3.5.1.36: N-methyl-2-oxoglutaramate hydrolase

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For detailed information about N-methyl-2-oxoglutaramate hydrolase, go to the full flat file.

Reaction

Synonyms

5-hydroxy-N-methylpyroglutamate synthase, 5-hydroxy-N-methylpyroglutamate synthetase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.36 N-methyl-2-oxoglutaramate hydrolase

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Results	in table
5	Activating Compound
1	CAS Registry Number
14	Inhibitors
6	KM Value [mM]
1	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
36	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
3	Reaction Type
8	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
10	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.5.1.36 - N-methyl-2-oxoglutaramate hydrolase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2-hydroxy-4-methoxy-benzophenone

Pseudomonas sp.

-

with 1 micromol 2-hydroxy-4-methoxy-benzophenone the activity is 0% after 10 min

209087

aliphatic alcohols

Pseudomonas sp.

-

with respect to amines in acyl transfer reactions

209085

butanol

Pseudomonas sp.

-

competitive inhibitors with respect to methylamine and ethanolamine

209085

DTNB

Pseudomonas sp.

-

with 20 micromol DTNB the activity is 5% after 10 min

209087

iodoacetamide

Pseudomonas sp.

-

with 20 micromol iodoacetamide the activity is 20% after 10 min

209087

iodoacetate

Pseudomonas sp.

-

with 20 micromol iodoacetate the activity is 33% after 10 min

209087

N-Methylmaleimide

Pseudomonas sp.

-

with 20 micromol N-methylmaleimide the activity is 2% after 10 min

209087

NEM

Pseudomonas sp.

-

with 20 micromol NEM the activity is 0% after 10 min

209087

oxalacetate

Pseudomonas sp.

-

a competitive inhibitor

209087

p-hydroxymercurisulfonate

Pseudomonas sp.

-

with 1 micromol p-hydroxymercurisulfonate the activity is 0% after 10 min

209087

Pentanol

Pseudomonas sp.

-

competitive to ethanolamine

209085

Propanol

Pseudomonas sp.

-

competitive to ethanoamine

209085

Tris-HCl

Pseudomonas sp.

-

-

209088

additional information

Pseudomonas sp.

-

not inhibited by triethanolamine, 2-methylimidazole, diphosphate and Tricine buffer

209088

-