3.5.1.36: N-methyl-2-oxoglutaramate hydrolase

This is an abbreviated version!
For detailed information about N-methyl-2-oxoglutaramate hydrolase, go to the full flat file.

Reaction

N-Methyl-2-oxoglutaramate
+
H2O
=
2-oxoglutarate
+
methylamine

Synonyms

5-hydroxy-N-methylpyroglutamate synthase, 5-hydroxy-N-methylpyroglutamate synthetase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.36 N-methyl-2-oxoglutaramate hydrolase

Activating Compound

Activating Compound on EC 3.5.1.36 - N-methyl-2-oxoglutaramate hydrolase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetone
-
noncompetitive activator with respect to ethanolamine
aliphatic alcohols
-
7fold increase of hydrolysis of alpha-ketoglutaramate and ethyl alpha-ketoglutarate
Dimethyl formamide
-
noncompetitive activator with respect to ethanolamine
dioxane
-
noncompetitive activator, effect on the reaction of methylamine with ethyl alpha-ketoglutarate
organic solvents
-
increase both hydrolysis and transfer reactions involving amines, accelerated up to 7fold
-