8.2, 37°C, competitive inhibition, irreversible
0.176 - 0.215
N-[[hydroxy(methyl)phosphoryl]methyl]-L-phenylalaninamide
0.037 - 0.041
N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
0.12 - 0.208
N-[[hydroxy(methyl)phosphoryl]methyl]-L-valinamide
0.135 - 0.178
N2-[(benzyloxy)carbonyl]-N-[[hydroxy(methyl)phosphoryl]methyl]glycinamide
1.3
NaF
-
pH 7.0, 37°C
0.025 - 0.0326
O-benzyl-N-[[hydroxy(methyl)phosphoryl]methyl]-L-serinamide
2 - 2.5
phenylboronic acid
0.011 - 0.014
S-ethyl-L-cysteine
0.19
sulfite
pH 7.0, 25°C
0.0024
tetrachloro-o-benzoquinone
-
-
0.00045
tetrachloro-p-benzoquinone
-
-
0.0196 - 26.12
Thiourea
0.095 - 0.295
[(acetylamino)methyl]methylphosphinic acid
0.148
[(acetylamino)methyl]phosphonic acid
-
pH 7.0, 37°C
0.072 - 0.571
[(benzylamino)methyl]methylphosphinic acid
0.00062 - 0.0037
[(dimethylamino)methyl]methylphosphinic acid
0.013 - 0.021
[(dimethylamino)methyl]phosphonic acid
0.07 - 0.204
[(methylamino)methyl]phosphonic acid
0.115
[[benzyl(methyl)amino]methyl]phosphonic acid
-
pH 7.0, 37°C
additional information
additional information
-