3.5.1.36: N-methyl-2-oxoglutaramate hydrolase

This is an abbreviated version!
For detailed information about N-methyl-2-oxoglutaramate hydrolase, go to the full flat file.

Reaction

N-Methyl-2-oxoglutaramate
+
H2O
=
2-oxoglutarate
+
methylamine

Synonyms

5-hydroxy-N-methylpyroglutamate synthase, 5-hydroxy-N-methylpyroglutamate synthetase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.36 N-methyl-2-oxoglutaramate hydrolase

Inhibitors

Inhibitors on EC 3.5.1.36 - N-methyl-2-oxoglutaramate hydrolase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-hydroxy-4-methoxy-benzophenone
-
with 1 micromol 2-hydroxy-4-methoxy-benzophenone the activity is 0% after 10 min
aliphatic alcohols
-
with respect to amines in acyl transfer reactions
butanol
-
competitive inhibitors with respect to methylamine and ethanolamine
DTNB
-
with 20 micromol DTNB the activity is 5% after 10 min
iodoacetamide
-
with 20 micromol iodoacetamide the activity is 20% after 10 min
iodoacetate
-
with 20 micromol iodoacetate the activity is 33% after 10 min
N-Methylmaleimide
-
with 20 micromol N-methylmaleimide the activity is 2% after 10 min
NEM
-
with 20 micromol NEM the activity is 0% after 10 min
oxalacetate
-
a competitive inhibitor
p-hydroxymercurisulfonate
-
with 1 micromol p-hydroxymercurisulfonate the activity is 0% after 10 min
Pentanol
-
competitive to ethanolamine
Propanol
-
competitive to ethanoamine
Tris-HCl
-
-
additional information
-
not inhibited by triethanolamine, 2-methylimidazole, diphosphate and Tricine buffer
-